TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE

Product Name: TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE
CAS No.: 930785-40-3
Chemical Name: TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE
Synonyms: EOS-62238;1-Oxa-9-Boc-4,9-diazaspiro[5.5]undecane;9-Boc-1-Oxa-4,9-diazaspiro[5.5]undecane;1-Oxa-4,9-diazaspiro[5.5]undecane,N9-BOCprotected;tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecan-9-carboxylate;TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE;tert-butyl1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate 1-;1,1-Dimethylethyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate;tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate - [B13035];1-Oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester
CBNumber: CB72457463
Molecular Formula: C13H24N2O3
Formula Weight: 256.34
MOL File: 930785-40-3.mol

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TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE Property

Boiling point:: 364.2±42.0 °C(Predicted)
Density: 1.11
storage temp.: 2-8°C
pka: 8.82±0.20(Predicted)
form: crystalline powder
color: White
InChI: InChI=1S/C13H24N2O3/c1-12(2,3)18-11(16)15-7-4-13(5-8-15)10-14-6-9-17-13/h14H,4-10H2,1-3H3
InChIKey: FRROFBJYHIEDPS-UHFFFAOYSA-N
SMILES: O1C2(CCN(C(OC(C)(C)C)=O)CC2)CNCC1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories

Product number: 4H51-1-3C
Product name: 9-Boc-1-oxa-4,9-diazaspiro[5.5]undecane
Purity: 97%
Packaging: 250mg
Price: $111
Updated: 2021/12/16

Synthonix

Product number: B13035
Product name: tert-Butyl1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate
Purity: 95+%
Packaging: 1g
Price: $190
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H51-1-3C
Product name: 9-Boc-1-oxa-4,9-diazaspiro[5.5]undecane
Purity: 97%
Packaging: 1g
Price: $234
Updated: 2021/12/16

AK Scientific

Product number: Z5356
Product name: 9-Boc-1-oxa-4,9-diazaspiro[5.5]undecane
Packaging: 1g
Price: $269
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB134944
Product name: tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate
Packaging: 250mg
Price: $370
Updated: 2021/12/16

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TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

1160247-07-3

930785-40-3

The reaction was carried out in 12 batches as follows: borane-dimethyl sulfide complex (10 M, dissolved in dimethyl sulfide, 75 mL, 750 mmol) was slowly added dropwise to a solution of tert-butyl 3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate (50 g, 180 mmol) in tetrahydrofuran (1.5 L). The reaction mixture was heated at reflux for 6 h at 70 °C, followed by stirring for 10 h at 25 °C. Upon completion of the reaction, the reaction was quenched with methanol (500 mL) and stirring was continued at 25 °C for 30 min, after which it was concentrated under reduced pressure. The resulting white solid was dissolved in methanol (1 L), N,N'-dimethylethane-1,2-diamine (65 g, 740 mmol) was added, and heated at reflux for 16 hours at 70 °C. Twelve batches of the reaction mixture were combined and concentrated in vacuum to give a pale yellow oil. This oily substance was dissolved in dichloromethane (4 L), washed with aqueous ammonium chloride (4 x 2 L), dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was ground with petroleum ether (500 mL) at 25°C for 30 min to give a white solid product (304 g). The milled filtrate was concentrated under vacuum and the residue was ground with petroleum ether (200 mL) at 25 °C for 36 h to give additional white solid product (135 g). Total yield: 439 g, 1.71 mol, 77%. lcms m/z 257.2 [M + H]+. 1H NMR (400 MHz, CDCl3) δ 3.85-3.59 (m, 4H), 3.14 (br dd, J = 11,11 Hz, 2H), 2.84 (dd, J = 4.9,4.6 Hz, 2H), 2.68 (s , 2H), 2.02-1.84 (br m, 2H), 1.47-1.33 (m, 2H), 1.45 (s, 9H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7458 - 7461
[2] Patent: WO2017/21805, 2017, A1. Location in patent: Page/Page column 83; 85
[3] Patent: US2018/208608, 2018, A1. Location in patent: Paragraph 0243; 0244; 0246
[4] Patent: WO2015/185207, 2015, A1. Location in patent: Page/Page column 190; 191
[5] Patent: WO2015/185208, 2015, A1. Location in patent: Page/Page column 147; 148

TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE Suppliers

China 90 Germany 1 India 1 United Kingdom 2 United States 11 Global 105

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View Lastest Price from TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE manufacturers

Career Henan Chemical Co

Product: TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE 930785-40-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500kg
Release date: 2020-03-06

930785-40-3, TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATERelated Search:

TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-9-CARBOXYLATE

9-Boc-1-Oxa-4,9-diazaspiro[5.5]undecane

1-Oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid, 1,1-diMethylethyl ester

1-Oxa-4,9-diaza-spiro[5.5]undecane-9-carboxylic acid tert-butyl ester

1-Oxa-4,9-diazaspiro[5.5]undecane,N9-BOCprotected

EOS-62238

tert-butyl1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate 1-

1,1-Dimethylethyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

1-Oxa-9-Boc-4,9-diazaspiro[5.5]undecane

tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate - [B13035]

tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecan-9-carboxylate

930785-40-3