ChemicalBook > CAS DataBase List > Z-Lys(Z)-OH

Z-Lys(Z)-OH

Product Name
Z-Lys(Z)-OH
CAS No.
405-39-0
Chemical Name
Z-Lys(Z)-OH
Synonyms
Z-Lys;CBZ-LYS(CBZ)-OH;Cbz-Lys(Z)-OH;Z-LYS(Z);NSC 88474;Z-LYS(Z)-OH;Z-Lys(Z)-0H;Z-L-Lys(Z)-OH;Z-LYSINE(Z)-OH;DI-N-CBZ-L-LYSINE
CBNumber
CB7208816
Molecular Formula
C22H26N2O6
Formula Weight
414.45
MOL File
405-39-0.mol
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Z-Lys(Z)-OH Property

Melting point:
76-78°C
Boiling point:
659.0±55.0 °C(Predicted)
Density 
1.238±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
3.97±0.21(Predicted)
color 
White to Off-White
BRN 
1897206
InChIKey
BLZXFNUZFTZCFD-IBGZPJMESA-N
SMILES
C(O)(=O)[C@H](CCCCNC(OCC1=CC=CC=C1)=O)NC(OCC1=CC=CC=C1)=O
CAS DataBase Reference
405-39-0(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
96835
Product name
Z-Lys(Z)-OH
Purity
≥98.0% (TLC)
Packaging
5g
Price
$63.3
Updated
2023/06/20
TCI Chemical
Product number
B6554
Product name
Z-Lys(z)-OH
Packaging
25G
Price
$99
Updated
2025/07/31
TRC
Product number
B410905
Product name
N2,N6-Bis(benzyloxycarbonyl)-L-lysine
Packaging
10g
Price
$60
Updated
2021/12/16
TRC
Product number
B410905
Product name
N2,N6-Bis(benzyloxycarbonyl)-L-lysine
Packaging
25g
Price
$110
Updated
2021/12/16
TRC
Product number
B410905
Product name
N2,N6-Bis(benzyloxycarbonyl)-L-lysine
Packaging
50g
Price
$145
Updated
2021/12/16
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Z-Lys(Z)-OH Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Protected L-lysine

Definition

Z-Lys(Z)-OH is a lysine derivative.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

A 250 mL three-necked flask was loaded consecutively with water (20 mL), 1,4-dioxane (20 mL), and L-lysine (2.1 g, 14.4 mmol). The mixture was stirred until complete dissolution. The pH was adjusted to about 10.5 by the addition of 30% NaOH. Benzyl chloroformate (5.2 g, 30.6 mmol) was added while maintaining the pH at about 1011 by adding at the same time 30% NaOH. At the end of the addition, the reaction was stirred at 20° C. for about 1 hour. The pH was adjusted to 5 with 37% HCl. Ethyl acetate (30 mL) was added and the pH was adjusted to 1 with 37% HCl. The mixture was stirred at room temperature for about 30 minutes, the organic layer was separated and the aqueous layer was extracted with ethyl acetate (20 mL). The combined organic layer was washed with brine (30 mL) and dried over Na2SO4. Then, the solvent was evaporated to yield Z-Lys(Z)-OH as a yellowish oil (6.0 g, 99%).

References

[1] Patent: US2006/94673, 2006, A1. Location in patent: Page/Page column 4
[2] Patent: CN106565771, 2017, A. Location in patent: Paragraph 0037; 0038; 0039
[3] Patent: CN106565772, 2017, A. Location in patent: Paragraph 0038
[4] Helvetica Chimica Acta, 1958, vol. 41, p. 1867,1876
[5] Journal of Biological Chemistry, 1935, vol. 111, p. 245,251

Z-Lys(Z)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-Lys(Z)-OH Suppliers

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View Lastest Price from Z-Lys(Z)-OH manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
N,N'-Dibenzyloxycarbonyl-L-lysine 405-39-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-10-23
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Cbz-L-Lys(Cbz)-OH 405-39-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-27
Honest Joy Holdings Limited
Product
Z-Lys(Z)-OH 405-39-0
Price
US $0.00/KG
Min. Order
1KG
Purity
97.1%
Supply Ability
100 tons
Release date
2022-02-21

405-39-0, Z-Lys(Z)-OH Related Search:

Z-LYS(Z)-ONP Z-LYS(Z)-OSU Z-LYS(Z)-OSU Z-LEU-OH DCHA Z-LYS(BOC)-OH DCHA Z-LEU-OSU Z-LYS(BOC)-OH Z-LYS(ALOC)-OH DCHA Z-LYS-OME HCL (2S)-2-{[(benzyloxy)carbonyl]amino}-6-formamidohexanoic acid Z-LYS(Z)-SER-OH Z-LYS-NH2 . HCL N-alpha-Cbz-L-lysine NEPSILON-FMOC-NALPHA-CBZ-L-LYSINE, 98 N-cyclohexylcyclohexanamine Z-LYS-OBZL BENZENESULFONATE Z-LYS(AC)-NH2 Z-LYS-ONP HCL

  • DI-N-CBZ-L-LYSINE
  • DICARBOBENZOXY-L-LYSINE
  • Z-LYSINE(Z)-OH
  • Z-LYS(Z)-OH
  • N-ALPHA,EPSILON-BIS-Z-L-LYSINE
  • N-ALPHA,N-EPSILON-DI-Z-L-LYSINE
  • N-ALPHA, N-EPSILON-DIBENZYLOXYCARBONYL-L-LYSINE
  • N-ALPHA-N-EPSILON-DICARBOBENZOXY-L-LYSINE
  • N-ALPHA-N-EPSILON-DI-CBZ-L-LYSINE
  • N,N'-DI-CBZ-L-LYSINE
  • Nα,Nε-Di-Z-L-lysine
  • di-N-CBZ-L-Lysine di-N-Carbobenzyloxy-L-lysine
  • Cbz-L-Lys(Cbz)-OH
  • Nα,ε-Bis-Z-L-lysine≥ 99% (HPLC)
  • (2S)-2,6-bis(phenylmethoxycarbonylamino)hexanoic acid
  • N,N-di-cbz-L-lysine free acid
  • N2,N6-dibenzyloxycarbonyl-L-lysine
  • Cbz-Lys(Z)-OH
  • CBZ-LYS(CBZ)-OH
  • NA,NE-DIBENZYLOXYCARBONYL-L-LYSINE
  • Z-LYS(Z)
  • L-Lysine, N2,N6-bis[(phenylmethoxy)carbonyl]-
  • N1,N6-DI-CBZ-L-LYSINE
  • N,N'-di-carbobenzyloxy-L-lysine
  • N,Nμ-Di-Cbz-L-lysine, Nα,Nε-Di-Z-L-lysine
  • N2,N6-Bis(benzyloxycarbonyl)-L-lysine
  • N2,N6-Bis(benzyloxycarbonyl)lysine
  • N2,N6-Bis[(benzyloxy)carbonyl]-L-lysine
  • Nα,Nε-Bis(benzyloxycarbonyl)-L-lysine
  • N,N'-Dibenzyloxycarbonyl-L-lysine
  • N-alpha-N-epsilon-Bis-benzyloxycarbonyl-L-lysine
  • Z-L-Lys(Z)-OH
  • N-beta,epsilon-Bis-Z-L-lysine
  • N,N'-(Dicarobenzyloxy)-L-lysine
  • N2,N6-Bis[(phenylMethoxy)carbonyl]-L-lysine
  • N2,N6-Dicarbobenzoxy-L-lysine
  • NSC 88474
  • N2,N6-Bis-Cbz-L-lysine
  • ZzLys[Z-Lys(Z)-OH]
  • (S)-2,6-Bis(((benzyloxy)carbonyl)aMino)hexanoic acid
  • Z-Lys(Z)-OH, 98%+
  • Z-Lys(Z)-OH >=98.0% (TLC)
  • (2S)-2,6-di{[(benzyloxy)carbonyl]amino}hexanoic acid
  • (2S)-2,6-bis(phenylmethoxycarbonylamino)hexanoicaci
  • Z-LYS(Z)-OH USP/EP/BP
  • Nα,ε-Bis-Z-L-lysine
  • TIANFUCHEM--405-39-0--High purity Z-LYS(Z)-OH factory price
  • N2,N6-Dibenzyloxycarbonyl-L-lysin
  • Z-Lys
  • N,N'-Bis(benzyloxycarbonyl)-L-lysine
  • N,N'-DICARBOBENZYLOXY-L-LYSINE
  • Nα,Nω-Bis(benzyloxycarbonyl)-L-lysine
  • Z-Lys(Z)-0H
  • 405-39-0
  • C6H5CH2O2CNHCH24CHNHCO2CH2C6H5CO2H
  • CARBOXYLIC ACID
  • Peptide Synthesis
  • Specialty Synthesis