1-Amino-2,4-dibromonaphthalene
- Product Name
- 1-Amino-2,4-dibromonaphthalene
- CAS No.
- 20191-76-8
- Chemical Name
- 1-Amino-2,4-dibromonaphthalene
- Synonyms
- 2,4-dibromonaphthalen-1-amine;2,4-Dibromo-1-naphtylamine;2,4-Dibromo-1-naphthylamine;2,4-Dibromo-1-naphthalenamine;2,4-Dibromonaphthalene-1-amine;1-Amino-2,4-dibromonaphthalene;2,4-dibromonaphthalen-1-amine1;1-Naphthalenamine, 2,4-dibromo-
- CBNumber
- CB72408632
- Molecular Formula
- C10H7Br2N
- Formula Weight
- 300.98
- MOL File
- 20191-76-8.mol
1-Amino-2,4-dibromonaphthalene Property
- Melting point:
- 115 °C
- Boiling point:
- 369.7±27.0 °C(Predicted)
- Density
- 1.902±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -0.22±0.10(Predicted)
- Appearance
- Yellow to brown Solid
Safety
- HS Code
- 2921599090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S860042
- Product name
- 2,4-DIBROMO-1-NAPHTHYLAMINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S860042
- Product name
- 2,4-DIBROMO-1-NAPHTHYLAMINE
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $106
- Updated
- 2023/06/20
- Product number
- D426276
- Product name
- 2,4-Dibromonaphthalen-1-amine
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 102786
- Product name
- 2,4-Dibromonaphthalen-1-amine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $544
- Updated
- 2021/12/16
- Product number
- 3630-9-06
- Product name
- 2,4-Dibromonaphthalen-1-amine
- Packaging
- 1g
- Price
- $637
- Updated
- 2021/12/16
1-Amino-2,4-dibromonaphthalene Chemical Properties,Usage,Production
Uses
2,4-Dibromonaphthalen-1-amine is used as a reactant in the preparation of pyrazoles as inhibitors of macrophage migration inhibitory factor.
Synthesis
134-32-7
20191-76-8
General procedure for the synthesis of 2,4-dibromo-1-aminonaphthalene from 1-naphthylamine: a mixture of 1-naphthylamine (286 mg, 2 mmol), potassium bromide (309 mg, 2.6 mmol), acetic acid (9 mL), water (1 mL), and dichloromethane (5 mL) was added sequentially to a three-necked flask equipped with a condenser and a thermometer. ZnAl-BrO3-LDHs (3.6 g, 3.6 mmol) was slowly added over 15 min in a thermostatically heated magnetic stirring water bath. The reaction temperature was controlled to be 25 °C for 5 h. The reaction was carried out at a constant temperature with magnetic stirring. After completion of the reaction, the reaction mixture was washed with sodium sulfite solution. It was subsequently extracted with dichloromethane (3 × 10 mL), the organic phases were combined and silica gel (200-300 mesh) was added to the organic phase. The organic solvent was removed by distillation under reduced pressure and the residue was purified by column chromatography (eluent was petroleum ether: ethyl acetate = 13:1) to afford 566 mg of the target product 2,4-dibromo-1-aminonaphthalene as a reddish brown solid in 94% yield.
References
[1] Canadian Journal of Chemistry, 2005, vol. 83, # 2, p. 146 - 149
[2] Patent: CN107417543, 2017, A. Location in patent: Paragraph 0056-0058; 0062
[3] Patent: WO2017/201161, 2017, A1. Location in patent: Paragraph 0215; 0246
[4] Synthetic Communications, 2004, vol. 34, # 24, p. 4597 - 4604
[5] ChemMedChem, 2018, vol. 13, # 11, p. 1092 - 1097
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View Lastest Price from 1-Amino-2,4-dibromonaphthalene manufacturers
- Product
- 2,4-Dibromonaphthalen-1-amine 20191-76-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-18
- Product
- 1-Amino-2,4-dibromonaphthalene 20191-76-8
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 Ton
- Release date
- 2023-09-19
- Product
- 1-Amino-2,4-dibromonaphthalene 20191-76-8
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 30000 Kg
- Release date
- 2023-11-02