1-methylquinazoline-2,4(1H,3H)-dione

Product Name: 1-methylquinazoline-2,4(1H,3H)-dione
CAS No.: 604-50-2
Chemical Name: 1-methylquinazoline-2,4(1H,3H)-dione
Synonyms: NSC401254;NSC 401254;Glycosmicine;1-methylquinazoline-2,4-dione;1-methylquinazoline-2,4-quinone;1-methylquinazoline-2,4(1H,3H)-dione;1-Methyl-2,4(1H,3H)-quinazolinedione;2,4(1H,3H)-QUINAZOLINEDIONE, 1-METHYL-;Methyl-1 (1H,3H)quinazolinedione-2,4 [French];1-Methyl-1,2,3,4-tetrahydroquinazoline-2,4-dione
CBNumber: CB72106116
Molecular Formula: C9H8N2O2
Formula Weight: 176.17
MOL File: 604-50-2.mol

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1-methylquinazoline-2,4(1H,3H)-dione Property

storage temp.: Inert atmosphere,Room Temperature
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 6531AE
Product name: 1-Methylquinazoline-2,4(1H,3H)-dione
Packaging: 1g
Price: $189
Updated: 2021/12/16

AK Scientific

Product number: 6531AE
Product name: 1-Methylquinazoline-2,4(1H,3H)-dione
Packaging: 5g
Price: $604
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0126675
Product name: 1-METHYL-2,4(1H,3H)-QUINAZOLINEDIONE
Purity: 95.00%
Packaging: 1G
Price: $818.61
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0126675
Product name: 1-METHYL-2,4(1H,3H)-QUINAZOLINEDIONE
Purity: 95.00%
Packaging: 5G
Price: $1491.68
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0126675
Product name: 1-METHYL-2,4(1H,3H)-QUINAZOLINEDIONE
Purity: 95.00%
Packaging: 10G
Price: $2279.97
Updated: 2021/12/16

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1-methylquinazoline-2,4(1H,3H)-dione Chemical Properties,Usage,Production

Synthesis

119-68-6

917-61-3

604-50-2

An aqueous solution (25 mL) of sodium cyanate (28 mmol) was added dropwise to an aqueous solution (50 mL) of N-methyl-phthalaminobenzoic acid (20 mmol) and acetic acid (0.2 mL) under stirring conditions. When the temperature of the reaction mixture rose to 40 °C, sodium hydroxide was added in batches until the reaction temperature reached 75 °C. The reaction temperature was maintained at this temperature with continuous stirring for 4 hours. This temperature was maintained and the reaction was stirred continuously for 4 hours without cooling. Upon completion of the reaction, the precipitated crystals were collected by filtration and dissolved in boiling water (50 mL). Subsequently, the above solution was acidified with 50% sulfuric acid solution to pH 1-2. The precipitated crystals were filtered, washed with water and finally recrystallized from 50% acetic acid solution to afford the target product 1-methyl-2,4(1H,3H)-quinazolinedione (2.92 g, 84% yield); the melting point was 278 °C. The reaction was carried out at a temperature of 75 °C for 4 hours.

References

[1] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 12, p. 1508 - 1514
[2] Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2013, vol. 110, p. 324 - 332
[3] Patent: WO2016/92326, 2016, A1. Location in patent: Page/Page column 97; 113
[4] Patent: EP3299371, 2018, A1. Location in patent: Paragraph 0525; 0526
[5] Letters in Drug Design and Discovery, 2014, vol. 11, # 6, p. 712 - 720

1-methylquinazoline-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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1-methylquinazoline-2,4(1H,3H)-dione Suppliers

China 26 India 1 United States 2 Global 29

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View Lastest Price from 1-methylquinazoline-2,4(1H,3H)-dione manufacturers

Career Henan Chemical Co

Product: 2,4(1H,3H)-Quinazolinedione,1-methyl- 604-50-2
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

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604-50-2