4-BROMO-BENZAMIDINE
- Product Name
- 4-BROMO-BENZAMIDINE
- CAS No.
- 22265-36-7
- Chemical Name
- 4-BROMO-BENZAMIDINE
- Synonyms
- p-Bromobenzamidine;CHEMBRDG-BB 4012620;4-BROMO-BENZAMIDINE;4-bromobenzammidine;4-BROMOBENZAMIDINE HCL;4-BroMo-benzaMidine HCl salt;4-Bromobenzenecarboximidamide;BenzenecarboxiMidaMide, 4-broMo-;4-bromobenzenecarboximidamide 1HCl;4-BROMOBENZENECARBOXIMIDAMIDE HYDROCHLORIDE
- CBNumber
- CB7230107
- Molecular Formula
- C7H7BrN2
- Formula Weight
- 199.05
- MOL File
- 22265-36-7.mol
4-BROMO-BENZAMIDINE Property
- Melting point:
- 218℃
- Boiling point:
- 261℃
- Density
- 1.62
- Flash point:
- 112℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.39±0.50(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B677810
- Product name
- 4-Bromo-benzamidine
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB151084
- Product name
- 4-Bromo-benzamidine
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB151084
- Product name
- 4-Bromo-benzamidine
- Packaging
- 500mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FB151084
- Product name
- 4-Bromo-benzamidine
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 1266AB
- Product name
- 4-Bromobenzimidamide
- Packaging
- 5g
- Price
- $227
- Updated
- 2021/12/16
4-BROMO-BENZAMIDINE Chemical Properties,Usage,Production
Synthesis
55368-42-8
22265-36-7
The general procedure for the synthesis of 4-bromobenzamidine hydrochloride from 4-bromobenzamidine hydrochloride was as follows: first, 4-bromobenzamidine hydrochloride (6a, 707 mg) was treated with 5 M aqueous sodium hydroxide (8 mL), followed by extraction with chloroform. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a colorless solid (472 mg). Next, the resulting solid was dissolved in ethanol (5 mL), ethyl propargylate (0.27 mL) was added and the reaction mixture was heated to 60 °C. Then, a solution of potassium hydroxide (175 mg) in ethanol (4 mL) was added dropwise over 15 minutes. The reaction mixture was further heated to 80 °C and stirred at this temperature for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature, acidified by addition of 1 M hydrochloric acid (10 mL) and the precipitate was collected by filtration. The precipitate was washed with water and dried under vacuum at 50 °C overnight to give 7 g (267 mg, 35% yield) of the target product as a light brown solid. The product was characterized by 1H NMR (DMSO-d6): δ 6.25-5.50 (1H, m), 7.74 (2H, d, J = 8.3 Hz), 7.95-8.25 (3H, m), 12.50-13.20 (1H, br); FAB-MS m/z 251,253 [(M + H)+].
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 7, p. 2369 - 2375
[2] Patent: EP2862856, 2015, A1. Location in patent: Paragraph 0651; 0652
[3] Tetrahedron Letters, 2018, vol. 59, # 4, p. 361 - 364
4-BROMO-BENZAMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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