erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride

Product Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
CAS No.: 58337-38-5
Chemical Name: erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
Synonyms: rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt;erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride;erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride;erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
CBNumber: CB72130522
Molecular Formula: C14H24ClN5O
Formula Weight: 313.82626
MOL File: 58337-38-5.mol

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erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Property

Melting point:: 163-180°C
storage temp.: 2-8°C
solubility: DMSO: >10mg/mL
form: Solid
color: Off-White to Beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E114
Product name: EHNA hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $281
Updated: 2024/03/01

Sigma-Aldrich

Product number: E114
Product name: EHNA hydrochloride
Purity: ≥98% (HPLC)
Packaging: 100mg
Price: $953
Updated: 2024/03/01

Cayman Chemical

Product number: 13352
Product name: EHNA (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 13352
Product name: EHNA (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $60
Updated: 2024/03/01

Cayman Chemical

Product number: 13352
Product name: EHNA (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $137
Updated: 2024/03/01

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erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does not inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). Potent PDE-2 inhibitor.

Uses

EHNA hydrochloride has been used to treat microexplant culture to examine the direction and the motor responsible for the movement of autophagosomes in axons. It has also been used in nucleoside supplementation to inhibit the breakdown of deoxyadenosine by the enzyme adenosine deaminase.

Uses

A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM).

Definition

ChEBI: (2R,3S)-EHNA hydrochloride is a hydrochloride salt obtained by reaction of (2R,3S)-EHNA with one equivalent of hydrochloric acid. Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and an EC 3.5.4.4 (adenosine deaminase) inhibitor. It contains a (2R,3S)-EHNA(1+).

General Description

EHNA is an adenosine deaminase inhibitor. It possesses antitumor action.

storage

Room temperature

erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Suppliers

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58337-38-5, erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochlorideRelated Search:

Adenine hydrochloride

erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride

erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride

rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt

erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride

58337-38-5

C14H23N5OXHCl

C14H23N5OClH

Selective inhibitor of cGMP-stimulated phosphodiesterase.

Inhibitors, Nucleotides, Bases & Related Reagents