ChemicalBook > CAS DataBase List > Ramiprilat

Ramiprilat

Product Name
Ramiprilat
CAS No.
87269-97-4
Chemical Name
Ramiprilat
Synonyms
Ramipley;RAMIPRILAT;Ramiprilate;HOE 498 Diacid;Ramipril Diacid;RAMIPRILAT HYDRATE;Ramipril Impurity E;Ramiprilat USP/EP/BP;RaMipril EP IMpurity E;RamiprilEPImpurityE-d5
CBNumber
CB7231407
Molecular Formula
C21H28N2O5
Formula Weight
388.46
MOL File
87269-97-4.mol
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Ramiprilat Property

Melting point:
139-141°C
Boiling point:
632.2±55.0 °C(Predicted)
Density 
1.273±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
2.20±0.10(Predicted)
color 
White to Pale Yellow
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-37/39
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15557
Product name
Ramiprilat
Purity
≥98%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
15557
Product name
Ramiprilat
Purity
≥98%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
15557
Product name
Ramiprilat
Purity
≥98%
Packaging
10mg
Price
$477
Updated
2024/03/01
Usbiological
Product number
464518
Product name
Ramiprilat|
Packaging
5mg
Price
$368
Updated
2021/12/16
TRC
Product number
R111010
Product name
Ramiprilat
Packaging
5mg
Price
$235
Updated
2021/12/16
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Ramiprilat Chemical Properties,Usage,Production

Description

Ramiprilat is the active metabolite of ramipril and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported to interfere with the targeting of B2 kinin receptors to endothelial cell membranes further preventing bradykinin signaling. In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.

Chemical Properties

White to Off-White Solid

Uses

A metabolite of Ramipril (R111000).

Uses

Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)

Definition

ChEBI: A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

in vitro

pretreatment with ramiprilat could significantly attenuate the recovery of b2 kinin receptors in while increasing that from membranes lacking caveolin, and such effect was not because of the inhibition of bradykinin degradation. ramiprilat could also decrease [3h]bradykinin binding to cr membranes. in addition, ramiprilat treatment led to reactivation of the b2 receptor in bradykinin-stimulated cells [1].

in vivo

in previous animal study, when compared with the control rats, diabetic rats showed decreased creatinine clearance rate, increased urinary protein excretion and blood pressure, as well as development of tubulointerstitial fibrosis, glomerulosclerosis, and inflammatory cell infiltration. furthermore, the blocking angiotensin ii with ramipril (the prodrug of ramiprilat) was able to significantly improve all of these parameters [2].

References

[1] t. benzing, i. fleming, a. blaukat, et al. angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the b2 kinin receptor within the plasma membrane of native endothelial cells. circulation 99(15), 2034-2040 (1999).
[2] li c, yang cw, park cw, ahn hj, kim wy, yoon kh, suh sh, lim sw, cha jh, kim ys, kim j, chang ys, bang bk. long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats. kidney int. 2003 feb;63(2):454-63.
[3] warner gt, perry cm. ramipril: a review of its use in the prevention of cardiovascular outcomes. drugs. 2002;62(9):1381-405.

Ramiprilat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ramiprilat manufacturers

Hebei Lingding Biotechnology Co., Ltd.
Product
Ramiprilat 87269-97-4
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-10-15
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Ramiprilat 87269-97-4
Price
US $2.20/KG
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20tons
Release date
2021-12-09
Dideu Industries Group Limited
Product
Ramiprilat 87269-97-4
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-10

87269-97-4, RamiprilatRelated Search:

Pyrrolidine Polyvinylpyrrolidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Ramipril Diketopiperazine Ramipril Related Compound A (30 mg) ((2S,3aS,6aS)-1-[(S)2-[[(S)-1-(methoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid) RAMIPRIL RELATED COMPOUND B (20 MG) (RAMIPRIL ISOPROPYLESTER) Ramiprilat Diketopiperazine Carboxy styrene-butadiene latex Ramipril RAMIPRIL-D3 RAMIPRILAT-D5 ACYL-B-D-GLUCURONIDE RAMIPRIL-D5 ACYL-B-D-GLUCURONIDE RAMIPRILAT ACYL-B-D-GLUCURONIDE RAMIPRILAT-D3 (1R) RAMIPRILAT-D5 Ramiprilat Diketopiperazine-d5 RAMIPRILAT-D5

  • RAMIPRILAT
  • RAMIPRILAT HYDRATE
  • Ramiprilat, ammonium salt
  • Ramipril EP Impurity E (Ramiprilat)
  • Ramipril Impurity V:Ramiprilat
  • Ramipril EP Imp E (acid)
  • (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid
  • HOE 498 Diacid
  • Ramipril Diacid
  • (2S,3aS,6aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • (2S,3aβ,6aβ)-1-[(S)-2-[[(S)-1-Carboxy-3-phenylpropyl]amino]propionyl]octahydrocyclopenta[b]pyrrole-2α-carboxylic acid
  • Ramiprilate
  • ramiprilat:(2s,3as,6as)-1-((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta(b)pyrrole-2-carboxylic acid
  • (2S,3aS,6aS)-1-[(S)-2-[[(S)-1-carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • Ramipril Impurity 1(Ramipril EP Impurity E)
  • (2S,3aS,6aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid
  • RaMipril IMpurity-E (EP)
  • RaMipril EP IMpurity E
  • (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Car
  • Ramipril impurity Ⅴ(Ramiprilat)
  • Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,6aS)-
  • Ramiprilat USP/EP/BP
  • Ramipril Impurity 1 （EP Impurity E）
  • Ramipril EP Impurity E (Ramipril Diacid/ Ramiprilat)
  • Ramipley
  • Ramipril EP Impurity EQ: What is Ramipril EP Impurity E Q: What is the CAS Number of Ramipril EP Impurity E Q: What is the storage condition of Ramipril EP Impurity E Q: What are the applications of Ramipril EP Impurity E
  • Ramipril impurity Ⅴ (Ramiprilat)
  • RamiprilEPImpurityE-d5
  • Ramipril Impurity E
  • 87269-97-4
  • C21H28N2O5
  • 38846
  • Various Metabolites and Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals