tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

Product Name: tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
CAS No.: 865245-32-5
Chemical Name: tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
Synonyms: CAS:865245-32-5;tert-Butyl 6-(4,4,5,5-tetramethyl-1,3,2-;N-Boc-3,4-Dihydropyridine-6-boronic acid pinacol ester;1-Boc-3,4-dihydropyridine-6-boronic acid pinacol ester;1-Boc-1,4,5,6-tetrahydropyridine-2-boronic Acid Pinacol Ester;1-(tert-Butoxycarbonyl)-1,4,5,6-tetrahydropyridin-2-ylboronic acid pinacol ester;tert-butyl 6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate;tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate;TERT-BUTYL 6-(4,4, 5, 5-TETRAMETHYL-1, 3, 2-DI0XAB0R0LAN-2-YL)-3, 4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE;tert-butyl 6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate - [B25855]
CBNumber: CB72473683
Molecular Formula: C16H28BNO4
Formula Weight: 309.21
MOL File: 865245-32-5.mol

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tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Property

Boiling point:: 355.2±52.0 °C(Predicted)
Density: 1.05
storage temp.: Storage temp. -20°C
pka: -0.15±0.40(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C16H28BNO4/c1-14(2,3)20-13(19)18-11-9-8-10-12(18)17-21-15(4,5)16(6,7)22-17/h10H,8-9,11H2,1-7H3
InChIKey: LEQQJEMLERIVAW-UHFFFAOYSA-N
SMILES: C1N(C(OC(C)(C)C)=O)C(B2OC(C)(C)C(C)(C)O2)=CCC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B667855
Product name: 1-Boc-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine
Packaging: 50mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB148949
Product name: 1-Boc-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine
Packaging: 100mg
Price: $265
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB148949
Product name: 1-Boc-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine
Packaging: 250mg
Price: $530
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0002657
Product name: 1-BOC-6-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-1,2,3,4-TETRAHYDROPYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $595.35
Updated: 2021/12/16

Synthonix

Product number: B25855
Product name: tert-butyl6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate
Purity: 97.0%
Packaging: 1g
Price: $720
Updated: 2021/12/16

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tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Chemical Properties,Usage,Production

Synthesis

73183-34-3

171288-01-0

865245-32-5

General procedure for the synthesis of N-tert-butoxycarbonyl-3,4-dihydropyridine-6-boronic acid pinacol ester from bis(boronic acid) pinacol ester and tert-butyl 6-(((trifluoromethyl)sulfonyl)oxy)-3,4-dihydropyridine-1(2H)-carboxylate: To a solution of tert-butyl 6-(((trifluoromethyl)sulfonyl)oxy)-3,4-dihydropyridine-1(2H)-carboxylate (2.0 g. 6.0 mmol) to a solution of 1,4-dioxane (20 mL) was added pinacol ester of bisboronic acid (2.3 g, 9.0 mmol), potassium carbonate (1.7 g, 12.0 mmol), dichloro-bis(triphenylphosphine)palladium(II) (0.4 g, 0.6 mmol) and triphenylphosphine (0.3 g, 1.2 mmol). The reaction mixture was stirred at 90 °C overnight under nitrogen protection. After completion of the reaction, it was cooled to room temperature, the reaction mixture was diluted with ether and washed with water. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by silica gel fast column chromatography (petroleum ether: ethyl acetate = 10:1) to afford N-tert-butoxycarbonyl-3,4-dihydropyridine-6-boronic acid pinacol ester (0.9 g, 48.2% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 1.26 (12H, s), 1.51 (9H, s), 1.76 (2H , t, J = 6 Hz), 2.02-2.06 (2H, m), 3.43 (2H, t, J = 5.8 Hz), 5.20 (1H, s).

References

[1] Patent: WO2017/223243, 2017, A1. Location in patent: Paragraph 00330

tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate Suppliers

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View Lastest Price from tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate 865245-32-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Career Henan Chemical Co

Product: tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate 865245-32-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-10

865245-32-5, tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylateRelated Search:

tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

3,4-Dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1(2H)-pyridinecarboxylic acid tert butyl ester

N-Boc-3,4-Dihydropyridine-6-boronic acid pinacol ester

1-(tert-Butoxycarbonyl)-1,4,5,6-tetrahydropyridin-2-ylboronic acid pinacol ester

tert-Butyl 6-(4,4,5,5-tetramethyl-1,3,2-

tert-butyl 6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate

1-Boc-3,4-dihydropyridine-6-boronic acid pinacol ester

1-Boc-1,4,5,6-tetrahydropyridine-2-boronic Acid Pinacol Ester

6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester

tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate ISO 9001：2015 REACH

TERT-BUTYL 6-(4,4, 5, 5-TETRAMETHYL-1, 3, 2-DI0XAB0R0LAN-2-YL)-3, 4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE

CAS:865245-32-5

tert-butyl 6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate - [B25855]

865245-32-5