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4-Cyanotetrahydro-4H-pyran

Product Name
4-Cyanotetrahydro-4H-pyran
CAS No.
4295-99-2
Chemical Name
4-Cyanotetrahydro-4H-pyran
Synonyms
oxane-4-carbonitrile;4-cyanotetrahydropiran;4-Cyanotetrahydropyran;4-CYANOTETRAHYDRO-4H-PYRAN;Tetrahydro-pyran-4-carbonitrile;2H-Pyran-4-carbonitrile, tetrahydro-;4-Cyanotetrahydro-4H-pyran manufacturer;4-Cyanotetrahydro-4H-pyran ISO 9001：2015 REACH;tetrahydro-2H-pyran-4-carbonitrile(SALTDATA: FREE)
CBNumber
CB72130027
Molecular Formula
C6H9NO
Formula Weight
111.14
MOL File
4295-99-2.mol
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4-Cyanotetrahydro-4H-pyran Property

Boiling point:
82-83 °C(Press: 10 Torr)
Density 
1.0343 g/cm3
refractive index 
1.4521
storage temp. 
2-8°C
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C6H9NO/c7-5-6-1-3-8-4-2-6/h6H,1-4H2
InChIKey
RLZJFTOYCVIYLE-UHFFFAOYSA-N
SMILES
C1OCCC(C#N)C1
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Safety

RIDADR 
UN2811
HazardClass 
IRRITANT
HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P991935
Product name
Tetrahydro-2H-pyran-4-carbonitrile
Packaging
500mg
Price
$40
Updated
2021/12/16
Ark Pharm
Product number
P000155538
Product name
4-Cyanotetrahydro-4H-pyran
Purity
98%
Packaging
25g
Price
$40
Updated
2021/12/16
Ark Pharm
Product number
P000155538
Product name
4-Cyanotetrahydro-4H-pyran
Purity
98%
Packaging
10g
Price
$25
Updated
2021/12/16
Matrix Scientific
Product number
037094
Product name
Tetrahydro-2H-pyran-4-carbonitrile
Packaging
5g
Price
$25
Updated
2021/12/16
Ark Pharm
Product number
P000155538
Product name
4-Cyanotetrahydro-4H-pyran
Purity
98%
Packaging
1g
Price
$6
Updated
2021/12/16
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4-Cyanotetrahydro-4H-pyran Chemical Properties,Usage,Production

Uses

Tetrahydro-2H-Pyran-4-Carbonitrile is used in preparation of substituted Amide compounds as farnesoid X receptor modulators.

Synthesis

344329-76-6

4295-99-2

The general procedure for the synthesis of 4-cyanotetrahydropyran from tetrahydropyran-4-carboxamide was as follows: thionyl chloride (10.0 mL, 137 mmol) was slowly added to tetrahydropyran-4-carboxamide (3.0 g, 23 mmol), and the reaction mixture was stirred under reflux for 4 hr. Upon completion of the reaction, the mixture was carefully decanted onto ice and the pH was adjusted with 50% sodium hydroxide solution to 14. Subsequently, the aqueous phase was extracted with ethyl acetate (3 x 50 mL), the organic phases were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give a light yellow oily product (2.4 g, 94% yield) which did not require further purification. The structure of the product was confirmed by the following characterization data: IR (νmax, cm-1 ): 2961, 2932, 2851, 2240, 1468, 1446, 1390, 1242, 1125, 1066, 1011; 1H NMR (500 MHz, CDCl3): δ 3.91 (2H, ddd, J = 11.9, 6.3, 3.6 Hz, 2 × 3.6 Hz, 2 × 3.6 Hz, 2 × 3.9, 6.3, 3.6 Hz, 2 × 3.6 Hz). 3.6 Hz, 2×2-HA), 3.61 (2H, ddd, J = 11.9, 7.8, 3.3 Hz, 2×2-HB), 2.91-2.85 (1H, m, 4-H), 1.99-1.92 (2H, m, 2×3-HA), 1.91-1.84 (2H, m, 2×3-HB); 13C NMR (75 MHz, CDCl3): δ 121.2, 65.6, 28.9, 25.3; HRMS (ESI+): calculated value C6H10NO ([M+H]+): 112.0756, measured value: 112.0754, Δ -1.8 ppm.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 11, p. 2629 - 2635
[2] Patent: US2007/111984, 2007, A1. Location in patent: Page/Page column 45
[3] Journal of the American Chemical Society, 1943, vol. 65, p. 370
[4] Patent: US2009/253679, 2009, A1. Location in patent: Page/Page column 54-55

4-Cyanotetrahydro-4H-pyran Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Cyanotetrahydro-4H-pyran Suppliers

Canada 1 China 150 Finland 1 France 3 Germany 1 India 4 Russia 1 Ukraine 1 United Kingdom 1 United States 14 Global 177
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38
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View Lastest Price from 4-Cyanotetrahydro-4H-pyran manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Cyanotetrahydro-4H-pyran 4295-99-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-22
Henan Aochuang Chemical Co.,Ltd.
Product
4-Cyanotetrahydro-4H-pyran 4295-99-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Dideu Industries Group Limited
Product
4-Cyanotetrahydro-4H-pyran 4295-99-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-29

4295-99-2, 4-Cyanotetrahydro-4H-pyranRelated Search:

Tetrahydro-4H-pyran-4-one Methylene dithiocyanate Centchroman ETHYL 2-CYANOACRYLATE Tetrahydropyran Tetrahydropyran-4-carbaldehyde 4-(3-BROMOPHENYL)TETRAHYDROPYRAN-4-CARBONITRILE ethyl 4-cyanotetrahydro-2H-pyran-4-carboxylate 4-phenyltetrahydro-2H-pyran-4-carbonitrile 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2,2-Dimethyl-4-cyanotetrahydropyran-4-ol 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBONITRILE 4-Cyanotetrahydro-4H-pyran

  • 4-CYANOTETRAHYDRO-4H-PYRAN
  • 4-Cyanotetrahydropyran
  • tetrahydro-2H-pyran-4-carbonitrile(SALTDATA: FREE)
  • Tetrahydro-pyran-4-carbonitrile
  • 4-cyanotetrahydropiran
  • oxane-4-carbonitrile
  • 2H-Pyran-4-carbonitrile, tetrahydro-
  • 4-Cyanotetrahydro-4H-pyran manufacturer
  • 4-Cyanotetrahydro-4H-pyran ISO 9001：2015 REACH
  • 4295-99-2