ChemicalBook > CAS DataBase List > 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile

Product Name: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
CAS No.: 915363-56-3
Chemical Name: 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
Synonyms: KIN001-266;Tpl2-IN-34;MAP3K8-IN-34);Cot inhibitor-2;Tpl2-IN-34 (Tpl2 inhibitor 34;Cot inhibitor-2, 10 mM in DMSO;COT INHIBITOR2; COT INHIBITOR 2;8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1;8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl]amino]quinoline-3-carbonitrile;8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile
CBNumber: CB72473885
Molecular Formula: C26H25Cl2FN8
Formula Weight: 539.43
MOL File: 915363-56-3.mol

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8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Property

Boiling point:: 713.3±70.0 °C(Predicted)
Density: 1.45
storage temp.: Store at -20°C
solubility: DMSO: ≥ 100 mg/mL (185.38 mM)
pka: 8.62±0.10(Predicted)
form: Powder
color: Light yellow to green yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0033
Product name: Cotinhibitor-2
Purity: 99.22%
Packaging: 2mg
Price: $168
Updated: 2021/12/16

ChemScene

Product number: CS-0033
Product name: Cotinhibitor-2
Purity: 99.22%
Packaging: 5mg
Price: $276
Updated: 2021/12/16

ChemScene

Product number: CS-0033
Product name: Cotinhibitor-2
Purity: 99.22%
Packaging: 10mg
Price: $444
Updated: 2021/12/16

ChemScene

Product number: CS-0033
Product name: Cotinhibitor-2
Purity: 99.22%
Packaging: 25mg
Price: $912
Updated: 2021/12/16

ChemScene

Product number: CS-0033
Product name: Cotinhibitor-2
Purity: 99.22%
Packaging: 50mg
Price: $1620
Updated: 2021/12/16

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8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Chemical Properties,Usage,Production

Uses

Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1].

Definition

ChEBI: 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethyl-4-piperidinyl)-4-triazolyl]methylamino]-3-quinolinecarbonitrile is an aminoquinoline.

in vivo

Cot inhibitor-2 (compound 34) is orally administered in rats with 100 mg/kg dosing and showed a C_max of 517 ng/mL (0.89 μM) and AUC of 4841 ng h/mL. Cot inhibitor-2 is tested in the LPS-induced TNF-α production model in female Sprague-Dawley rats. With a 25 mg/kg po dose, Cot inhibitor-2 inhibits LPS-induced TNF-α production by 83%^[1].

storage

Store at -20°C

References

[1] Junjun Wu, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8. DOI:10.1016/j.bmcl.2009.05.009

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile Suppliers

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915363-56-3, 8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-QuinolinecarbonitrileRelated Search:

Sulfenone TRIS(PENTAFLUOROPHENYL)PHOSPHINE

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]methyl]amino]-3-Quinolinecarbonitrile

8-Chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethylpiperidin-4-yl)-1H-1,2,3-triazol-4-yl]methyl]amino]quinoline-3-carbonitrile

Cot inhibitor-2

3-Quinolinecarbonitrile, 8-chloro-4-[(3-chloro-4-fluorophenyl)aMino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1,2,3-triazol-4-yl]Methyl]aMino]-

8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[[[1-(1-ethyl-4-piperidinyl)-1H-1

COT INHIBITOR2; COT INHIBITOR 2

Tpl2-IN-34

KIN001-266

Cot inhibitor-2, 10 mM in DMSO

MAP3K8-IN-34)

Tpl2-IN-34 (Tpl2 inhibitor 34

915363-56-3

C26H25Cl2FN8