ChemicalBook > CAS DataBase List > (E)-5-(2-BROMOVINYL)URACIL

(E)-5-(2-BROMOVINYL)URACIL

Product Name: (E)-5-(2-BROMOVINYL)URACIL
CAS No.: 69304-49-0
Chemical Name: (E)-5-(2-BROMOVINYL)URACIL
Synonyms: bvuracil;Ccris 5284;Brn 0744244;Brovudine 8;bromovinyluracil;Uracil Impurity 13;Brivudine Impurity 4;Brivudine Impurity F;5-(2-bromovinyl)uracil;(E)-5-(2-BROMOVINYL)URACIL
CBNumber: CB7232969
Molecular Formula: C6H5BrN2O2
Formula Weight: 217.02
MOL File: 69304-49-0.mol

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(E)-5-(2-BROMOVINYL)URACIL Property

Melting point:: 189-194 °C (dec.)(lit.)
Density: 1.881
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 7.54±0.10(Predicted)
color: Pale Beige to Beige

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Safety

WGK Germany: 2
RTECS: UV9020500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 457442
Product name: (E)-5-(2-Bromovinyl)uracil
Purity: 97%
Packaging: 250mg
Price: $753
Updated: 2023/06/20

Cayman Chemical

Product number: 21030
Product name: (E)-5-(2-Bromovinyl)uracil
Packaging: 25mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 21030
Product name: (E)-5-(2-Bromovinyl)uracil
Packaging: 50mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 21030
Product name: (E)-5-(2-Bromovinyl)uracil
Packaging: 100mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 21030
Product name: (E)-5-(2-Bromovinyl)uracil
Packaging: 250mg
Price: $299
Updated: 2024/03/01

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(E)-5-(2-BROMOVINYL)URACIL Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

(E)-5-(2-Bromovinyl)uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) that may be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner. It enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil (HY-90006) in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, increasing survival time.

References

[1] De Clercq, et al. Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. J. Med. Chem. 29(2), 213-217 (1986).

(E)-5-(2-BROMOVINYL)URACIL Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-5-(2-BROMOVINYL)URACIL Suppliers

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View Lastest Price from (E)-5-(2-BROMOVINYL)URACIL manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: (E)-5-(2-BROMOVINYL)URACIL 69304-49-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

69304-49-0, (E)-5-(2-BROMOVINYL)URACILRelated Search:

5,6-Diamino-1,3-dimethyluracil hydrate 2-(2-chloropyriMidin-5-yl)propan-2-ol 2,4-Dihydroxypyrimidine-5-carboxylic acid 6-(HYDROXYMETHYL)URACIL 6-FORMYL-URACIL MONOHYDRATE dihydro-6-imino-1,3-dimethyluracil OROTIC ACID MONOHYDRATE 5-CARBOXYCYTOSINE dihydro-6-imino-1,3-dimethyl-3H-pyrimidine-2,4,5-trione 5-oxime Tetrahydrofuryluracil Pyrimidine, 5-chloro-4-(chloromethyl)-2,6-dimethoxy- Pyrimidine, 4-(chloromethyl)-2,6-dimethoxy- sorivudine (E)-5-(2-BROMOVINYL)URACIL Brivudine 5-(BROMOVINYL) 2'-DEOXYURIDINE, [2'-3H]- 5-BROMOVINYL-2'-DEOXYURIDINE, [2-14C]- (5-[5-(2-BROMOVINYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-1-YL]-3-HYDROXYTETRAHYDROFURAN-2-YL)METHYL PIVALATE

(e)-5-(2-bromoethenyl)-2,4(1h,3h)-pyrimidinedione

5-(2-bromoethenyl)-4(1(e)-3h)-pyrimidinedione

5-(2-bromovinyl)uracil

bromovinyluracil

bvuracil

(E)-5-(2-BROMOVINYL)URACIL

5-(TRANS-2-BROMOVINYL)URACIL

5-[(E)-2-Bromoethenyl]uracil

5-[(E)-2-Bromovinyl]uracil

2,4(1H,3H)-Pyrimidinedione, 5-(2-bromoethenyl)-, (E)-

Brn 0744244

Ccris 5284

5-[(1E)-2-Bromoethenyl]-2,4(1H,3H)-pyrimidinedione

2,4(1H,3H)-PyriMidinedione, 5-[(1E)-2-broMoethenyl]-

(E)-5-(2-BroMovinyl)pyriMidine-2,4(1H,3H)-dione

Brivudine Impurity ((E)-5-(2-Bromovinyl)uracil )

Brivudine Impurity 4

Brivudine Impurity F

Brivudine Impurity 1 ((E)-5-(2-Bromovinyl)uracil)

BrivudineImpurity1-5-uracil)

5-((E)-2-bromovinyl)pyrimidine

Brovudine 8

Uracil Impurity 13

(<i>E</i>)-5-(2-Bromovinyl)uracil

69304-49-0

C6H6BrN2O2

Pyrimidines

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyrimidines

PyrimidinesHeterocyclic Building Blocks

Building Blocks

C6 to C8

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks