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CDK2 INHIBITOR II

Product Name
CDK2 INHIBITOR II
CAS No.
222035-13-4
Chemical Name
CDK2 INHIBITOR II
Synonyms
SC 221409;COMPOUND 3;CDK2 INHIBITOR II;CDK2-IN-3 (compound 3);SC 221409, Cdk2 inhibitor;4-(2-(5-Bromo-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide;4-[2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]-benzenesulfonamide;Benzenesulfonamide, 4-[2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]-
CBNumber
CB7244623
Molecular Formula
C14H11BrN4O3S
Formula Weight
395.23
MOL File
222035-13-4.mol
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CDK2 INHIBITOR II Property

Melting point:
>272°C (dec.)
Density 
1.85±0.1 g/cm3(Predicted)
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
8.81±0.20(Predicted)
color 
Light Orange to Orange
InChI
InChI=1S/C14H11BrN4O3S/c15-8-1-6-12-11(7-8)13(14(20)17-12)19-18-9-2-4-10(5-3-9)23(16,21)22/h1-7,18H,(H2,16,21,22)(H,17,19,20)
InChIKey
ODZNNZYRBRRREX-UHFFFAOYSA-N
SMILES
C1(S(N)(=O)=O)=CC=C(NN=C2C3=C(NC2=O)C=CC(Br)=C3)C=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15154
Product name
Cdk2 Inhibitor II
Purity
≥95%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15154
Product name
Cdk2 Inhibitor II
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
15154
Product name
Cdk2 Inhibitor II
Purity
≥95%
Packaging
5mg
Price
$166
Updated
2024/03/01
TRC
Product number
C228120
Product name
CDK2inhibitorII
Packaging
10mg
Price
$120
Updated
2021/12/16
AK Scientific
Product number
6150CK
Product name
Cdk2InhibitorII
Packaging
5mg
Price
$282
Updated
2021/12/16
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CDK2 INHIBITOR II Chemical Properties,Usage,Production

Description

The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM). It is cell permeable, reversible, and ATP-competitive.

Uses

CDK2 inhibitor II, is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2.

in vivo

CDK2-IN-3 (2.5-250 μg, topical application, once daily, for 1 week) significantly reduces the incidence of alopecia in neonatal rat model induced by the combination of cyclophosphamide (HY-17420) and doxorubicin (HY-15142A)[1].

Animal Model:Cyclophosphamide (HY-17420)-Doxorubicin (HY-15142A) combination chemotherapy-induced alopecia neonatal Sprague-Dawley rat model (13 days)
Dosage:2.5-250 μg
Administration:Topical application, once daily for 1 week
Result:Effectively prevented alopecia in 50% of rats and provided partial protection in an additional 20%.

IC 50

CDK2: 60 nM (IC50)

References

[1] FUNK J. Cell Cycle Checkpoint Genes and Cancer[C]. 2006: 0. DOI: 10.1038/npg.els.0006046
[2] STEPHEN T. DAVIS, JR. Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors[J]. Science, 2001, 291 5501. DOI: 10.1126/science.291.5501.134

CDK2 INHIBITOR II Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK2 INHIBITOR II Suppliers

China 29 United Kingdom 1 United States 8 Global 38
Suzhou Su Taike Biological Reagent Co., Ltd.
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J & K SCIENTIFIC LTD.
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jkinfo@jkchemical.com
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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222035-13-4, CDK2 INHIBITOR IIRelated Search:


  • CDK2 INHIBITOR II
  • COMPOUND 3
  • SC 221409
  • Benzenesulfonamide, 4-[2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]-
  • CDK2-IN-3 (compound 3)
  • 4-(2-(5-Bromo-2-oxoindolin-3-ylidene)hydrazinyl)benzenesulfonamide
  • 4-[2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazinyl]-benzenesulfonamide
  • SC 221409, Cdk2 inhibitor
  • 222035-13-4
  • Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals