erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
- Product Name
- erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
- CAS No.
- 58337-38-5
- Chemical Name
- erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
- Synonyms
- rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt;erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride;erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride;erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
- CBNumber
- CB72130522
- Molecular Formula
- C14H24ClN5O
- Formula Weight
- 313.82626
- MOL File
- 58337-38-5.mol
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Property
- Melting point:
- 163-180°C
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- Solid
- color
- Off-White to Beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- E114
- Product name
- EHNA hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $281
- Updated
- 2024/03/01
- Product number
- E114
- Product name
- EHNA hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 100mg
- Price
- $953
- Updated
- 2024/03/01
- Product number
- 13352
- Product name
- EHNA (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 13352
- Product name
- EHNA (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $60
- Updated
- 2024/03/01
- Product number
- 13352
- Product name
- EHNA (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $137
- Updated
- 2024/03/01
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Solid
Uses
A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does not inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). Potent PDE-2 inhibitor.
Uses
EHNA hydrochloride has been used to treat microexplant culture to examine the direction and the motor responsible for the movement of autophagosomes in axons. It has also been used in nucleoside supplementation to inhibit the breakdown of deoxyadenosine by the enzyme adenosine deaminase.
Uses
A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM).
Definition
ChEBI: (2R,3S)-EHNA hydrochloride is a hydrochloride salt obtained by reaction of (2R,3S)-EHNA with one equivalent of hydrochloric acid. Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and an EC 3.5.4.4 (adenosine deaminase) inhibitor. It contains a (2R,3S)-EHNA(1+).
General Description
EHNA is an adenosine deaminase inhibitor. It possesses antitumor action.
storage
Room temperature
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Suppliers
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