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CVT-6883

Product Name
CVT-6883
CAS No.
752222-83-6
Chemical Name
CVT-6883
Synonyms
GS-6201;CVT-6883;GS6201 CVT6883;GS-6201, 10 mM in DMSO;GS 6201; GS6201; GS6201; CVT6883; CVT-6883;3-Ethyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,8H)-dione;3-Ethyl-1-propyl-8-[1-(3-trifluoromethyl-benzyl)-1H-pyrazol-4-yl]-3,7-dihydro-purine-2,6-dione;3-Ethyl-1-Propyl-8-(1-(3-(Trifluoromethyl)Benzyl)-1H-Pyrazol-4-Yl)-3,7-Dihydro-1H-Purine-2,6-Dione;3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6;3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoroMethyl)phenyl]Methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione
CBNumber
CB72128671
Molecular Formula
C21H21F3N6O2
Formula Weight
446.43
MOL File
752222-83-6.mol
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CVT-6883 Property

Boiling point:
639.6±65.0 °C(Predicted)
Density 
1.44
storage temp. 
Store at -20°C
solubility 
DMSO: soluble
form 
A solid
pka
7.69±0.70(Predicted)
color 
White to light brown
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3640
Product name
GS-6201
Purity
≥98% (HPLC)
Packaging
5mg
Price
$77.42
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3640
Product name
GS-6201
Purity
≥98% (HPLC)
Packaging
25mg
Price
$329
Updated
2025/07/31
Tocris
Product number
4727
Product name
GS6201
Purity
≥99%(HPLC)
Packaging
10
Price
$216
Updated
2021/12/16
Tocris
Product number
4727
Product name
GS6201
Purity
≥99%(HPLC)
Packaging
50
Price
$865
Updated
2021/12/16
Usbiological
Product number
255403
Product name
GS 6201
Packaging
10mg
Price
$466
Updated
2021/12/16
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CVT-6883 Chemical Properties,Usage,Production

Uses

3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione, is a novel selective, high-affinity A2B adenosine receptor (AR) antagonist, used for the treatment of inflammatory and angiogenic diseases.

Biological Activity

GS-6201 (CVT-6883) is a potent and selective A2B adenosine receptor (A2BAdoR) antagonist. GS-6201 reduces caspase-1 activity in the heart and leads to a more favorable cardiac remodeling in a mouse model of non-reperfused myocardial infarction. Also GS-6201 attenuated vascular remodeling and hypertension in mouse model.

in vivo

GS-6201 (CVT-6883) (4 mg/kg; i.p.; every 12 h for 14 days) significantly reduces IL-6, TNF-α, E-selectin, ICAM-1, and VCAM plasma levels[2].
GS-6201 (4 mg/kg; i.p.; every 12 h for 14 days) leads to a significant attenuation of left and right ventricular enlargement and dysfunction at 7 days, which was maintained at 14 days and also at 28 days[2].
GS-6201 (2 mg/kg; p.o.) treatment shows the Cmax, dAUC and t1/2 are 1110 ng/mL, 6500 ng h/mL, and 4.25 hours, respectively[1].

Animal Model:Adult out-bred male CD1 mice (8-12 weeks of age, AMI model)[2]
Dosage:4 mg/kg
Administration:i.p.; every 12 h for 14 days
Result:Significantly reduced IL-6, TNF-α, E-selectin, ICAM-1, and VCAM plasma levels.
Animal Model:Sprague-Dawley rats[1]
Dosage:2 mg/kg
Administration:p.o. (Pharmacokinetic Analysis)
Result:The Cmax, dAUC and t1/2 were 1110 ng/mL, 6500 ng h/mL, and 4.25 hours, respectively.

storage

Store at -20°C

CVT-6883 Preparation Products And Raw materials

Raw materials

Preparation Products

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CVT-6883 Suppliers

China 51 United Kingdom 1 United States 9 Global 61
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
DKMbiochem.Co. Ltd
Tel
15901859516
Fax
15901859516
Email
sales@DKMbiochem.com
Country
China
ProdList
344
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58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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60
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
983
Advantage
55
Shanghai Boyners Pharm-Tech Co., Ltd.
Tel
13817873692
Fax
021-31329586
Email
mkt@boynerspharm.com
Country
China
ProdList
1707
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
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View Lastest Price from CVT-6883 manufacturers

Career Henan Chemical Co
Product
CVT 6883 752222-83-6
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10

752222-83-6, CVT-6883Related Search:

Benzyl acetate Benzyltriethylammonium chloride Benzyl butyrate Benzyltrimethylammonium chloride Benzyl alcohol Benzyl benzoate Propyl butyrate N,N-Diisopropylethylamine Benzyl bromide Purine Propyl gallate DIBENZYLTOLUENE Benzyl chloride N,N-Dimethylbenzylamine Benzyl Phenylacetone Trifluoromethyl CVT-6883

  • CVT-6883
  • 3-Ethyl-1-propyl-8-[1-(3-trifluoromethyl-benzyl)-1H-pyrazol-4-yl]-3,7-dihydro-purine-2,6-dione
  • GS6201 CVT6883
  • GS-6201
  • 3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoroMethyl)phenyl]Methyl]-1H-pyrazol-4-yl]-1H-purine-2,6-dione
  • 3-Ethyl-1-propyl-8-(1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-1H-purine-2,6(3H,8H)-dione
  • GS 6201; GS6201; GS6201; CVT6883; CVT-6883
  • 1H-Purine-2,6-dione, 3-ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-
  • CVT 6883,Inhibitor,remodeling,cardiac,CVT6883,caspase-1,GS6201,reactivity,GS 6201,airway,affinity,infarction,P1 receptor,inhibit,GS-6201,acute,Adenosine Receptor,selectivity,myocardial
  • 3-Ethyl-1-Propyl-8-(1-(3-(Trifluoromethyl)Benzyl)-1H-Pyrazol-4-Yl)-3,7-Dihydro-1H-Purine-2,6-Dione
  • GS-6201, 10 mM in DMSO
  • 3-Ethyl-3,9-dihydro-1-propyl-8-[1-[[3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-1H-purine-2,6
  • 752222-83-6
  • C21H21F3N6O2