AZD1152

ChemicalBook > CAS DataBase List > AZD1152

Product Name: AZD1152
CAS No.: 722543-31-9
Chemical Name: AZD1152
Synonyms: AZD1152;CS-1053;Barasertib (AZD1152);BARASERTIB; AZD-1152; AZD 1152;5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide;1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-;2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate;2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate
CBNumber: CB72476033
Molecular Formula: C26H31FN7O6P
Formula Weight: 587.54
MOL File: 722543-31-9.mol

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AZD1152 Property

Density: 1.463
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: insoluble in H2O; insoluble in EtOH; ≥5.88 mg/mL in DMSO
form: solid
pka: 1.75±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13647
Product name: AZD 1152
Purity: ≥95%
Packaging: 1mg
Price: $65
Updated: 2021/12/16

Cayman Chemical

Product number: 13647
Product name: AZD 1152
Purity: ≥95%
Packaging: 5mg
Price: $293
Updated: 2021/12/16

Cayman Chemical

Product number: 13647
Product name: AZD 1152
Purity: ≥95%
Packaging: 10mg
Price: $488
Updated: 2021/12/16

Cayman Chemical

Product number: 13647
Product name: AZD 1152
Purity: ≥95%
Packaging: 25mg
Price: $975
Updated: 2021/12/16

TRC

Product number: B129135
Product name: Barasertib
Packaging: 5mg
Price: $205
Updated: 2021/12/16

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AZD1152 Chemical Properties,Usage,Production

Uses

Barasertib. is a selective inhibitor of Aurora B kinase, which inhibits human tumor xenograft growth by inducing apoptosis.

Definition

ChEBI: AZT-1152 is a dihydrogen phosphate prodrug of a pyrazoloquinazoline aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide(HQPA) and is converted rapidly to the active AZD1152-HQPA in plasma. It has a role as a prodrug, an antineoplastic agent and an Aurora kinase inhibitor. It is a member of quinazolines, a monoalkyl phosphate, an anilide, a member of monofluorobenzenes, a member of pyrazoles, a secondary amino compound, a secondary carboxamide and a tertiary amino compound. It is functionally related to an AZD-1152.

AZD1152 Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-

AZD1152

5-[[7-[3-[Ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-3-acetamide

BARASERTIB; AZD-1152; AZD 1152

Barasertib (AZD1152)

CS-1053

2-[[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl](ethyl)amino]ethyl dihydrogen phosphate

2-(Ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl dihydrogen phosphate

722543-31-9