740 Y-P

Product Name: 740 Y-P
CAS No.: 1236188-16-1
Chemical Name: 740 Y-P
Synonyms: 740 Y-P;740YPDGFR;740 Y-P TFA;PDGFR 740Y-P;740 Y-P, >96%;PI 3-kinase activator;740 Y-P (PDGFR 740Y-P);740 Y-P，740YPDGFR，PDGFR 740Y-P;740 Y-P,740YPDGFR,PDGFR 740Y-P, >96%;RQIKIWFQNRRMKWKKSDGGYMDMS (Modifications: Tyr-21 = pTyr)
CBNumber: CB7223857
Molecular Formula: C141H222N43O39PS3
Formula Weight: 3270.7
MOL File: 1236188-16-1.mol

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740 Y-P Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: -20°C, protect from light
solubility: ≥163.54 mg/mL in DMSO; insoluble in EtOH; ≥4.87 mg/mL in H2O
form: solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-{Tyr(PO2)}-Met-Asp-Met-Ser
InChIKey: XCGMILZGRGEWHL-QYGSNONCSA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22598
Product name: 740 Y-P
Purity: ≥95%
Packaging: 500μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 22598
Product name: 740 Y-P
Purity: ≥95%
Packaging: 1mg
Price: $230
Updated: 2024/03/01

Usbiological

Product number: 254452
Product name: 740 Y-P
Packaging: 1mg
Price: $593
Updated: 2021/12/16

ApexBio Technology

Product number: B5246
Product name: 740Y-P
Packaging: 1mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-7808
Product name: 740Y-P
Purity: 99.03%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

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740 Y-P Chemical Properties,Usage,Production

Uses

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone[1].

in vivo

740 Y-P is not only internalised in living cells but can also interact with p85 in vivo^[1].740 Y-P (intraperitoneal?injection; 10 mg/kg; 6 weeks) decreases the degree of ROS levels in Aβ(25-32) treated hippocampal tissues and increases the extent of AKT and PI3K phosphorylation in alzheimer’s disease (AD) rat model^[3].

IC 50

PI3K

storage

Store at -20°C

References

[1] Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide. DOI:10.1006/bbrc.1998.9444
[2] Xiaoli Feng, et al. Graphene Oxide Induces p62/SQSTM-dependent Apoptosis Through the Impairment of Autophagic Flux and Lysosomal Dysfunction in PC12 Cells. Acta Biomater.?2018 Nov;81:278-292. DOI:10.1016/j.actbio.2018.09.057
[3] Zhiqing Sun, et al. GABAB Receptor-Mediated PI3K/Akt Signaling Pathway Alleviates Oxidative Stress and Neuronal Cell Injury in a Rat Model of Alzheimer's Disease. J Alzheimers Dis.?2020;76(4):1513-1526. DOI:10.3233/JAD-191032

740 Y-P Preparation Products And Raw materials

Raw materials

Preparation Products

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740 Y-P Suppliers

China 106 United Kingdom 1 United States 8 Global 115

MedChemexpress LLC

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MedChemExpress

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1236188-16-1, 740 Y-PRelated Search:

740 Y-P

RQIKIWFQNRRMKWKKSDGGYMDMS (Modifications: Tyr-21 = pTyr)

PDGFR 740Y-P

740 Y-P, >96%

740 Y-P,740YPDGFR,PDGFR 740Y-P, >96%

740YPDGFR

L-Serine, L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartylglycylglycyl-O-phosphono-L-tyrosyl-L-methionyl-L-α-aspartyl-L-methionyl-

740 Y-P (PDGFR 740Y-P)

L-Arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartylglycylglycyl-O-phosphono-L-tyrosyl-L-methionyl-L-α-aspartyl-L-methionyl-L-serine

VSMC,PI3K,inhibit,alzheimer’s disease,aortic,p85 binding,SH2,740 Y-P,Autophagy,740 Y P,cancer,740 YP,peptide,Inhibitor,thoracic,Phosphoinositide 3-kinase

740 Y-P，740YPDGFR，PDGFR 740Y-P

740 Y-P TFA

PI 3-kinase activator

1236188-16-1

C141H222N43O39PS3

Protein Kinase