1H-INDAZOLE, 5-IODO-1-METHYL-

Product Name: 1H-INDAZOLE, 5-IODO-1-METHYL-
CAS No.: 1072433-59-0
Chemical Name: 1H-INDAZOLE, 5-IODO-1-METHYL-
Synonyms: 5-iodo-1-methylindazole;5-Iodo-1-methyl-1H-indazole;1H-INDAZOLE, 5-IODO-1-METHYL-
CBNumber: CB72467512
Molecular Formula: C8H7IN2
Formula Weight: 258.06
MOL File: 1072433-59-0.mol

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1H-INDAZOLE, 5-IODO-1-METHYL- Property

Density: 1.89
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: Y5166
Product name: 5-Iodo-1-methyl-1H-indazole
Packaging: 1g
Price: $251
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0367475
Product name: 5-IODO-1-METHYL-1H-INDAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $495.84
Updated: 2021/12/16

Ambeed

Product number: A104001
Product name: 5-Iodo-1-methyl-1H-indazole
Purity: 98%
Packaging: 250mg
Price: $72
Updated: 2021/12/16

Ambeed

Product number: A104001
Product name: 5-Iodo-1-methyl-1H-indazole
Purity: 98%
Packaging: 1g
Price: $139
Updated: 2021/12/16

Chemenu

Product number: CM150857
Product name: 5-iodo-1-methyl-1H-indazole
Purity: 98%
Packaging: 1g
Price: $177
Updated: 2021/12/16

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1H-INDAZOLE, 5-IODO-1-METHYL- Chemical Properties,Usage,Production

Synthesis

50593-24-3

1072433-59-0

General procedure for the synthesis of 5-iodo-1-methyl-1H-indazole from 1-methyl-1H-indazol-5-amine: 1. add 1-methyl-1H-indazol-5-amine (500 mg, 3.40 mmol) to a mixture of concentrated sulfuric acid (1.3 mL) and water (5.5 mL) at 0 °C. 2. a solution of sodium nitrite (258 mg, 3.74 mmol) in water (0.5 mL) was added dropwise to the above mixture. 3. The reaction mixture was stirred at 0 °C for 10 min. 4. The stirred mixture was added dropwise to a solution of sodium iodide (1.5 g) in water (4.5 mL) cooled to 0 °C. 5. After addition, the reaction mixture was heated to 90°C and held for 20 minutes. 6. After completion of the reaction, the resulting mixture was alkalized with dilute sodium hydroxide solution and extracted with ethyl acetate. 7. The organic phase was washed with brine, dried over magnesium sulfate and then concentrated in vacuum. 8. The residue was purified by fast column chromatography on silica gel using a petroleum ether solution of 20% EtOAc as eluent to afford the title compound 5-iodo-1-methyl-1H-indazole (475 mg, 54% yield). 1H NMR (DMSO D6, 400 MHz) δ 4.03 (3H, s), 7.52 (1H, d), 7.63 (1H, dd), 7.99 (1H, s), 8.17 (1H, s).

References

[1] Patent: WO2008/128009, 2008, A2. Location in patent: Page/Page column 47-48

1H-INDAZOLE, 5-IODO-1-METHYL- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-INDAZOLE, 5-IODO-1-METHYL- Suppliers

China 52 India 1 Ukraine 1 United States 7 Global 61

ZEROSCHEM.CO.,LTD.

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3A Chemicals

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1072433-59-0, 1H-INDAZOLE, 5-IODO-1-METHYL-Related Search:

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1H-INDAZOLE, 5-IODO-1-METHYL-

5-iodo-1-methylindazole

1072433-59-0