ChemicalBook > CAS DataBase List > KEMPTIDE

KEMPTIDE

Product Name
KEMPTIDE
CAS No.
65189-71-1
Chemical Name
KEMPTIDE
Synonyms
LRRASLG;KEMPTIDE;Nsc332190;KEMPTIDE ACETATE;KEMPTIDE [LRRASLG];KEMPTIDE ACETATE SALT;PHOSPHATE ACCEPTOR PEPTIDE;LEU-ARG-ARG-ALA-SER-LEU-GLY;LEU-ARG-ARG-ALA-SER-LEU-GLY-OH;Polypeptide (boehringer) 600925
CBNumber
CB7234741
Molecular Formula
C32H61N13O9
Formula Weight
771.91
MOL File
65189-71-1.mol
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KEMPTIDE Property

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: 20 mg/mL
form 
powder
pka
3.32±0.10(Predicted)
color 
white
Water Solubility 
Soluble in water (20 mg/ml).
Sequence
H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
3-10
HS Code 
35079090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J60591
Product name
Kemptide
Packaging
5mg
Price
$150
Updated
2023/06/20
Alfa Aesar
Product number
J60591
Product name
Kemptide
Packaging
1mg
Price
$44
Updated
2021/12/16
Cayman Chemical
Product number
15555
Product name
Kemptide
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
15555
Product name
Kemptide
Purity
≥95%
Packaging
5mg
Price
$140
Updated
2024/03/01
Cayman Chemical
Product number
15555
Product name
Kemptide
Purity
≥95%
Packaging
10mg
Price
$257
Updated
2024/03/01
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KEMPTIDE Chemical Properties,Usage,Production

Uses

Kemptide, phosphate acceptor, is shown to be a basic serine-containing heptapeptide corresponding to a sequence from pig liver pyruvate kinase. This synthetic peptide is a substrate of PKA (cyclic AMP-dependent protein kinase) and is phosphorylated and activated after microinjection into Xenopus oocytes. Exposure of Kemptide to insulin has demonstrated an increase in activation of this agent, which can be inhibited by the catalytic subunit of phosphatase 2A.

Biological Activity

kemptide is a synthetic heptapeptide that acts as a substrate for camp-dependent protein kinase (pk) [1].cyclic amp-dependent protein kinase is the sole intracellular acceptor for cyclic amp in all cell types. protein phosphorylation by different types of protein kinase (pk) activities comprises a form of protein modification that plays an important role in the regulation of numerous biological processes [1][2].kemptide is a novel synthetic heptapeptide phosphate acceptor that acts as a substrate for camp-dependent protein kinase. kemptide had all the properties of a cytophilic substrate and could preserving cell membrane intactness when added to cultured cells. in the presence of extracellular atp and camp, different types of intact cells catalyzed the phosphorylation of kemptide with km values of 3-4 μm. kemptide phosphorylation was influenced by pki, the inhibitory protein specific for camp-pk [1]. kemptide was usually used as a substrate for detection of activities of soluble a-kinase isolated from guinea-pig lung parenchyma and from bovine tracheal smooth muscle [2][3].

References

[1]. kübler d, pyerin w, bill o, et al. evidence for ecto-protein kinase activity that phosphorylates kemptide in a cyclic amp-dependent mode. j biol chem. 1989 aug 25;264(24):14549-55.
[2]. giembycz ma, diamond j. evaluation of kemptide, a synthetic serine-containing heptapeptide, as a phosphate acceptor for the estimation of cyclic amp-dependent protein kinase activity in respiratory tissues. biochem pharmacol. 1990 jan 15;39(2):271-83.
[3]. langlands jm, rodger iw. determination of soluble camp-dependent protein kinase activity in guinea-pig tracheal smooth muscle. preferential use of kemptide as a phosphorylating substrate. biochem pharmacol. 1990 apr 15;39(8):1365-74.

KEMPTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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KEMPTIDE Suppliers

China 77 France 1 Germany 2 Switzerland 2 United Kingdom 1 United States 25 Global 108
BOC Sciences
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View Lastest Price from KEMPTIDE manufacturers

Career Henan Chemical Co
Product
KEMPTIDE 65189-71-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-18

65189-71-1, KEMPTIDERelated Search:

KEMPTIDE, SYNTHETIC, >97% PURITY KEMPTIDE [LRRWSLG], [TRP4],[TRP4]-KEMPTIDE KEMPTIDE KEMPTIDE [LRRASLG], BIOTINYLATED-LC KEMPTIDE, 5-FAM LABELED,KEMPTIDE [LRRASLG], 5-FAM LABELED KEMPTIDE, 5-TMR LABELED,KEMPTIDE [LRRASLG], 5-TMR LABELED [PSER5]-KEMPTIDE, BIOTINYLATED-LC [PSER5]-KEMPTIDE, 5-TMR LABELED CYS-KEMPTIDE KEMPTIDE [LRRASLG], BIOTINYLATED [PSER5]-KEMPTIDE, BIOTINYLATED [PSER5]-KEMPTIDE KEMPTIDE [LRRAALG], NEGATIVE CONTROL KEMPTIDE, AMIDE Kemptide [LRRASLG], Hilytefluor488 labeled Kemptide (Phosphate Acceptor Peptide) KEMPTIDE [LRRASVA], [VAL6, ALA7],(VAL6,ALA7)-KEMPTIDE KEMPTIDE [LKRA-PT-LG], [LYS2, PT5]

  • L-Leucyl-L-arginyl-L-arginyl-L-alanyl-L-seryl-L-leucylglycine
  • Glycine,L-leucyl-L-arginyl-L-arginyl-L-alanyl-L-seryl-L-leucyl-
  • Kemptide acetate salt, ≥95% (HPLC)
  • LRRASLG
  • LEU-ARG-ARG-ALA-SER-LEU-GLY
  • LEU-ARG-ARG-ALA-SER-LEU-GLY-OH
  • KEMPTIDE [LRRASLG]
  • KEMPTIDE ACETATE SALT
  • KEMPTIDE
  • H-LEU-ARG-ARG-ALA-SER-LEU-GLY-OH
  • ARG-ARG-LYS-ALA-SER-GLY-PRO-PRO-VAL
  • PHOSPHATE ACCEPTOR PEPTIDE
  • PHOSPHATE ACCEPTOR PEPTIDE ACETATE SALT
  • KEMPTIDE ACETATE
  • H-Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val-OH
  • Nsc332190
  • Polypeptide (boehringer) 600925
  • 65189-71-1
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Kinase/Phosphatase Biology
  • Protein Kinase A (PKA)
  • Serine/Threonine Kinase Substrates
  • Peptide