2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE
- Product Name
- 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE
- CAS No.
- 72836-33-0
- Chemical Name
- 2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE
- Synonyms
- TIMTEC-BB SBB005594;2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE;5-((4-CHLOROBENZYL)THIO)-1,3,4-THIADIAZOL-2-AMINE;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-AMINE;[5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-yl]amine;5-[(4-CHLOROBENZYL)SULFANYL]-1,3,4-THIADIAZOL-2-YLAMINE;5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine;1,3,4-Thiadiazol-2-amine, 5-[[(4-chlorophenyl)methyl]thio]-;5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
- CBNumber
- CB7208144
- Molecular Formula
- C9H8ClN3S2
- Formula Weight
- 257.76
- MOL File
- Mol file
2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Property
- Melting point:
- 168-169 °C(Solv: ethyl acetate (141-78-6))
- Boiling point:
- 443.8±47.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- pka
- 2.41±0.10(Predicted)
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- 5.30353
- Product name
- Regacin - CAS 72836-33-0 - Calbiochem
- Packaging
- 25mg
- Price
- $243
- Updated
- 2023/01/07
- Product number
- C364923
- Product name
- 5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-ylamine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 1031CC
- Product name
- 2-Amino-5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazole
- Packaging
- 250mg
- Price
- $166
- Updated
- 2021/12/16
- Product number
- 1031CC
- Product name
- 2-Amino-5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazole
- Packaging
- 1g
- Price
- $271
- Updated
- 2021/12/16
- Product number
- 7H66-5-17
- Product name
- 2-Amino-5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazole
- Packaging
- 1g
- Price
- $448
- Updated
- 2021/12/16
2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Chemical Properties,Usage,Production
Definition
ChEBI: 5-[(4-chlorophenyl)methylthio]-1,3,4-thiadiazol-2-amine is an aryl sulfide.
General Description
An orally bioavailable, non-toxic, thio-thiadiazolamine compound that specifically inhibits the DNA-binding capacity of virulence regulator, RegA (IC50 = 1.7 μM in E. coli strain MC4100 (kfc-lacZ, pACYC184-regA), by interacting with amino acid residues within a conserved region of the DNA-binding domain, but without affecting RegA dimerization. Interacts with the double helix-turn-helix (HTH) domain that results in a loss of binding affinity of RegA for its DNA targets. This interaction appears to involve W188 and R223 residues that are conserved in several RegA homologs including ToxT, AggR, RegR, and Rns. Shown to be highly effective in reducing Citrobacter rodentium colonization when administered perorally to mice (~50 mg/kg) either 15 minutes before or 12 hours after bacterial inoculation. Reduces the ability of Rns and RegR to activate the transcription of their target promoters, but does not affect the activity of AggR and ToxT.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
2-AMINO-5-(4-CHLOROBENZYLTHIO)1,3,4-THIADIAZOLE Suppliers
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