1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
- Product Name
- 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
- CAS No.
- 198477-89-3
- Chemical Name
- 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE
- Synonyms
- 1-(5-broMo-2-fluorophenyl)ethan-1-one;2-Fluoro-5-bromoacetophenone;5-BROMO-2-FLUOROPHENYLETHANONE;5'-Bromo-2'-fluoroacetophenone;5‘-BroMo-2'-fluoroacetophenone;1-(5-BROMO-2-FLUOROPHENYL)ETHANONE;5-BroMo-2-fluorophenyl)-1-ethanone;5'-Bromo-2'-fluoroacetophenone,98%;1-(5-BROMO-2-FLUORO-PHENYL)-ETHANON;Ethanone, 1-(5-broMo-2-fluorophenyl)-
- CBNumber
- CB72458011
- Molecular Formula
- C8H6BrFO
- Formula Weight
- 217.04
- MOL File
- 198477-89-3.mol
1-(5-BROMO-2-FLUOROPHENYL)ETHANONE Property
- Melting point:
- 42 °C
- Boiling point:
- 251℃
- Density
- 1.535
- Flash point:
- 106℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- color
- White to Orange to Green
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C8H6BrFO/c1-5(11)7-4-6(9)2-3-8(7)10/h2-4H,1H3
- InChIKey
- XNRQIHIOKXQSPG-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC(Br)=CC=C1F)C
Safety
- HazardClass
- IRRITANT
- HS Code
- 2914390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- KOB0158
- Product name
- 1-(5-Bromo-2-fluorophenyl)-1-ethanone
- Packaging
- 1 g
- Price
- $330
- Updated
- 2025/07/31
- Product number
- B5237
- Product name
- 5'-Bromo-2'-fluoroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $34
- Updated
- 2025/07/31
- Product number
- B5237
- Product name
- 5'-Bromo-2'-fluoroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $132
- Updated
- 2025/07/31
- Product number
- B691878
- Product name
- 5''-Bromo-2''-fluoroacetophenone
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 054340
- Product name
- 1-(5-Bromo-2-fluorophenyl)-1-ethanone
- Purity
- 95+%
- Packaging
- 5g
- Price
- $44
- Updated
- 2021/12/16
1-(5-BROMO-2-FLUOROPHENYL)ETHANONE Chemical Properties,Usage,Production
Uses
5'-Bromo-2'-fluoroacetophenone is an intermediate used in pharmaceuticals.
Preparation
Synthesis of 1-(5-Bromo-2-fluorophenyl)ethanone: In a dry flask, a solution of 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide (3.73 g, 14.2 mmol) in tetrahydrofuran (24 mL) was treated dropwise with a solution of methyl magnesium chloride (3 M in THF, 5.69 mL, 17 mmol) at 12–16 °C. After complete addition, the reaction mixture was heated to reflux. After 20 min, the resulting white suspension was quenched with saturated ammonium chloride solution (25 mL) under ice cooling. The mixture was then diluted with ethyl acetate (50 mL), and the aqueous layer was separated and re-extracted with ethyl acetate (50 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified to afford 1-(5-bromo-2-fluorophenyl)ethanone as a pale yellow solid (2.6 g, 84% yield), with an Rf = 0.55 (silica gel, eluent: heptane/ethyl acetate = 4:1).
Synthesis
910912-20-8
75-16-1
198477-89-3
Synthesis of 1-(5-bromo-2-fluorophenyl)ethanone (15): To a stirred solution of 5-bromo-2-fluoro-N-methoxy-N-methylbenzamide (14) (106 g, 404 mmol) in anhydrous tetrahydrofuran (THF) (1.7 L) was slowly added, under nitrogen protection and at 0 °C, an ether solution of methylmagnesium bromide (3.0 M, 270 mL, 808 (3.0 M, 270 mL, 808 mmol). After addition, the reaction was continued to be stirred at 0 °C for 6.5 hours. After completion of the reaction, the reaction solution was slowly poured into 2N hydrochloric acid (1 L) and gradually warmed to room temperature. The reaction mixture was extracted with ethyl acetate (2 x 1 L). The organic phases were combined, washed sequentially with saturated aqueous sodium bicarbonate (500 mL) and brine (500 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford the target product 15 (85.2 g, 97% yield) as an orange oil. The product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.98 (dd, J = 6.4, 2.6 Hz, 1H), 7.61 (ddd, J = 8.7, 4.3, 2.6 Hz, 1H), 7.05 (dd, J = 10.4, 8.7 Hz, 1H), 2.64 (d, J = 4.9 Hz, 3H); ESI MS m/ z 217 [M + H]+.
References
[1] Patent: WO2011/44184, 2011, A1. Location in patent: Page/Page column 103-104
1-(5-BROMO-2-FLUOROPHENYL)ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(5-BROMO-2-FLUOROPHENYL)ETHANONE Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE manufacturers
- Product
- 1-(5-Bromo-2-fluorophenyl)ethanone 198477-89-3
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 1-(5-BROMO-2-FLUOROPHENYL)ETHANONE 198477-89-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11