ChemicalBook > CAS DataBase List > 1,3-Dihydro-3,3-dimethyl-2H-indol-2-one
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one
- Product Name
- 1,3-Dihydro-3,3-dimethyl-2H-indol-2-one
- CAS No.
- 19155-24-9
- Chemical Name
- 1,3-Dihydro-3,3-dimethyl-2H-indol-2-one
- Synonyms
- 3,3-DiMethyloxindole;Oxindole, 3,3-diMethyl-;3,3-DIMETHYLINDOLIN-2-ONE;3,3-dimethyl-2-indolinone;3,3-dimethyl-3H-indol-2-ol;2-Indolinone, 3,3-diMethyl-;3,3-dimethyl-1H-indol-2-one;3,3-DIMETHYL-1,3-DIHYDRO-INDOL-2-ONE;3,3-diMethyl-2,3-dihydro-1H-indol-2-one;3,3-dimethyl-1,3-dihydro-2H-indol-2-one
- CBNumber
- CB72308789
- Molecular Formula
- C10H11NO
- Formula Weight
- 161.2
- MOL File
- 19155-24-9.mol
More
Less
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one Property
- Melting point:
- 154.3°C
- Boiling point:
- 287.51°C (rough estimate)
- Density
- 1.078
- refractive index
- 1.5200 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 14.85±0.40(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C10H11NO/c1-10(2)7-5-3-4-6-8(7)11-9(10)12/h3-6H,1-2H3,(H,11,12)
- InChIKey
- KEZHRKOVLKUYCQ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC=C2)C(C)(C)C1=O
More
Less
Safety
- HS Code
- 2933998090
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- D476405
- Product name
- 3,3-Dimethyloxindole
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
AK Scientific
- Product number
- W4107
- Product name
- 3,3-Dimethylindolin-2-one
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD127080
- Product name
- 3,3-Dimethyl-1,3-dihydro-2H-indol-2-one
- Packaging
- 1g
- Price
- $255
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD127080
- Product name
- 3,3-Dimethyl-1,3-dihydro-2H-indol-2-one
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR964406
- Product name
- 3,3-Dimethylindolin-2-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
More
Less
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one Chemical Properties,Usage,Production
Uses
3,3-Dimethyloxindole is used as an isoquinolin-1-amine based ROCK-I inhibitors. Also used in the preparation of a P2Y1 antagonists as effacacious antiplatelet agents.
Synthesis Reference(s)
Tetrahedron, 48, p. 7297, 1992 DOI: 10.1016/S0040-4020(01)88268-5
Synthesis
59-48-3
74-88-4
19155-24-9
To a solution of 2-indolone (5 g, 37.55 mmol) and lithium chloride (5.6 g, 131.4 mmol) in tetrahydrofuran (100 mL) was added n-butyllithium (2.5 M, 30 mL) dropwise at -78 °C. The reaction mixture was stirred at -78 °C for 20 min, followed by the addition of iodomethane (4.8 mL, 75.1 mmol). The reaction system was warmed to 25 °C and stirred overnight. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (100 mL) and extracted with ethyl acetate (100 mL x 3). The organic phases were combined, washed sequentially with water (100 mL) and saturated saline (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 8:1, v/v) to afford 1,2-dihydro-3,3-dimethyl-2-oxo-3H-indole as a white solid (2.92 g, 48.3% yield). Mass spectrum (ESI, positive ion mode) m/z: 162 [M+H]+; NMR hydrogen spectrum (CDCl3) δ (ppm): 9.23 (s, 1H), 7.21-7.18 (m, 2H), 7.04 (t, 1H), 6.96 (d, 1H), 1.41 (s, 6H).
References
[1] Patent: WO2014/89324, 2014, A1. Location in patent: Paragraph 0202
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 18, p. 4929 - 4931
[3] Patent: US2007/72897, 2007, A1. Location in patent: Page/Page column 66
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 419 - 430
[5] ChemMedChem, 2016, vol. 11, # 5, p. 497 - 508
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one Suppliers
- Tel
- 021-58111238 18930958102
- Fax
- 021-58111238
- sales@taifupharm.com
- Country
- China
- ProdList
- 509
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 021-54849683 13601642561
- Fax
- +86-21-54375689
- sales@keepontech.com
- Country
- China
- ProdList
- 998
- Advantage
- 59
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- +86-021-58975553
- Fax
- +86-021-58975554
- sales@cooperpharm.com
- Country
- China
- ProdList
- 1210
- Advantage
- 56
- Tel
- 021-57171705 13817537615
- Fax
- QQ3095748324
- sales@run-biotech.com
- Country
- China
- ProdList
- 2332
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 15121041756
- xingui2022@126.com
- Country
- China
- ProdList
- 9986
- Advantage
- 58
- Tel
- 微信 17321281695 18019252918
- Fax
- 17321281695
- sale@amkchem.com
- Country
- China
- ProdList
- 15136
- Advantage
- 55
- Tel
- 02161555100
- Fax
- -
- Country
- China
- ProdList
- 820
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
- Tel
- 13391076197
- tombiopharma@163.com
- Country
- China
- ProdList
- 4987
- Advantage
- 55
- Tel
- 28-87999436 02887999436
- Fax
- QQ:2746983436
- sales@sano-chem.com
- Country
- China
- ProdList
- 3795
- Advantage
- 55
- Tel
- 86-(0)21-31261262 373522135
- Fax
- 86-(0)21-33250524
- sales@novochemy.com
- Country
- China
- ProdList
- 6498
- Advantage
- 58
- Tel
- 13162380607
- Fax
- QQ:1696175688
- 1696175688@qq.com
- Country
- China
- ProdList
- 817
- Advantage
- 55
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7991
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 086-0519-83990708 18915800124
- Fax
- 0519-83990708
- info@pbpharm.com
- Country
- China
- ProdList
- 487
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28785
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9721
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 021-000000
- admin@jingshipharmatech.com
- Country
- China
- ProdList
- 9853
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 15721176654
- 1815535157@qq.com
- Country
- China
- ProdList
- 881
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- 021-50676523 18019098996
- info@acelybio.com
- Country
- China
- ProdList
- 3960
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- +86-0571-88938639 +8617705817739
- Fax
- +86-571-88938652，+86-571- 88492614
- info@dycnchem.com
- Country
- China
- ProdList
- 52846
- Advantage
- 58
- Tel
- 0519-83990708
- info@pbpharm.com
- Country
- CHINA
- ProdList
- 498
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- sales@accelachem.com
- Country
- China
- ProdList
- 10467
- Advantage
- 58
- Tel
- 0371-55289822 18737195735
- Fax
- QQ:483339295
- 483339295@qq.com
- Country
- China
- ProdList
- 7587
- Advantage
- 58
- Tel
- +8618523575427
- sales@conier.com
- Country
- China
- ProdList
- 49975
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0086-371-86658258
- factory@coreychem.com
- Country
- China
- ProdList
- 29798
- Advantage
- 58
- Tel
- 021-58099077-8041 18601625411
- sales@birdotech.com
- Country
- China
- ProdList
- 9764
- Advantage
- 58
- Tel
- +8613580539051
- joe@yuhengpharm.com
- Country
- CHINA
- ProdList
- 21142
- Advantage
- 58
- Tel
- 0519-68985668 13685222090
- Fax
- qq735434464
- sales@kechem.cn
- Country
- China
- ProdList
- 26028
- Advantage
- 58
- Tel
- 650-6922368
- sales@achemblock.com
- Country
- China
- ProdList
- 2992
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 13180081292 13180081292
- contact@wetogethermed.com
- Country
- China
- ProdList
- 7943
- Advantage
- 58
- Tel
- 1483287082 19962651230
- sales@allbiopharm.com
- Country
- China
- ProdList
- 1529
- Advantage
- 58
- Tel
- 183-0212-4410 18302124410
- Djt18302124410@163.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 2383948258 19172820304
- 2383948258@qq.com
- Country
- China
- ProdList
- 12987
- Advantage
- 58
More
Less
View Lastest Price from 1,3-Dihydro-3,3-dimethyl-2H-indol-2-one manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 1,3-Dihydro-3,3-dimethyl-2H-indol-2-one 19155-24-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
Career Henan Chemical Co
- Product
- 1,3-Dihydro-3,3-dimethyl-2H-indol-2-one 19155-24-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02
19155-24-9, 1,3-Dihydro-3,3-dimethyl-2H-indol-2-oneRelated Search:
Indolidan
3,3-Bis(3-methyl-4-hydroxyphenyl)indoline-2-on
oxyphenisatine di(acetate)
GELSEMINE
Rhein
GELSEMINE HYDROCHLORIDE
Amedalin
3,3-BIS(P-HYDROXYPHENYL)OXINDOLE
1,3-Dihydro-3,3-dimethyl-2H-indol-2-one
BUTTPARK 124\40-98
3,3-BIS-(3,5-DIMETHYL-4-HYDROXYPHENYL)-1,3-DIHYDRO-INDOL-2-ONE
1-BENZYL-3-(BROMOMETHYL)-3-PHENYLINDOLIN-2-ONE
BUTTPARK 124\40-99
BUTTPARK 58\40-88
AKOS UB-20403
BUTTPARK 58\40-89
5-HYDROXY-3,3-DIMETHYL-1,3-DIHYDRO-INDOL-2-ONE
BUTTPARK 125\40-01