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TOFIMILAST

Product Name
TOFIMILAST
CAS No.
185954-27-2
Chemical Name
TOFIMILAST
Synonyms
366;CP-325;CP 325;CP325366;CP-325366;CP 325366;TOFIMILAST;5H-Pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a]pyridine, 9-cyclopentyl-7-ethyl-6,9-dihydro-3-(2-thienyl)-
CBNumber
CB72446544
Molecular Formula
C18H21N5S
Formula Weight
339.46
MOL File
185954-27-2.mol
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TOFIMILAST Property

Melting point:
125-126 °C(Solv: ethyl ether (60-29-7))
Boiling point:
589.4±60.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
pka
1.76±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0025146
Product name
TOFIMILAST
Purity
95.00%
Packaging
5MG
Price
$495.79
Updated
2021/12/16
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TOFIMILAST Chemical Properties,Usage,Production

Uses

Tofimilast is an inhibitor of Phosphodiesterase 4 (PDE4) with an IC50 of 0.14 μM. Tofimilast exerts its anti-inflammatory effects by inhibiting the activity of PDE4, thereby increasing intracellular levels of cAMP[1].

Definition

ChEBI: Tofimilast is a triazolopyridine.

IC 50

PDE4: 0.14 μM (IC50)

References

[1] Duplantier AJ, et al. SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. J Med Chem. 2007 Jan 25;50(2):344-9. DOI:10.1021/jm060904g

TOFIMILAST Preparation Products And Raw materials

Raw materials

Preparation Products

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TOFIMILAST Suppliers

CHINA 8 United States 2 Global 10
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
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Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2742
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58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
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TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29257
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58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58

185954-27-2, TOFIMILASTRelated Search:

2-(1H-PYRAZOL-4-YL)-ETHYLAMINE 2-(1-ETHYL-3,5-DIMETHYL-1H-PYRAZOL-4-YL)ETHYLAMINE 4-ETHYL-3,5-DIMETHYL-4H-1,2,4-TRIAZOLE 2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine TOFIMILAST

  • TOFIMILAST
  • 366
  • CP 325
  • CP 325366
  • CP-325
  • CP325366
  • CP-325366
  • 5H-Pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a]pyridine, 9-cyclopentyl-7-ethyl-6,9-dihydro-3-(2-thienyl)-
  • 185954-27-2