740 Y-P
- Product Name
- 740 Y-P
- CAS No.
- 1236188-16-1
- Chemical Name
- 740 Y-P
- Synonyms
- 740 Y-P;740YPDGFR;740 Y-P TFA;PDGFR 740Y-P;740 Y-P, >96%;PI 3-kinase activator;740 Y-P (PDGFR 740Y-P);740 Y-P，740YPDGFR，PDGFR 740Y-P;740 Y-P,740YPDGFR,PDGFR 740Y-P, >96%;RQIKIWFQNRRMKWKKSDGGYMDMS (Modifications: Tyr-21 = pTyr)
- CBNumber
- CB7223857
- Molecular Formula
- C141H222N43O39PS3
- Formula Weight
- 3270.7
- MOL File
- 1236188-16-1.mol
740 Y-P Property
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- -20°C, protect from light
- solubility
- ≥163.54 mg/mL in DMSO; insoluble in EtOH; ≥4.87 mg/mL in H2O
- form
- solid
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{Tyr(PO2)}-Met-Asp-Met-Ser
- InChIKey
- XCGMILZGRGEWHL-QYGSNONCSA-N
N-Bromosuccinimide Price
- Product number
- 22598
- Product name
- 740 Y-P
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 22598
- Product name
- 740 Y-P
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 254452
- Product name
- 740 Y-P
- Packaging
- 1mg
- Price
- $593
- Updated
- 2021/12/16
- Product number
- B5246
- Product name
- 740Y-P
- Packaging
- 1mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-7808
- Product name
- 740Y-P
- Purity
- 99.03%
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
740 Y-P Chemical Properties,Usage,Production
Uses
740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone[1].
in vivo
740 Y-P is not only internalised in living cells but can also interact with p85 in vivo[1].740 Y-P (intraperitoneal?injection; 10 mg/kg; 6 weeks) decreases the degree of ROS levels in Aβ(25-32) treated hippocampal tissues and increases the extent of AKT and PI3K phosphorylation in alzheimer’s disease (AD) rat model[3].
IC 50
PI3K
storage
Store at -20°C
References
[1] Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. DOI:10.1006/bbrc.1998.9444
[2] Xiaoli Feng, et al. Graphene Oxide Induces p62/SQSTM-dependent Apoptosis Through the Impairment of Autophagic Flux and Lysosomal Dysfunction in PC12 Cells. Acta Biomater.?2018 Nov;81:278-292. DOI:10.1016/j.actbio.2018.09.057
[3] Zhiqing Sun, et al. GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease. J Alzheimers Dis.?2020;76(4):1513-1526. DOI:10.3233/JAD-191032
740 Y-P Preparation Products And Raw materials
Raw materials
Preparation Products
740 Y-P Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77