5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- Product Name
- 5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- CAS No.
- 954239-61-3
- Chemical Name
- 5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER
- Synonyms
- Methyl 5-Bromobenzoxazole-2-carboxylate;Methyl 5-broMobenzo[d]oxazole-2-carboxylate;methyl 5-bromo-1,3-benzoxazole-2-carboxylate;5-Bromo-2-benzoxazolecarboxylic acid methyl ester;5-bromo-benzoxazole-2-carboxylic acid methyl ester;5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER;2-Benzoxazolecarboxylic acid, 5-bromo-, methyl ester
- CBNumber
- CB72459038
- Molecular Formula
- C9H6BrNO3
- Formula Weight
- 256.05
- MOL File
- 954239-61-3.mol
5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Property
- storage temp.
- Sealed in dry,Room Temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 6440AC
- Product name
- Methyl5-bromobenzo[d]oxazole-2-carboxylate
- Packaging
- 100mg
- Price
- $181
- Updated
- 2021/12/16
- Product number
- HCH0032883
- Product name
- 2-BENZOXAZOLECARBOXYLIC ACID, 5-BROMO-, METHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1452.87
- Updated
- 2021/12/16
- Product number
- A157930
- Product name
- Methyl5-bromobenzo[d]oxazole-2-carboxylate
- Purity
- 97%
- Packaging
- 100mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- A157930
- Product name
- Methyl5-bromobenzo[d]oxazole-2-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $166
- Updated
- 2021/12/16
- Product number
- UT01831
- Product name
- Methyl5-bromobenzo[d]oxazole-2-carboxylate
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $200
- Updated
- 2021/12/16
5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Synthesis
132244-31-6
124-38-9
74-88-4
954239-61-3
Catalyst (9.9 mg, 0.025 mmol, 5 mol%), potassium tert-butoxide (0.0672 g, 0.6 mmol), DMF (3.0 mL) and 5-bromobenzoxazole (99.01 mg, 0.5 mmol) were added to the reaction flask under argon protection. The reaction mixture was stirred at 80 °C for 18 h under carbon dioxide atmosphere at atmospheric pressure. Upon completion of the reaction, the system was cooled to 65 °C, followed by the addition of iodomethane (93 μL, 1.5 mmol) and continued stirring at 65 °C for 1 hour. At the end of the reaction, the mixture was cooled to room temperature and the reaction was quenched with deionized water. The reaction mixture was extracted with ethyl acetate, and the organic phases were combined and purified by column chromatography (eluent: ethyl acetate/petroleum ether, 1:10, v/v). The target product methyl 5-bromobenzo[D]oxazole-2-carboxylate was obtained in 85% yield.
References
[1] Green Chemistry, 2018, vol. 20, # 5, p. 989 - 996
[2] Patent: CN106565623, 2017, A. Location in patent: Paragraph 0035
5-BROMO-BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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