meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%
- Product Name
- meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%
- CAS No.
- 86212-34-2
- Chemical Name
- meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%
- Synonyms
- 1,2-Bis(4-chlorophenyl)ethylenediamine;1,2-BIS(4-CHLOROPHENYL)-1,2-ETHANEDIAMINE;1,?2-?Ethanediamine, 1,?2-?bis(4-?chlorophenyl)?-;meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98%
- CBNumber
- CB72129401
- Molecular Formula
- C14H14Cl2N2
- Formula Weight
- 281.18
- MOL File
- 86212-34-2.mol
meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% Property
- Melting point:
- 137-138 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 418.6±40.0 °C(Predicted)
- Density
- 1.303±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.32±0.10(Predicted)
Safety
- HS Code
- 2921599090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L300926
- Product name
- 1,2-BIS(4-CHLOROPHENYL)-1,2-ETHANEDIAMINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- L300926
- Product name
- 1,2-BIS(4-CHLOROPHENYL)-1,2-ETHANEDIAMINE
- Purity
- Aldrich
- Packaging
- 5mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- B405328
- Product name
- 1,2-bis(4-Chlorophenyl)ethane-1,2-diamine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B405328
- Product name
- 1,2-bis(4-Chlorophenyl)ethane-1,2-diamine
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC33602
- Product name
- 1,2-bis(4-Chlorophenyl)ethane-1,2-diamine
- Packaging
- 10mg
- Price
- $210
- Updated
- 2021/12/16
meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% Chemical Properties,Usage,Production
Synthesis
104-88-1
86212-34-2
GENERAL STEPS: This is a modified protocol of the previous study method. A suspension of pre-distilled p-chlorobenzaldehyde (50 mmol) with ammonium acetate (150 mmol) was heated and stirred at 120°C for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and the gelatinous residue was washed with hexane. The crude product was alkalized with 4 M NaOH aqueous solution to pH >10 and subsequently extracted with ether (4 x 20 mL). The organic phases were combined, dried and filtered, and the solvent was evaporated under reduced pressure. The resulting intermediate was suspended directly in 50% aqueous H2SO4 (40 mL) without further purification and the mixture was heated at 170 °C overnight. The reaction solution was cooled in an ice bath and water (20 mL) was added slowly. After returning the solution to room temperature, it was extracted with ether (4 x 60 mL). The aqueous phase was neutralized with concentrated ammonia and extracted again with ether (4 x 60 mL). The organic phases were combined, dried and filtered, and the solvents were evaporated under reduced pressure to give endo-1,2-bis(4-chlorophenyl)ethane-1,2-diamine as a white, yellow or brown solid (isolated yield 40-98%). Endo-1,2-bis(4-chlorophenyl)ethane-1,2-diamine (2c) was a yellow solid (3.43 g, 98% isolated yield). Thin-layer chromatography Rf value (60% methanol/ethyl acetate): 0.47; Melting point: 126-128 °C; IR spectrum (KBr, cm?1): 3380, 2950, 1600, 1202, 980, 820; 1H NMR (300.13 MHz, CDCl3, Me4Si): δ 1.53 (br s, 4H), 4.00 (s, 2H), 7.27-7.34 (m, 8H); 13C NMR (75.5 MHz, CDCl3, Me4Si): δ 62.0 (2CH), 128.5 (4CH), 128.9 (4CH), 133.4 (2C), 140.9 (2C); Mass Spectra (ESI+, m/z): 281.0 [(M+H)+, 100%]; high-resolution mass spectrum (ESI+, m/z) C14H15Cl2N2 (M+H)+ Calculated: 281.0607, measured: 281.0592 (35Cl,35Cl), 283.0563 (35Cl,37Cl).
References
[1] Tetrahedron Asymmetry, 2014, vol. 25, # 4, p. 381 - 386
[2] Journal of the Chemical Society, 1957, p. 4407
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 18, p. 5454 - 5461
[4] Patent: US9988368, 2018, B1
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 16, p. 7245 - 7260
meso-1,2-Bis(4-chlorophenyl)ethylenediamine, min. 98% Preparation Products And Raw materials
Raw materials
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