1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1029716-44-6
Chemical Name: 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: (1-(1-ethoxyethyl)-1H-pyrazol-4-yl)boronic acid;1-(1-Ethoxyethyl)pyrazole-4-boronic Acid Pinacol Ester;1-(1-Ethoxyethyl)-1H-pyrazole-4-boronic acid pinacol ester;1-(1-ethoxyethyl)-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;Baricitinib-002;-yl)-1H-pyrazole;1-(1-Ethoxyethyl);Baritinib impurity 10;1-(1-ethoxyethyl)-4-(4;Lenvatinib Impurity 146
CBNumber: CB72445754
Molecular Formula: C13H23BN2O3
Formula Weight: 266.14
MOL File: 1029716-44-6.mol

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1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:: 353.3±22.0 °C(Predicted)
Density: 1.06
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 1.55±0.10(Predicted)
form: solid
color: White
InChI: InChI=1S/C13H23BN2O3/c1-7-17-10(2)16-9-11(8-15-16)14-18-12(3,4)13(5,6)19-14/h8-10H,7H2,1-6H3
InChIKey: IZKVGEWCELXYRI-UHFFFAOYSA-N
SMILES: N1(C(OCC)C)C=C(B2OC(C)(C)C(C)(C)O2)C=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE001296
Product name: 1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: Aldrich
Packaging: 1g
Price: $1300
Updated: 2025/07/31

TRC

Product number: E892028
Product name: 1-(1-Ethoxyethyl)-1H-pyrazole-4-boronicAcidPinacolEster
Packaging: 500mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J97125
Product name: 1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 25g
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-M1565
Product name: 1H-Pyrazole,1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
Purity: >98.0%
Packaging: 10g
Price: $19
Updated: 2021/12/16

Synthonix

Product number: E9945
Product name: 1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Purity: 90+%
Packaging: 10g
Price: $30
Updated: 2021/12/16

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1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Uses

1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is an important pharmaceutical intermediate of Baricitinib.

Synthesis

1024120-52-2

1195-66-0

1029716-44-6

Step 3: To a pre-oven-dried vial at room temperature was added a lithium isopropylmagnesium chloride solution (1.0 M, dissolved in THF, 6.32 mL, 8.22 mmol). Subsequently, 4-bromo-1-(1-ethoxyethyl)-1H-pyrazole (1.00 g, 4.56 mmol) was slowly added dropwise to this solution. The reaction mixture was stirred continuously at room temperature for 16 hours. Upon completion of the reaction, the mixture was cooled to -20 °C and 2-methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.73 g, 10.95 mmol) was added via syringe. Subsequently, the reaction mixture was slowly warmed up to room temperature. After continued stirring at room temperature for 2 h, the reaction was quenched by the addition of saturated aqueous ammonium chloride solution (15 mL), at which time the formation of a white precipitate was observed. The mixture was diluted with additional water (20 mL) and extracted with hexane (140 mL each time, 2 times). The organic phases were combined and washed sequentially with saturated aqueous sodium bicarbonate and brine, then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated to give 1.20 g (99% yield) of the target product 1-(1-ethoxyethyl)-4-pyrazoleboronic acid pinacol ester as a colorless oil.

References

[1] Patent: WO2014/74661, 2014, A1. Location in patent: Paragraph 00251
[2] Patent: WO2015/69310, 2015, A1. Location in patent: Paragraph 00175
[3] Patent: TWI582077, 2017, B. Location in patent: Page/Page column 82
[4] Organic Letters, 2009, vol. 11, # 9, p. 1999 - 2002
[5] Patent: US2010/190981, 2010, A1. Location in patent: Page/Page column 105

1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

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View Lastest Price from 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1029716-44-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-28

Handan City Zechi trading Co., LTD

Product: 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1029716-44-6
Price: US $1.00/g
Min. Order: 100g
Purity: 99
Supply Ability: 10000
Release date: 2025-08-12

Wuhan Biocar Pharmacy CO.,Ltd.

Product: 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1029716-44-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 500kg
Release date: 2025-03-20

1029716-44-6, 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleRelated Search:

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1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

1H-Pyrazole, 1-(1-ethoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

1-(1-ethoxyethyl)-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)boronic acid

1-(1-ethoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyrazole

1-(1-Ethoxyethyl)-1H-pyrazole-4-boronic acid pinacol ester

1-(1-EthoxyEthyl)-Pyrazole- 4-Boronic acid Pinacolate

1-(1-Ethoxyethyl)

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1-(1-Ethoxyethyl)pyrazole-4-boronic Acid Pinacol Ester

1-(Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Baricitinib-002

1-(1-ethoxyethyl)-4-(4

1-(1-ethoxyethyl)-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)

seven β- Amino-3 - [4 - (1-methyl-4-pyridinium) - 2-thiazolyl] - 3-cephem-4-carboxylic acid · dihydrochloride

1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-...

Benzene,1,6-bis(decyloxy)-

(1- (1-ethoxyethyl) -4-pyrazole borate Pinacol ester)

Baricitinib intermediate 1

1-(1-ethoxyethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole

-yl)-1H-pyrazole

1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl

Lenvatinib Impurity 146

Baritinib impurity 10

Baricitinib Impurity 60

1-(1-Ethoxyethyl)-4-pyrazoleboronicacidpinacolester

1-(1-Ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [E9945]

1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-y)-1H-pyrazole

1029716-44-6

C13H23BN2O3

1029716-44-6