5-HYDROXY-1-BENZOFURAN-2-CARBOXYLIC ACID
- Product Name
- 5-HYDROXY-1-BENZOFURAN-2-CARBOXYLIC ACID
- CAS No.
- 56172-36-2
- Chemical Name
- 5-HYDROXY-1-BENZOFURAN-2-CARBOXYLIC ACID
- Synonyms
- 5-hydroxy-2-Benzofurancarboxylic acid;5-HYDROXY-BENZOFURAN-2-CARBOXYLIC ACID;2-Benzofurancarboxylic acid, 5-hydroxy-;5-HYDROXY-1-BENZOFURAN-2-CARBOXYLIC ACID
- CBNumber
- CB72455898
- Molecular Formula
- C9H6O4
- Formula Weight
- 178.14
- MOL File
- 56172-36-2.mol
5-HYDROXY-1-BENZOFURAN-2-CARBOXYLIC ACID Property
- Melting point:
- 252-254 °C
- Boiling point:
- 396.4±22.0 °C(Predicted)
- Density
- 1.518±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.06±0.30(Predicted)
N-Bromosuccinimide Price
- Product number
- H875465
- Product name
- 5-Hydroxybenzofuran-2-carboxylicacid
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- H875465
- Product name
- 5-Hydroxybenzofuran-2-carboxylicacid
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 8211AB
- Product name
- 5-Hydroxybenzofuran-2-carboxylicacid
- Packaging
- 1g
- Price
- $462
- Updated
- 2021/12/16
- Product number
- CHM0390776
- Product name
- 5-HYDROXYBENZOFURAN-2-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.21
- Updated
- 2021/12/16
- Product number
- A173575
- Product name
- 5-Hydroxybenzofuran-2-carboxylicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $500
- Updated
- 2021/12/16
5-HYDROXY-1-BENZOFURAN-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
10242-08-7
56172-36-2
Step 1: Preparation of 5-hydroxybenzofuran-2-carboxylic acid. 5-Methoxybenzofuran-2-carboxylic acid (1.0 g, 5.2 mmol) was dissolved in anhydrous dichloromethane (25 ml) and the solution was cooled to -78°C. A 1 M solution of boron tribromide dichloromethane (15.6 ml) was added slowly and dropwise under nitrogen protection. The reaction mixture was gradually warmed to room temperature and stirred continuously at this temperature for 4 hours. Upon completion of the reaction, the reaction was quenched with aqueous ammonium chloride solution (20 ml) and subsequently extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. After treatment, 0.9 g (100% yield) of the crude product of 5-hydroxybenzofuran-2-carboxylic acid was obtained.1H NMR (CD3OD) δ = 6.84 (dd, 1H), 6.95 (d, 1H), 7.17 (s, 1H), 7.32 (d, 1H).
References
[1] Patent: US2005/26969, 2005, A1. Location in patent: Page/Page column 12
[2] Patent: WO2008/157270, 2008, A1. Location in patent: Page/Page column 74-75
5-HYDROXY-1-BENZOFURAN-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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