ert-butyl 4-(bromomethylene)piperidine-1-carboxylate
- Product Name
- ert-butyl 4-(bromomethylene)piperidine-1-carboxylate
- CAS No.
- 1020329-80-9
- Chemical Name
- ert-butyl 4-(bromomethylene)piperidine-1-carboxylate
- Synonyms
- 4-Bromomethylene-piper;1-Boc-4-(Bromomethylene);1-Boc-4-(BroMoMethylene)piperidine;1-N-Boc-4-(bromomethylene)piperidine;Tert-Butyl4-(bromomethylene)piperidine-1-carboxylate;ert-butyl 4-(bromomethylene)piperidine-1-carboxylate;Tert-butyl 4-(bromomethylene)piperidin-1-carboxylate;tert-butyl 4-(bromomethylidene)piperidine-1-carboxylate;4-Bromomethylene-piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylicacid, 4-(bromomethylene)-, 1,1-dimethy...
- CBNumber
- CB72470394
- Molecular Formula
- C11H18BrNO2
- Formula Weight
- 276.17
- MOL File
- 1020329-80-9.mol
ert-butyl 4-(bromomethylene)piperidine-1-carboxylate Property
- Boiling point:
- 317.7±35.0 °C(Predicted)
- Density
- 1.390
- storage temp.
- 2-8°C
- pka
- -1.51±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C11H18BrNO2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h8H,4-7H2,1-3H3
- InChIKey
- IYVCMYUDZHFNJM-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC/C(=C\Br)/CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B643755
- Product name
- 1-Boc-4-(bromomethylene)piperidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 0546AA
- Product name
- 1-Boc-4-(Bromomethylene)piperidine
- Packaging
- 50mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- 119166
- Product name
- 1-Boc-4-(Bromomethylene)piperidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $324
- Updated
- 2021/12/16
- Product number
- OR322891
- Product name
- tert-Butyl 4-(bromomethylene)piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $428
- Updated
- 2021/12/16
- Product number
- 4H56-9-6C
- Product name
- tert-Butyl 4-(bromomethylene)piperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $508
- Updated
- 2021/12/16
ert-butyl 4-(bromomethylene)piperidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
305794-65-4
1020329-80-9
The general procedure for the synthesis of tert-butyl 1-N-tert-butoxycarbonyl-4-(bromomethylene)piperidine from 4-(dibromomethylene)piperidine-1-carboxylate was carried out as follows: tert-butyl 4-(dibromomethylene)piperidine-1-carboxylate (12 g, 33.8 mmol) was dissolved in methanol (80 ml) under nitrogen protection and cooled to 0°C. Subsequently, tetrahydrofuran (40 ml) and ammonium chloride (14.46 g, 270 mmol) were added. The reaction mixture was stirred at 0°C for 30 min and then zinc powder (8.85 g, 135 mmol) was added. The reaction mixture was gradually warmed to room temperature and stirring was continued for 4 hours. After completion of the reaction, the mixture was filtered and the solid was washed with methanol. The filtrate was concentrated under reduced pressure to give a white solid. The solid was dissolved in a mixture of ethyl acetate and water to separate the organic and aqueous layers. The organic layer was dried with magnesium sulfate and concentrated under reduced pressure to give tert-butyl 4-(bromomethylene)piperidine-1-carboxylate (9 g, 96% yield). The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 6.26 (s, 1H), 3.19-3.43 (m, 4H), 2.15-2.35 (m, 4H), 1.41 (s, 9H). The mass spectrum (ES+) showed molecular ion peaks of 220 and 222.
References
[1] Patent: WO2013/27001, 2013, A1. Location in patent: Page/Page column 61-62
[2] Patent: WO2017/153520, 2017, A1. Location in patent: Page/Page column 55; 56
[3] Patent: US2008/261941, 2008, A1. Location in patent: Page/Page column 37
[4] Patent: WO2009/127943, 2009, A1. Location in patent: Page/Page column 27
[5] Patent: WO2009/127944, 2009, A1. Location in patent: Page/Page column 27
ert-butyl 4-(bromomethylene)piperidine-1-carboxylate Preparation Products And Raw materials
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View Lastest Price from ert-butyl 4-(bromomethylene)piperidine-1-carboxylate manufacturers
- Product
- ert-butyl 4-(bromomethylene)piperidine-1-carboxylate 1020329-80-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-16