AWD-12-281

Product Name: AWD-12-281
CAS No.: 257892-33-4
Chemical Name: AWD-12-281
Synonyms: GSK-842470;GSK 842470;AWD-12-281;AWD 12 281,AWD 12281;N-(3,5-Dichloro-4-pyridyl)-2-[1-(4-fluorobenzyl)-5-hydroxy-3-indolyl]-2-oxoacetamide;N-(3,5-Dichloro-pyridin-4-yl)-2-[1-(4-fluoro-benzyl)-5-hydroxy-1H-indol-3-yl]-2-oxo-acetamide;1H-Indole-3-acetamide, N-(3,5-dichloro-4-pyridinyl)-1-[(4-fluorophenyl)methyl]-5-hydroxy-α-oxo-
CBNumber: CB72448311
Molecular Formula: C22H14Cl2FN3O3
Formula Weight: 458.27
MOL File: 257892-33-4.mol

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AWD-12-281 Property

Density: 1.49±0.1 g/cm3(Predicted)
pka: 7.34±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

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AWD-12-281 Chemical Properties,Usage,Production

Uses

AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 9.7 nM). AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis[1][2].

IC 50

PDE4: 9.7 nM (IC₅₀)

References

[1] Wolfgang B?umer, et al. AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis. J Pharm Pharmacol. 2003 Aug;55(8):1107-14. DOI:10.1211/0022357021585
[2] Regina Draheim, et al. Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations. J Pharmacol Exp Ther. 2004 Feb;308(2):555-63. DOI:10.1124/jpet.103.059097

AWD-12-281 Preparation Products And Raw materials

Raw materials

Preparation Products

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AWD-12-281 Suppliers

China 6 United States 3 Global 9

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257892-33-4, AWD-12-281Related Search:

2-(1H-INDOL-3-YL)-2-OXO-ETHYLAMINE HCL (3-(2-AMINOETHYL)-1-METHYLINDOLE) 2HCL AWD-12-281 (3,5-DICHLORO-PYRIDIN-4-YL)METHYLAMINE 1-(4-FLUORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE

AWD-12-281

N-(3,5-Dichloro-pyridin-4-yl)-2-[1-(4-fluoro-benzyl)-5-hydroxy-1H-indol-3-yl]-2-oxo-acetamide

1H-Indole-3-acetamide, N-(3,5-dichloro-4-pyridinyl)-1-[(4-fluorophenyl)methyl]-5-hydroxy-α-oxo-

GSK 842470

GSK-842470

AWD 12 281,AWD 12281

N-(3,5-Dichloro-4-pyridyl)-2-[1-(4-fluorobenzyl)-5-hydroxy-3-indolyl]-2-oxoacetamide

257892-33-4