ChemicalBook > CAS DataBase List > Ramiprilat

Ramiprilat

Product Name: Ramiprilat
CAS No.: 87269-97-4
Chemical Name: Ramiprilat
Synonyms: Ramipley;RAMIPRILAT;Ramiprilate;RAMIPRIL USP;HOE 498 Diacid;Ramipril Diacid;RAMIPRILAT HYDRATE;Ramipril Impurity E;Ramiprilat USP/EP/BP;Ramipril Impurity 27
CBNumber: CB7231407
Molecular Formula: C21H28N2O5
Formula Weight: 388.46
MOL File: 87269-97-4.mol

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Ramiprilat Property

Melting point:: 139-141°C
Boiling point:: 632.2±55.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 2.20±0.10(Predicted)
color: White to Pale Yellow
Stability:: Hygroscopic
InChIKey: KEDYTOTWMPBSLG-HILJTLORSA-N
SMILES: N1(C(=O)[C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)[C@H](C(O)=O)C[C@]2([H])CCC[C@]12[H]

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26-37/39

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15557
Product name: Ramiprilat
Purity: ≥98%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 15557
Product name: Ramiprilat
Purity: ≥98%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 15557
Product name: Ramiprilat
Purity: ≥98%
Packaging: 10mg
Price: $477
Updated: 2024/03/01

TRC

Product number: R111010
Product name: Ramiprilat
Packaging: 5mg
Price: $235
Updated: 2021/12/16

Usbiological

Product number: 464518
Product name: Ramiprilat|
Packaging: 5mg
Price: $368
Updated: 2021/12/16

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Ramiprilat Chemical Properties,Usage,Production

Description

Ramiprilat is the active metabolite of ramipril and functions as an angiotensin-converting enzyme inhibitor (pK_i = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported to interfere with the targeting of B₂ kinin receptors to endothelial cell membranes further preventing bradykinin signaling. In addition to its cardioprotective effects in both animal models and clinical studies, ramiprilat has been reported to inhibit matrix metalloproteinase-3 and -9 activity in isolated Crohn’s disease fistulas.

Chemical Properties

White to Off-White Solid

Uses

A metabolite of Ramipril (R111000).

Uses

Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)

Definition

ChEBI: A dipeptide that is the active metabolite of ramipril. An angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure and congestive heart failure.

in vitro

pretreatment with ramiprilat could significantly attenuate the recovery of b2 kinin receptors in while increasing that from membranes lacking caveolin, and such effect was not because of the inhibition of bradykinin degradation. ramiprilat could also decrease [3h]bradykinin binding to cr membranes. in addition, ramiprilat treatment led to reactivation of the b2 receptor in bradykinin-stimulated cells [1].

in vivo

in previous animal study, when compared with the control rats, diabetic rats showed decreased creatinine clearance rate, increased urinary protein excretion and blood pressure, as well as development of tubulointerstitial fibrosis, glomerulosclerosis, and inflammatory cell infiltration. furthermore, the blocking angiotensin ii with ramipril (the prodrug of ramiprilat) was able to significantly improve all of these parameters [2].

References

[1] t. benzing, i. fleming, a. blaukat, et al. angiotensin-converting enzyme inhibitor ramiprilat interferes with the sequestration of the b2 kinin receptor within the plasma membrane of native endothelial cells. circulation 99(15), 2034-2040 (1999).
[2] li c, yang cw, park cw, ahn hj, kim wy, yoon kh, suh sh, lim sw, cha jh, kim ys, kim j, chang ys, bang bk. long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats. kidney int. 2003 feb;63(2):454-63.
[3] warner gt, perry cm. ramipril: a review of its use in the prevention of cardiovascular outcomes. drugs. 2002;62(9):1381-405.

Ramiprilat Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ramiprilat manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Ramiprilat 87269-97-4
Price: US $2.20/KG
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20tons
Release date: 2021-12-09

Shaanxi Dideu Medichem Co. Ltd

Product: RaMiprilat 87269-97-4
Price: US $0.00-0.00/KG
Min. Order: 10g
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2019-12-25

Career Henan Chemical Co

Product: Ramiprilat 87269-97-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-13

87269-97-4, RamiprilatRelated Search:

Pyrrolidine Polyvinylpyrrolidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Ramipril Diketopiperazine Ramipril Related Compound A (30 mg) ((2S,3aS,6aS)-1-[(S)2-[[(S)-1-(methoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-octahydrocyclopenta[b]pyrrole-2-carboxylic acid) RAMIPRIL RELATED COMPOUND B (20 MG) (RAMIPRIL ISOPROPYLESTER) Ramiprilat Diketopiperazine Carboxy styrene-butadiene latex Ramipril RAMIPRIL-D3 RAMIPRILAT-D5 ACYL-B-D-GLUCURONIDE RAMIPRIL-D5 ACYL-B-D-GLUCURONIDE RAMIPRILAT ACYL-B-D-GLUCURONIDE RAMIPRILAT-D3 (1R) RAMIPRILAT-D5 Ramiprilat Diketopiperazine-d5 RAMIPRILAT-D5

RAMIPRILAT

RAMIPRILAT HYDRATE

Ramiprilat, ammonium salt

Ramipril EP Impurity E (Ramiprilat)

Ramipril Impurity V:Ramiprilat

Ramipril EP Imp E (acid)

(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid

HOE 498 Diacid

Ramipril Diacid

(2S,3aS,6aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

(2S,3aβ,6aβ)-1-[(S)-2-[[(S)-1-Carboxy-3-phenylpropyl]amino]propionyl]octahydrocyclopenta[b]pyrrole-2α-carboxylic acid

Ramiprilate

ramiprilat:(2s,3as,6as)-1-((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta(b)pyrrole-2-carboxylic acid

(2S,3aS,6aS)-1-[(S)-2-[[(S)-1-carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

Ramipril Impurity 1(Ramipril EP Impurity E)

(2S,3aS,6aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)tetrahydrocyclopenta[b]pyrrole-2-carboxylic acid

RaMipril IMpurity-E (EP)

RaMipril EP IMpurity E

(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Car

Ramipril impurity Ⅴ(Ramiprilat)

Cyclopenta[b]pyrrole-2-carboxylic acid, 1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-, (2S,3aS,6aS)-

Ramiprilat USP/EP/BP

Ramipril Impurity 1 （EP Impurity E）

Ramipril EP Impurity E (Ramipril Diacid/ Ramiprilat)

Ramipley

Ramipril EP Impurity EQ: What is Ramipril EP Impurity E Q: What is the CAS Number of Ramipril EP Impurity E Q: What is the storage condition of Ramipril EP Impurity E Q: What are the applications of Ramipril EP Impurity E

Ramipril impurity Ⅴ (Ramiprilat)

RamiprilEPImpurityE-d5

Ramipril Impurity E

(2S,3aS,6aS)-1-(((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid

(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole

RAMIPRIL USP

Ramipril Impurity 27

Ramiprilat EP7。0 99%

Ramiprilat (Ramipril Diacid)

(2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]propanoyl]octahydrocyclopenta[b]pyrrole-2-carboxylic Acid (Ramipril Diacid

Ramipril Imp. E (EP): (2S,3aS,6aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl] amino]propanoyl]octahydrocyclo penta[b]pyrrole-2-carboxylic acid (ramipril diacid)

87269-97-4

C21H28N2O5

38846

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals