TERRESTRIN A
- Product Name
- TERRESTRIN A
- CAS No.
- 858134-23-3
- Chemical Name
- TERRESTRIN A
- Synonyms
- VIALININ A;TERRESTRIN A;NOJUKCRPSUMHQQ-UHFFFAOYSA-N;1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester;Benzeneacetic acid, 1,1'-(4,4'',5',6'-tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) ester
- CBNumber
- CB72456370
- Molecular Formula
- C34H26O8
- Formula Weight
- 562.57
- MOL File
- 858134-23-3.mol
TERRESTRIN A Property
- Melting point:
- 220-223 °C
- Boiling point:
- 846.9±65.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- crystalline solid
- pka
- 7.81±0.15(Predicted)
- color
- Off-white to light brown
N-Bromosuccinimide Price
- Product number
- 10010519
- Product name
- Vialinin A
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $91
- Updated
- 2024/03/01
- Product number
- 10010519
- Product name
- Vialinin A
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $295
- Updated
- 2024/03/01
- Product number
- 10010519
- Product name
- Vialinin A
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 10010519
- Product name
- Vialinin A
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $805
- Updated
- 2021/12/16
- Product number
- 257045
- Product name
- Vialinin A
- Packaging
- 1mg
- Price
- $319
- Updated
- 2021/12/16
TERRESTRIN A Chemical Properties,Usage,Production
Uses
Vialinin A is a Potent Inhibitor of TNF-α production. Vialinin A is a potent antioxidant.
Biological Activity
vialinin a is a potent inhibitor of ubiquitin-specific peptidases with ic50 values of 1.5, 5.9 and 22.3 μm for ubiquitin-specific peptidase 4 (usp4), usp5/isopeptidase t (isot) and uch-l1 deubiquitinating enzyme (dub), respectively [1].ubiquitin-specific peptidases (usps) are a series of proteases that deubiquitinate target proteins. the dynamic modification of a protein with ubiquitin can modify its function, localization and fate in the cell. ubiquitin hydrolase plays an important role in immunology and infection [2].in rbl-2h3 cells, vialinin a inhibited tnf-ɑ production and release and inhibited usp5 enzymatic activity. in usp5 sirna-knockdown rbl-2h3 cells, vialinin a inhibited tnf-ɑ production and release in a dose dependent way. also, the mrna expression of tnf-ɑ was decreased significantly [2]. in rbl-2h3 cells, vialinin a inhibited tnf-ɑ production with ic50 value of 0.09 nm. also, it inhibited the release of interleukin 4, β-hexosaminidase and monocyte chemotactic protein 1, which suggested vialinin a had anti-allergic activities [3].
References
[1]. okada k, ye yq, taniguchi k, et al. vialinin a is a ubiquitin-specific peptidase inhibitor. bioorg med chem lett, 2013, 23(15): 4328-4331.
[2]. yoshioka y, ye yq, okada k, et al. ubiquitin-specific peptidase 5, a target molecule of vialinin a, is a key molecule of tnf-α production in rbl-2h3 cells. plos one, 2013, 8(12): e80931.
[3]. onose j, xie c, ye yq, et al. vialinin a, a novel potent inhibitor of tnf-alpha production from rbl-2h3 cells. biol pharm bull, 2008, 31(5): 831-833.
TERRESTRIN A Preparation Products And Raw materials
Raw materials
Preparation Products
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