7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

Product Name: 7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
CAS No.: 105807-83-8
Chemical Name: 7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
Synonyms: 7-Amino-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one;7-amino-2,2-dimethyl-2H-1,4-benzoxazin-3(4H)-one;7-Amino-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H);2H-1,4-Benzoxazin-3(4H)-one, 7-amino-2,2-dimethyl-;7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;7-amino-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one
CBNumber: CB72455696
Molecular Formula: C10H12N2O2
Formula Weight: 192.21
MOL File: 105807-83-8.mol

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7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Light yellow to brown Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FA127082
Product name: 7-Amino-2,2-dimethyl-2H-1,4-benzoxazin-3(4H)-one
Packaging: 100mg
Price: $58
Updated: 2021/12/16

Apolloscientific

Product number: OR321360
Product name: 7-Amino-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one
Packaging: 1g
Price: $88
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA127082
Product name: 7-Amino-2,2-dimethyl-2H-1,4-benzoxazin-3(4H)-one
Packaging: 250mg
Price: $115
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA127082
Product name: 7-Amino-2,2-dimethyl-2H-1,4-benzoxazin-3(4H)-one
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 072693
Product name: 7-Amino-2,2-dimethyl-2H-benzo-[b][1,4]oxazin-3(4H)-one
Purity: 95+%
Packaging: 250mg
Price: $278
Updated: 2021/12/16

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7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE Chemical Properties,Usage,Production

Synthesis

85160-83-4

105807-83-8

General procedure for the synthesis of 7-amino-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one from 2,2-dimethyl-7-nitro-2H-benzo[b][1,4]oxazine-3(4H)-one: 100 mM of mixed solvent (EtOH:H2O = 3:1) was added to the reaction flask and stirred at room temperature. 30 mM of 2,2-dimethyl-7-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one, 10 mM of ammonium chloride and 30 mM of iron powder were added sequentially. The reaction mixture was heated to 90 °C and refluxed for 1-2 hours. The progress of the reaction was monitored by TLC. After completion of the reaction, the excess iron powder was removed by filtration while hot. After cooling, the solvent was removed by distillation under reduced pressure. The pH of the residual solids was adjusted to 10 with aqueous potassium carbonate to induce precipitation of the solids, followed by filtration. The filter cake was washed with cooling water and dried under vacuum to give a pure intermediate of 4.23 g yellow powder in 73.4% yield. The intermediate did not require further purification and could be used directly in the subsequent reaction.

References

[1] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 3, p. 262 - 267
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985, vol. 24, p. 1263 - 1267
[3] Patent: CN107459494, 2017, A. Location in patent: Paragraph 0138; 0143-0145
[4] Molecular Diversity, 2017, vol. 21, # 1, p. 125 - 136
[5] Patent: EP2883870, 2015, A1. Location in patent: Paragraph 0075; 0076

7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE Suppliers

China 44 Germany 1 India 1 United Kingdom 1 United States 14 Global 61

Shanghai Boc Chemical Co.,Ltd

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105807-83-8, 7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONERelated Search:

2,2-DIMETHYL-6-NITRO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-ONE 2,2-DIMETHYL-7-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE ETHYL 2-METHYL-6-NITRO-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE 2-METHYL-7-NITRO-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLIC ACID 2-METHYL-6-NITRO-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLIC ACID ETHYL 2-METHYL-7-NITRO-3-OXO-3,4-DIHYDRO-2H-1,4-BENZOXAZINE-2-CARBOXYLATE 6-AMINO-2,2-DIMETHYL-4-(2-PHENYL-CYCLOPROPANECARBONYL)-4H-BENZO[1,4]OXAZIN-3-ONE 7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

7-amino-2,2-dimethyl-2H-1,4-benzoxazin-3(4H)-one

7-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

7-Amino-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)

7-Amino-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one

7-amino-2,2-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-3-one

2H-1,4-Benzoxazin-3(4H)-one, 7-amino-2,2-dimethyl-

105807-83-8