1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE

Product Name
1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
CAS No.
100991-92-2
Chemical Name
1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
Synonyms
1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE;2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride;1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride enzyme inhibitor;3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R)-;(2R,3R,4R)-3,4-Dihydroxy-2-(hydroxymethyl)pyrrolidine hydrochloride
CBNumber
CB7230309
Molecular Formula
C5H12ClNO3
Formula Weight
169.61
MOL File
Mol file
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1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Property

Melting point:
110-112 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))
storage temp. 
2-8°C
solubility 
DMSO: 10 mg/ml; PBS (pH 7.2): 1 mg/ml
form 
A crystalline solid
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1542
Product name
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
Purity
enzyme inhibitor
Packaging
10mg
Price
$762
Updated
2024/03/01
Sigma-Aldrich
Product number
D1542
Product name
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride
Purity
enzyme inhibitor
Packaging
25mg
Price
$1700
Updated
2024/03/01
Cayman Chemical
Product number
20939
Product name
1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
20939
Product name
1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
20939
Product name
1,4-dideoxy-1,4-imino-D-Arabinitol (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$292
Updated
2024/03/01
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1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

1,4-dideoxy-1,4-imino-D-Arabinitol (DAB) is an inhibitor of glycogen phosphorylase, a key enzyme in glycogenolysis. It inhibits glycogenolysis in isolated liver cells (IC50 = 1.0 μM) and in homogenates of cerebral cortex and cerebellum (IC50s = 463 and 383 nM, respectively). DAB is used to inhibit glycogenolysis, in liver and in brain, in various animal models.

Uses

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride has been used as an α-glucosidase (GAA) inhibitor.

General Description

1,4-Dideoxy-1,4-imino-D-arabinitol is a naturally occurring pyrrolidine alkaloid. It is found in Arachniodes standishii and Angylocalyx boutiqueanus.

Biochem/physiol Actions

Inhibitor of glycogen phosphorylase and α-glucosidases.

1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE Suppliers

China 18 Japan 1 United Kingdom 2 United States 5 Global 26
Sigma-Aldrich
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Shandong Ono Chemical Co., Ltd.
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Energy Chemical
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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+86-18521732826
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TargetMol Chemicals Inc.
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Absin Bioscience Inc.
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Express Technology Co., Ltd.
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100991-92-2, 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDERelated Search:

D-arabinitol 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL

  • 1,4-DIDEOXY-1,4-IMINO-D-ARABINITOL HYDROCHLORIDE
  • 2-Hydroxymethyl-3,4-pyrrolidinediol hydrochloride
  • (2R,3R,4R)-3,4-Dihydroxy-2-(hydroxymethyl)pyrrolidine hydrochloride
  • 3,4-Pyrrolidinediol, 2-(hydroxymethyl)-, hydrochloride, (2R,3R,4R)-
  • 1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride enzyme inhibitor
  • 100991-92-2