Methyllithium
- Product Name
- Methyllithium
- CAS No.
- 917-54-4
- Chemical Name
- Methyllithium
- Synonyms
- MELI;LITHIUM METHANIDE;Methyllithium solution;Methyllithium lithium bromide complex solution;Lowhalide;1-2MinEther;methyl-lithiu;METHYLLITHIUM;Methy-Lithium;LITHIUM METHYL
- CBNumber
- CB7234211
- Molecular Formula
- CH3Li
- Formula Weight
- 21.98
- MOL File
- 917-54-4.mol
Methyllithium Property
- Melting point:
- 70-71℃
- Boiling point:
- 88℃
- Density
- 0.85 g/mL at 20 °C
- vapor density
- 3 (vs air)
- Flash point:
- 5 °F
- storage temp.
- 2-8°C
- form
- Solution
- Specific Gravity
- 0.83
- color
- Colorless to yellow
- Water Solubility
- Reacts with water.
- Sensitive
- Air & Moisture Sensitive
- Hydrolytic Sensitivity
- 9: reacts extremely rapidly with atmospheric moisture - may be pyrophoric - glove box or sealed system required
- BRN
- 3587162
- Exposure limits
- ACGIH: TWA 400 ppm; STEL 500 ppm
OSHA: TWA 400 ppm(1200 mg/m3)
NIOSH: IDLH 1900 ppm - CAS DataBase Reference
- 917-54-4(CAS DataBase Reference)
- EPA Substance Registry System
- Lithium, methyl- (917-54-4)
Safety
- Hazard Codes
- F+,C,N,F,Xn,Xi
- Risk Statements
- 12-15-17-22-34-66-67-65-51/53-11-36/37/38-36/38-19-40-36/37-37-14/15
- Safety Statements
- 16-26-36/37/39-45-43-30-60-62-61-36/37
- RIDADR
- UN 3399 4.3/PG 1
- WGK Germany
- 2
- F
- 10
- TSCA
- Yes
- HazardClass
- 4.3
- PackingGroup
- I
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H250Catches fire spontaneously if exposed to air
H252Self-heating in large quantities; may catch fire
H260In contact with water releases flammable gases which may ignite spontaneously
H302Harmful if swallowed
H303May be harmfulif swallowed
H304May be fatal if swallowed and enters airways
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
H336May cause drowsiness or dizziness
H401Toxic to aquatic life
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P222Do not allow contact with air.
P223Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P231+P232Handle under inert gas. Protect from moisture.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P309IF exposed or if you feel unwell:
P310Immediately call a POISON CENTER or doctor/physician.
P370+P378In case of fire: Use … for extinction.
P402+P404Store in a dry place. Store in a closed container.
P405Store locked up.
P422Store contents under …
N-Bromosuccinimide Price
- Product number
- 197343
- Product name
- Methyllithium solution
- Purity
- 1.6M in diethyl ether
- Packaging
- 1l
- Price
- $309
- Updated
- 2024/03/01
- Product number
- 186201
- Product name
- Methyllithium lithium bromide complex solution
- Purity
- 1.5?M in diethyl ether
- Packaging
- 100mL
- Price
- $97.3
- Updated
- 2024/03/01
- Product number
- 186201
- Product name
- Methyllithium lithium bromide complex solution
- Purity
- 1.5?M in diethyl ether
- Packaging
- 4x25ml
- Price
- $125
- Updated
- 2024/03/01
- Product number
- 186201
- Product name
- Methyllithium lithium bromide complex solution
- Purity
- 1.5?M in diethyl ether
- Packaging
- 800mL
- Price
- $576
- Updated
- 2024/03/01
- Product number
- 186201
- Product name
- Methyllithium lithium bromide complex solution
- Purity
- 1.5?M in diethyl ether
- Packaging
- 1L
- Price
- $620
- Updated
- 2024/03/01
Methyllithium Chemical Properties,Usage,Production
Chemical Properties
Methyllithium is a colorless to yellowish solution, It is insoluble in hydrocarbon solvents although propyllithium and the higher homologues are miscible in hydrocarbons. Methyllithium is soluble in diethyl ether to about 6% by weight at room temperature (with or without lithium bromide) and is a little less soluble in tetrahydrofuran. Cooling of these solutions produces clear, colorless crystals of methyllithium etherate. Methyllithium is stable to about 200°C, at which temperature it disproportionates to dilithiomethane and methane.
Uses
There are no significant industrial uses of methyllithium, but it is widely used in the laboratory in Grignard type reactions.
Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile.
Uses
Methyllithium lithium bromide complex solution (MeLi.LiBr) can be used as a methylating agent for the α-methylation of alkoxyaryl ketones.
Definition
ChEBI: Methyllithium is an alkyllithium compound and a one-carbon compound.
Preparation
Methyllithium is produced industrially by the reaction of methyl chloride or methyl bromide with lithium metal dispersion in diethyl ether. The reaction with methyl chloride yields a solution of methyllithium and a precipitate of lithium chloride which may be readily separated. When methyl bromide is used, the lithium bromide byproduct remains in solution and complexes with the methyllithium. This reduces the reactivity of the methyllithium and, in certain cases, affects its usefulness. On the other hand, the less reactive complex is more stable in diethyl ether. Methyllithium produced from methyl chloride contains only about 0.3 % lithium chloride in a 5 % solution in diethyl ether. It is more reactive than the lithium bromide complex, but decomposes at the rate of 1 % of the contained methyllithium per year (that is 5.00 % solution goes to 4.95 %) at room temperature. The decomposition by ether cleavage results in methane and ethylene formation which increases the pressure in the container on long storage. Methyllithium can be prepared easily in tetrahydrofuran but it has a half-life of only about 2 days at room temperature due to solvent cleavage.
Application
Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of (?)-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydroisoquinoline in the presence of (?)-sparteine as a chiral ligand.
Hazard
Flammable, dangerous fire and explosionrisk, self-ignites in air.
Methyllithium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyllithium manufacturers
- Product
- Methyllithium 917-54-4
- Price
- US $9.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2021-11-08
- Product
- Methyllithium 917-54-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-17
- Product
- METHYLLITHIUM 917-54-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1
- Release date
- 2018-08-06