(2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate

Product Name: (2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate
CAS No.: 130966-46-0
Chemical Name: (2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate
Synonyms: Methyl (2S,3R)-1-Boc-3-hydroxypyrrolidine-2-carboxylate;-1-tert-Butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate;1-tert-butyl 2-methyl (2S,3R)-3-hydroxypyrrolidine-1,2-dicar...;(2S,3R)-N-tert-Butoxycarbonyl-3-hydroxy-2-pyrrolidinecarboxylic;N-Boc-(2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid methyl ester;1-tert-butyl 2-methyl (2S,3R)-3-hydroxypyrrolidine-1,2-dicarboxylate;(2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate;(2S,3R)-1-(tert-BOC)-3-Hydroxypyrrolidine-2-carboxylic acid methyl ester;(2S,3R)-N-tert-Butoxycarbonyl-3-hydroxy-2-pyrrolidinecarboxylic acid Methyl ester;(2S,3R)-1-(tert-Butoxycarbonyl)-3-Hydroxypyrrolidine-2-carboxylic acid Methyl ester
CBNumber: CB72473522
Molecular Formula: C11H19NO5
Formula Weight: 245.27
MOL File: 130966-46-0.mol

More

Less

(2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate Property

Boiling point:: 335.2±42.0 °C(Predicted)
Density: 1.216±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.03±0.40(Predicted)
Appearance: Colorless to light yellow Liquid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

TRC

Product number: B813380
Product name: (2S,3R)-1-tert-Butyl2-methyl3-hydroxypyrrolidine-1,2-dicarboxylate
Packaging: 10mg
Price: $65
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0010664
Product name: (2S,3R)-1-TERT-BUTYL-2-METHYL-3-HYDROXYPYRROLIDINE-1,2-DICARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $505.88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: AAA0010664
Product name: (2S,3R)-1-TERT-BUTYL-2-METHYL-3-HYDROXYPYRROLIDINE-1,2-DICARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $1266.3
Updated: 2021/12/16

Matrix Scientific

Product number: 122528
Product name: (2S,3R)-1-(tert-BOC)-3-Hydroxypyrrolidine-2-carboxylicacidmethylester
Purity: 97.0%
Packaging: 1g
Price: $1552
Updated: 2021/12/16

ACHEMBLOCK

Product number: G-7381
Product name: (2S,3R)-1-(tert-Butoxycarbonyl)-3-Hydroxypyrrolidine-2-carboxylicacidmethylester
Purity: 97%
Packaging: 250MG
Price: $195
Updated: 2021/12/16

More

Less

(2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate Chemical Properties,Usage,Production

Synthesis

496841-07-7

130966-46-0

The general procedure for the synthesis of methyl N-Boc-(2S,3R)-3-hydroxypyrrolidine-2-carboxylate from methyl (2S,3R)-N-Boc-3-benzoyloxy-2-pyrrolidinecarboxylate was as follows: methyl (2S,3R)-N-Boc-3-benzoyloxy-2-pyrrolidinecarboxylate (2.3 g, 6.58 mmol) was dissolved in methanol ( 20 mL) and cooled to 0°C in an ice bath. 1 mol/L aqueous potassium hydroxide solution (7.3 mL) was slowly added dropwise, the reaction temperature was kept at 0 °C and the reaction was stirred for 1 hour. Upon completion of the reaction, the pH was adjusted to acidic by adding 5% aqueous potassium bisulfate solution to the reaction mixture, followed by extraction with ethyl acetate. The organic layers were combined, washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography to afford the target product methyl N-Boc-(2S,3R)-3-hydroxypyrrolidine-2-carboxylate (1.55 g, 78% yield). The mass spectrum (ESI+) showed the molecular ion peak m/z 246 ([M+H]+, relative abundance 0.5%).

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7596 - 7599
[2] Patent: EP2876105, 2015, A1. Location in patent: Paragraph 1151; 1152
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 13, p. 3015 - 3025
[4] Patent: US2005/197359, 2005, A1. Location in patent: Page/Page column 17

(2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate Suppliers

China 51 United Kingdom 1 United States 7 Global 59

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 11777
Advantage: 60

Tianjin Derchemist Science & Technology Co., Ltd.

Tel: 22-58627059 13920586291
Fax: 022-58620305
Email: zdcomcon@126.com
Country: China
ProdList: 3978
Advantage: 50

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9341
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 40000
Advantage: 60

HangZhou YuHao Chemical Technology Co., Ltd.

Tel: 0571-82693216
Fax: 0571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 2028
Advantage: 58

Shanghai Yunpun industrial Co.,Ltd

Tel: 21-61726900 15202122459
Fax: +86-21-60277507
Email: sales@yunpun.com
Country: China
ProdList: 495
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9531
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 10051
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Taian Jiaye Biotechnology Co.Ltd

Tel: 13127280945
Email: 285424065@qq.com
Country: China
ProdList: 9976
Advantage: 55

More

Less

View Lastest Price from (2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate manufacturers

Career Henan Chemical Co

Product: (2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate 130966-46-0
Price: US $0.01/KG
Min. Order: 500g
Purity: 98%; 99%
Supply Ability: 500g；1kg； 10kg; 25kg
Release date: 2020-01-08

130966-46-0, (2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylateRelated Search:

(2S,3R)-N-tert-Butoxycarbonyl-3-hydroxy-2-pyrrolidinecarboxylic

(2S,3R)-N-tert-Butoxycarbonyl-3-hydroxy-2-pyrrolidinecarboxylic acid Methyl ester

(2S,3R)-1-(tert-Butoxycarbonyl)-3-Hydroxypyrrolidine-2-carboxylic acid Methyl ester

1-tert-butyl 2-methyl (2S,3R)-3-hydroxypyrrolidine-1,2-dicarboxylate

-1-tert-Butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

(2S,3R)-1-(tert-BOC)-3-Hydroxypyrrolidine-2-carboxylic acid methyl ester

(2S,3R)-1-tert-Butyl-2-methyl-3-hydroxypyrrolidine-1,2-dicarboxylate

Methyl (2S,3R)-1-Boc-3-hydroxypyrrolidine-2-carboxylate

1,2-Pyrrolidinedicarboxylic acid, 3-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,3R)-

1-tert-butyl 2-methyl (2S,3R)-3-hydroxypyrrolidine-1,2-dicar...

(2S,3R)-3-Hydroxypyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

N-Boc-(2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid methyl ester

130966-46-0