ChemicalBook > CAS DataBase List > AMBRETTOLIDE

AMBRETTOLIDE

Aroma

Product Name: AMBRETTOLIDE
CAS No.: 28645-51-4
Chemical Name: AMBRETTOLIDE
Synonyms: Nsc 31697;FEMA 2555;AMBRETTOLIDE;Fema no. 2555;Einecs 249-120-7;HEXADECEN-8-OLIDE;Ambrettolide 1832003;OMEGA-6-HEXADECENLACTONE;Oxacycloheptadec-10-en-2-on;1-oxacycloheptadec-10-en-2-one
CBNumber: CB7213218
Molecular Formula: C16H28O2
Formula Weight: 252.39
MOL File: 28645-51-4.mol

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AMBRETTOLIDE Property

Boiling point:: 185-190 °C16 mm Hg(lit.)
Density: 0.956 g/mL at 25 °C(lit.)
vapor pressure: 0.003Pa at 25℃
refractive index: n20/D 1.479(lit.)
FEMA: 4145 | ISOAMBRETTOLIDE
Flash point:: >230 °F
storage temp.: Refrigerator
solubility: Chloroform (Sparingly), Methanol (Sparingly)
form: Oil
color: Clear Colorless
Odor: at 10.00 % in dipropylene glycol. sweet musk ambrette fruity waxy fatty
Odor Type: musk
Water Solubility: 15μg/L at 25℃
JECFA Number: 1991
LogP: 6.7 at 23℃
EPA Substance Registry System: Oxacycloheptadec-10-en-2-one (28645-51-4)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26-36
WGK Germany: 2
Toxicity: Both the acute oral LD₅₀ value in rats and the acute dermal LD₅₀ value in rabbits exceeded 5 g/kg(Wohl, 1974).

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W414522
Product name: Isoambrettolide
Purity: ≥97%, FG
Packaging: 1 unit
Price: $49.02
Updated: 2025/07/31

Sigma-Aldrich

Product number: W414522
Product name: Isoambrettolide
Purity: ≥97%, FG
Packaging: 1 unit
Price: $49.02
Updated: 2025/07/31

Sigma-Aldrich

Product number: W414522
Product name: Isoambrettolide
Purity: ≥97%, FG
Packaging: 100g
Price: $68.59
Updated: 2025/07/31

Sigma-Aldrich

Product number: W414522
Product name: Isoambrettolide
Purity: ≥97%, FG
Packaging: 1kg
Price: $400
Updated: 2025/07/31

Sigma-Aldrich

Product number: W414522
Product name: Isoambrettolide
Purity: ≥97%, FG
Packaging: SAMPLE-K
Price: $50
Updated: 2024/03/01

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AMBRETTOLIDE Chemical Properties,Usage,Production

Aroma

Colorless, somewhat viscous oil with rich and extremely tenacious floral-musky, sweet odor.
Ambrettolide is one of the finest fixatives among the distinguished group of those showing a synergistic and amplifying effect upon perfumes and flavors. At the same time it increases the diffusiveness of fragrances in which it is incorporated. Its fixative effect is easily recognized by the fact that solutions of 0.01% ~ Ambrettolide (or even less) in slightly diluted alcohol show practically no odor of alcohol, only a faint, floral-musky, sweet and pleasant odor of the lactone. A. is particularly useful in fragrance types of delicately floral, mildly animal or Ambre-like type.

Chemical Properties

AMBRETTOLIDE is not reported as being found in nature, in contrast to (Z)-7-hexadecen-16-olide, which occurs in ambrette seed oil and which is also referred to as ambrettolide. It is a colorless to slightly yellow liquid, d²⁰₄ 0.949–0.957, n²⁰_D 1.477–1.482, with an intense and powerful musk odor. It is prepared by treating aleuritic acid (9,10,16-trihydroxyhexadecanoic acid) with trimethyl orthoformate to give a dioxolane derivative. Reaction with acetic anhydride yields ??-acetoxy (E)-9-hexadecenoic acid methyl ester. This is lactonized with potassium hydroxide to give the title compound .

Occurrence

Found in oil of ambrette seed[Givaudan Index, 1961).

Uses

Ambrettolide is a macrocyclic lactone that naturally occurs in ambrette seed oil. Ambrettolide is nontoxic, has a musky odour, and is commonly used as a fixative in perfume formulations.

Definition

ChEBI: Isoambrettolide is a macrolide.

Preparation

From bromohexadecenoic acid(Bedoukian, 1967).

Production Methods

Many patented methods are known, few are commercially feasible. From Bromo hexadecenoic acid, or from Dihydroxy palmitic acid, or from Aleuritic acid, or from Juniperic acid, etc.

Flammability and Explosibility

Not classified

AMBRETTOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AMBRETTOLIDE manufacturers

Shandong Deshang Chemical Co., Ltd.

Product: AMBRETTOLIDE 28645-51-4
Price: US $15.00-10.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 10 tons
Release date: 2024-06-19

Career Henan Chemical Co

Product: AMBRETTOLIDE 28645-51-4
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: ask
Release date: 2019-12-18

28645-51-4, AMBRETTOLIDERelated Search:

OXACYCLOHEPTADEC-10-EN-2-ONE, TECH cis-Iso ambrettolide OXACYCLOHEPTADEC-10-EN-2-ONE oxacycloheptadec-14-en-2-one AMBRETTOLIDE LG,(Z)-Oxacycloheptadec-8-en-2-on oxacycloheptadec-13-en-2-one Ambrettolide, Oxacycloheptadec-10-en-2-one,oxacycloheptadec-7-en-2-one ,Ambrettolide, Oxacycloheptadec-10-en-2-one,OXACYCLOHEPTADEC-8-EN-2-ONE,AMBRETTOLIDE

AMBRETTOLIDE

OMEGA-6-HEXADECENLACTONE

Oxacycloheptadec-10-en-2-on

16-Hydroxy-9-hexadecenoic acid lactone

1-Oxacycloheptadeca-10-en-2-one

Δ9-Isooambrettolic acid lactone

9-Hexadecenoic acid, 16-hydroxy-, o-lactone

Einecs 249-120-7

Fema no. 2555

Nsc 31697

Omega-6-hexadecenlactone (natural)

(E)-oxacycloheptadec-10-en-2-one

16-HYDROXY-7-HEXADECENOIC ACID O-LACTONE

HEXADECEN-8-OLIDE

FEMA 2555

AMBRETTOLIDE 99% CAS 28645-51-4

Ambrettolide 1832003

1-oxacycloheptadec-10-en-2-one

28645-51-4