ChemicalBook > CAS DataBase List > 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER

3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER

Product Name: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER
CAS No.: 480449-99-8
Chemical Name: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER
Synonyms: benzyl 3-hydroxycyclobutane-1-carboxylate;benzyl 3-hydroxycyclobutanecarboxylate;Benzyl 3-hydroxycyclobutanecarboxylate - B10561;3-Hydroxy-cyclobutanecarboxylic acid benzyl este;3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER;Cyclobutanecarboxylic acid, 3-hydroxy-, phenylMethyl ester
CBNumber: CB72466414
Molecular Formula: C12H14O3
Formula Weight: 206.24
MOL File: 480449-99-8.mol

Less

3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER Property

Boiling point:: 326.2±35.0 °C(Predicted)
Density: 1.240
storage temp.: Sealed in dry,Room Temperature
pka: 14.72±0.40(Predicted)
form: solid
Appearance: Colorless to light yellow Liquid

Less

Safety

HS Code: 2918999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHB00064
Product name: Benzyl 3-hydroxycyclobutanecarboxylate
Purity: AldrichCPR
Packaging: 1 g
Price: $639
Updated: 2025/07/31

TRC

Product number: B297043
Product name: Benzyl3-Hydroxycyclobutanecarboxylate
Packaging: 1g
Price: $100
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2623-1-63
Product name: Benzyl 3-hydroxycyclobutanecarboxylate
Packaging: 250mg
Price: $38
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2623-1-63
Product name: Benzyl 3-hydroxycyclobutanecarboxylate
Packaging: 1g
Price: $125
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2623-1-63
Product name: Benzyl 3-hydroxycyclobutanecarboxylate
Packaging: 5G
Price: $450
Updated: 2021/12/16

Less

3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER Chemical Properties,Usage,Production

Synthesis

198995-91-4

480449-99-8

Example 261: General procedure for the synthesis of benzyl 3-hydroxycyclobutanecarboxylate from benzyl 3-oxocyclobutanecarboxylate: 1. triethylamine (2 mL, 14.04 mmol) and benzyl bromide (1.2 mL, 10.0 mmol) were added to a solution of 3-oxocyclobutane-1-carboxylic acid (1.0 g, 8.77 mmol) in THF (10 mL), and stirred for 2 hours at room temperature. EtOAc (10 mL) was added and the mixture was washed sequentially with water, 1 M hydrochloric acid and brine. The organic layer was dried with sodium sulfate and concentrated in vacuum. The residue was purified by fast column chromatography (FCC) using a gradient elution with a hexane solution of 0-15% EtOAc to give benzyl 3-oxocyclobutane-1-carboxylate (0.938 g, 53%). 2. Benzyl 3-oxocyclobutane-1-carboxylate (0.800 g, 3.92 mmol) was dissolved in a mixture of THF (2.5 mL) and water (2.5 mL), and cooled to 0°C. Sodium borohydride (0.051 g, 1.96 mmol) was added and stirred at room temperature for 1 hour. After vacuum concentration, EtOAc (10 mL) was added, washed sequentially with water and brine, and the organic layer was dried with sodium sulfate and concentrated. The residue was purified by FCC and eluted using a gradient of 0-10% EtOAc in hexane solution to give benzyl 3-hydroxycyclobutane-1-carboxylate (0.715 g, 88%). 3. Benzyl 3-hydroxycyclobutane-1-carboxylate (0.400 g, 1.94 mmol) was dissolved in THF (10 mL) and phenol (0.547 g, 5.83 mmol) and triphenylphosphine (0.662 g, 2.52 mmol) were added. Diethyl azodicarboxylate (0.4 mL, 2.52 mmol) was added slowly and stirred at room temperature for 24 hours. After evaporation, it was extracted with EtOAc (3 x 10 mL) and the organic layer was washed with brine and concentrated. The residue was purified by FCC and eluted using a gradient of 0-15% EtOAc in hexane solution to give benzyl 3-phenoxycyclobutane-1-carboxylate (0.450 g, 82%). 4. Benzyl 3-phenoxycyclobutane-1-carboxylate (0.400 g, 1.42 mmol) was dissolved in EtOH (10 mL) and 10% palladium carbon (0.010 g) was added. The solution was stirred at room temperature under hydrogen atmosphere for 2 hours. The filtrate was filtered and evaporated and the residue was purified by FCC using a gradient elution with hexane solution of 0-10% EtOAc to give 3-phenoxycyclobutane-1-carboxylic acid (0.245 g, 95%). 5. Finally, 2-N-methyl-6-[5-(3-phenoxycyclobutyl)-1,2,4-oxadiazol-3-yl] was prepared from 3-phenoxycyclobutane-1-carboxylic acid (0.190 g, 0.985 mmol) and 4-amino-N-hydroxy-6-[methyl(phenyl)amino]-1,3,5-triazine-2-carboxamidine (0.150 g, 0.579 mmol) -2-N-phenyl-1,3,5-triazine-2,4-diamine in a manner similar to the preparation of Intermediate 1 (as described in Example 209). The residue was purified by FCC, eluting using a 10% MeOH hexane solution to give a mixture of isomers of benzyl 3-hydroxycyclobutanecarboxylate (0.095 g, 42%).

References

[1] Patent: WO2012/35023, 2012, A1. Location in patent: Page/Page column 91-92
[2] Patent: US2015/133422, 2015, A1. Location in patent: Paragraph 0473; 0474
[3] Patent: WO2013/74387, 2013, A1. Location in patent: Page/Page column 52
[4] Patent: EP1577301, 2005, A1. Location in patent: Page/Page column 145
[5] Patent: EP1405852, 2004, A1. Location in patent: Page 133

3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

Less

3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER Suppliers

China 70 India 1 United Kingdom 1 United States 8 Global 80

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Wuhan Luohua Medical Technology Co.,Ltd.

Tel: 13477084141; 13477084141
Fax: +86(27)65566697
Email: sales@luohuapharm.com
Country: China
ProdList: 468
Advantage: 60

Heterochem

Tel: 027-88041443 13072715837
Fax: 027-51829379
Email: sales@hetero-chem.com
Country: China
ProdList: 696
Advantage: 58

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd.

Tel: 19943855286
Fax: 0371-53392065
Email: triz-4@trizpharma.cn
Country: China
ProdList: 1936
Advantage: 56

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9722
Advantage: 58

Henan Aosman Biotechnology Co., LTD

Tel: 0371-0371-61318675 17719817155
Fax: 0371-61318675
Email: sales@xlinebio.com
Country: China
ProdList: 2857
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Shanghai TenSus Biotechnology Co., Ltd.

Tel: 021-50895067 18616507272
Fax: 021-50895067
Email: tensus@163.com
Country: China
ProdList: 8073
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Chengdu Feibo Pharm Technology Co., Ltd

Tel: +86 028-84641798 15982321820
Email: abby@arkpharm.com
Country: China
ProdList: 10000
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

Jiaxing Hengrui Biotechnology Co. LTD

Tel: 0573-0573-82672231 13757365595
Fax: QQ：715584339
Email: regen_chemical1@163.com
Country: China
ProdList: 4839
Advantage: 58

Qingfeng Chem

Tel: 18672943286
Email: brian_zhao@whqfchem.com
Country: China
ProdList: 440
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

Shandong Shenglan Chemical Technology Co. Ltd

Tel: 17806220283
Fax: QQ/wx：9291866
Email: info@samelabs.com
Country: China
ProdList: 569
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Ruipu Medical Technology Co., Ltd

Tel: 15895968936
Fax: qq 1018762393
Email: 1018762393@qq.com
Country: China
ProdList: 9999
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

JinOu Biomedical (Nanjing) Co., Ltd.

Tel: 13000000000
Fax: jinoupharma@163
Email: jinoupharma@163.com
Country: China
ProdList: 11721
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Fax: 025 86918232
Email: sales_china@pharmablock.com
Country: China
ProdList: 10000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 15870833005
Email: 2232044025@qq.com
Country: China
ProdList: 8206
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 13901585132
Email: 2261760024@qq.com
Country: China
ProdList: 4900
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd

Tel: 15553348166
Email: m15553348166@163.com
Country: China
ProdList: 9967
Advantage: 58

Shanghai New Bo Biomedical Technology Co., LTD

Tel: 021-18800336901 15821600833
Email: muyouren139@163.com
Country: China
ProdList: 385
Advantage: 58

Shandong Shenganbei New Energy Co. , Ltd. . Nanjing branch

Tel: 18761883648
Email: sab202211@163.com
Country: China
ProdList: 1665
Advantage: 58

Yuncheng Hengli Biotechnology Co. , Ltd.

Tel: 15552097599
Email: 847061514@qq.com
Country: China
ProdList: 500
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Huzhou Chengbo Biotechnology Co., Ltd

Tel: 13626726938
Country: China
ProdList: 3879
Advantage: 58

Shanghai Kailedia Biopharmaceutical Co., Ltd

Tel: 021-18800336901 18800336901
Email: muyouren139@163.com
Country: China
ProdList: 179
Advantage: 58

Less

View Lastest Price from 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER manufacturers

Career Henan Chemical Co

Product: 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER 480449-99-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

480449-99-8, 3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTERRelated Search:

3-HYDROXY-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER

benzyl 3-hydroxycyclobutanecarboxylate

3-Hydroxy-cyclobutanecarboxylic acid benzyl este

Cyclobutanecarboxylic acid, 3-hydroxy-, phenylMethyl ester

benzyl 3-hydroxycyclobutane-1-carboxylate

Benzyl 3-hydroxycyclobutanecarboxylate - B10561

480449-99-8