ChemicalBook > CAS DataBase List > TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE

TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE

Product Name
TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE
CAS No.
871022-62-7
Chemical Name
TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE
Synonyms
4-Fluoro-4-(Boc-aminomethyl)piperidine;4-(Boc-aMinoMethyl)-4-fluoropiperidine;TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE;tert-butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate;tert-butyl N-(4-fluoro-4-piperidyl)-N-methyl-carbamate;tert-?Butyl (4-?Fluoro-?4-?piperidinyl)?methylcarbamate;4-[(tert-Butoxycarbonylamino)methyl]-4-fluoropiperidine;tert-butyl (4-Fluoropiperidin-4-yl)methylcarbamate hydrochloride;[(4-Fluoro-4-piperidinyl)methyl]carbamic acid 1,1-dimethylethyl ester;Carbamic acid, [(4-fluoro-4-piperidinyl)methyl]-, 1,1-dimethylethyl ester (9CI)
CBNumber
CB72468195
Molecular Formula
C11H21FN2O2
Formula Weight
232.29
MOL File
871022-62-7.mol
More
Less

TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE Property

Boiling point:
324.8±27.0 °C(Predicted)
Density 
1.07±0.1 g/cm3(Predicted)
storage temp. 
2-8°C, protect from light
pka
12.72±0.46(Predicted)
Appearance
White to off-white Solid
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B809608
Product name
tert-​Butyl(4-​Fluoro-​4-​piperidinyl)​methylcarbamate
Packaging
100mg
Price
$95
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0419602
Product name
TERT-BUTYL N-[(4-FLUOROPIPERIDIN-4-YL)METHYL]CARBAMATE
Purity
95.00%
Packaging
5MG
Price
$450.45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-3-7Q
Product name
tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
Purity
97.0%
Packaging
250mg
Price
$490
Updated
2021/12/16
Matrix Scientific
Product number
122027
Product name
4-(Boc-aminomethyl)-4-fluoropiperidine
Purity
97.0%
Packaging
1g
Price
$650
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-3-7Q
Product name
tert-Butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
Purity
97.0%
Packaging
1g
Price
$1490
Updated
2021/12/16
More
Less

TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE Chemical Properties,Usage,Production

Uses

tert-?Butyl (4-?Fluoro-?4-?piperidinyl)?methylcarbamate is a reagent used in the preparation of cyanophenylglycine derivatives which may act as reversible inhibitors of lysine demethylase 1 which is involved in the differentiation of leukemia stem cells in ACM.

Synthesis

871022-60-5

871022-62-7

N-benzoyl-4-tert-butoxycarbonylaminomethyl-4-fluoropiperidine (the product of Step 3 of Example 15, 4.42 g, 13.1 mmol) was used as a raw material and reacted with NaOH (2.62 g, 65.5 mmol) at reflux in a mixed solvent of H2O (9.00 mL) and ethanol (90.0 mL) for 15 hours. After completion of the reaction, the mixture was concentrated in vacuum. Water and chloroform were added to the concentrated residue and the organic layer was separated. The organic layer was dried with magnesium sulfate and concentrated under reduced pressure to remove the solvent. The resulting solid was recrystallized by hexane-CH2Cl2 mixed solvent to give 1.77 g (58% yield) of the target product ((4-fluoropiperidin-4-yl)methyl)carbamic acid tert-butyl ester as a colorless solid. Mass spectrum (ESI) m/z: 233 (M + H)+. 1H NMR (CDCl3) δ 4.93 (1H, m), 3.30 (2H, dd, J = 21.5,6.3Hz), 2.91 (4H, m), 1.88-1.34 (4H, m), 1.45 (9H, s). No signal corresponding to the amino group was observed.

References

[1] Patent: US2005/277671, 2005, A1. Location in patent: Page/Page column 38
[2] Patent: US2006/194842, 2006, A1. Location in patent: Page/Page column 37

TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE Suppliers

China 39 India 2 United States 9 Global 50
Suzhou Sibian Chemical Technology Co.,Ltd.
Tel
0512-65617459 18915409046
Fax
0512-65617459
Email
sales@sibian-chem.com
Country
China
ProdList
1922
Advantage
55
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
1941
Advantage
62
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
Shanghai Brain Biotechnology Co., Ltd.
Tel
13564638271
Fax
021-68948280
Email
shhjiang1977@163.com
Country
China
ProdList
2987
Advantage
55
BioPharmaMatrix,Inc.
Tel
0510-86010668
Fax
0510-86010668
Email
sales@biopharmamatrix.com
Country
China
ProdList
4743
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Huaxing Biological Technology Co., Ltd.
Tel
18621295758
Fax
-QQ:1449085402
Email
1449085402@qq.com
Country
China
ProdList
1978
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Shanghai Benso Pharmaceutical Technology Co., Ltd.
Tel
15088289376
Email
248775804@qq.com
Country
China
ProdList
4995
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
CD Chemical Group Limited
Tel
+8615986615575
Fax
0086-13651442114
Email
info@codchem.com
Country
China
ProdList
20342
Advantage
58
Chengdu Feibo Pharm Technology Co., Ltd
Tel
+86 028-84641798 15982321820
Email
abby@arkpharm.com
Country
China
ProdList
10000
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Shanghai Sunmonth Technology Co., LTD
Tel
15216675652
Email
xuanyuelj@163.com
Country
China
ProdList
2864
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9814
Advantage
58
Shanghai Ruipu Medical Technology Co., Ltd
Tel
15895968936
Fax
qq 1018762393
Email
1018762393@qq.com
Country
China
ProdList
9999
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Suzhou rich Medicine Technical Co;Ltd
Tel
15221533763
Email
suzhourich@163.com
Country
China
ProdList
985
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188
Fax
025 86918232
Email
sales_china@pharmablock.com
Country
China
ProdList
10000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Bejing Famous Pharmaceutical Technology Co., Ltd.
Tel
15811073878
Email
2559355526@qq.com
Country
China
ProdList
10701
Advantage
58
Shanghai Lingfu Pharmaceutical Research Co. LTD
Tel
+86(21)5895 0110 19945755304
Email
sales@chemany.com
Country
China
ProdList
9984
Advantage
58
Suzhou Yueheng Pharmaceutical Technology Co., Ltd.
Tel
15962211760
Email
2665833871@qq.com
Country
China
ProdList
808
Advantage
58
Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 13795461237
Email
zhuruyan@jskchem.com
Country
China
ProdList
49234
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
syeu@accelachem.com
Country
China
ProdList
11015
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Elucigen bio
Tel
13501719342; 13501719342
Email
wayne.zheng@elucigenbio.com
Country
China
ProdList
5000
Advantage
58
Henan Inokai New Materials Co., Ltd
Tel
13253687330
Email
3921118937@qq.com
Country
China
ProdList
1958
Advantage
58
Suzhou Yimaike Pharmaceutical Co., Ltd.
Tel
18701861866
Email
suzhouyimaike@163.com
Country
China
ProdList
167
Advantage
58
Anyang Xiyan Technology Co., LTD
Tel
17525889330
Email
17525889330@163.com
Country
China
ProdList
7850
Advantage
58
Suzhou ARTK Medchem Co., Ltd.
Tel
+86-512-68323658 +86-18168183658
Email
sales1@artkmedchem.com
Country
China
ProdList
39002
Advantage
58
HANGZHOU LEAP CHEM CO., LTD.
Tel
+86-571-87711850
Email
market18@leapchem.com
Country
China
ProdList
24727
Advantage
58

871022-62-7, TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATERelated Search:


  • TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE
  • 4-(Boc-aMinoMethyl)-4-fluoropiperidine
  • [(4-Fluoro-4-piperidinyl)methyl]carbamic acid 1,1-dimethylethyl ester
  • 4-[(tert-Butoxycarbonylamino)methyl]-4-fluoropiperidine
  • tert-butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
  • tert-butyl (4-Fluoropiperidin-4-yl)methylcarbamate hydrochloride
  • Carbamic acid, [(4-fluoro-4-piperidinyl)methyl]-, 1,1-dimethylethyl ester (9CI)
  • tert-?Butyl (4-?Fluoro-?4-?piperidinyl)?methylcarbamate
  • tert-butyl N-(4-fluoro-4-piperidyl)-N-methyl-carbamate
  • 4-Fluoro-4-(Boc-aminomethyl)piperidine
  • 871022-62-7