Methyl 3-amino-4-(methylamino)benzenecarboxylate
- Product Name
- Methyl 3-amino-4-(methylamino)benzenecarboxylate
- CAS No.
- 66315-16-0
- Chemical Name
- Methyl 3-amino-4-(methylamino)benzenecarboxylate
- Synonyms
- Methyl 3-aMino-4-(MethylaMino)benzoate;3-Amino-4-methylamino-benzoic acid methyl ester;3-Amino-4-(methylamino)benzoesaeure-methylester;Methyl 3-amino-4-(methylamino)benzenecarboxylate;Benzoic acid, 3-amino-4-(methylamino)-, methyl ester
- CBNumber
- CB72478299
- Molecular Formula
- C9H12N2O2
- Formula Weight
- 180.2
- MOL File
- 66315-16-0.mol
Methyl 3-amino-4-(methylamino)benzenecarboxylate Property
- Melting point:
- 103-105°
- Boiling point:
- 346.5±32.0 °C(Predicted)
- Density
- 1.208±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.40±0.11(Predicted)
- Appearance
- Gray to dark gray Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M328570
- Product name
- Methyl3-amino-4-(methylamino)benzoate
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 048619
- Product name
- Methyl 3-amino-4-(methylamino)benzenecarboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 048619
- Product name
- Methyl 3-amino-4-(methylamino)benzenecarboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- J94836
- Product name
- Methyl3-amino-4-(methylamino)benzoate
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- V7181
- Product name
- Methyl3-amino-4-(methylamino)benzoate
- Packaging
- 5g
- Price
- $347
- Updated
- 2021/12/16
Methyl 3-amino-4-(methylamino)benzenecarboxylate Chemical Properties,Usage,Production
Synthesis
36242-50-9
66315-16-0
General procedure for the synthesis of methyl 3-amino-4-(methylamino)benzoate from methyl 4-(methylamino)-3-nitrobenzoate: Methyl 4-(methylamino)-3-nitrobenzoate (540 mg, 2.5 mmol) was dissolved in a solvent mixture of ethyl acetate and methanol (2:1 v/v/v, 20 mL). A 10% palladium-carbon catalyst (5 mol%) was added to the solution under nitrogen protection. The reaction mixture was placed in a hydrogen atmosphere and the reaction was stirred for 4 hours. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration. The filtrate was concentrated under reduced pressure to afford the target product methyl 3-amino-4-(methylamino)benzoate. The product was characterized by LC-MS with molecular ion peak [M + 1] = 181.1. yield: 441 mg (100% yield).
References
[1] Patent: EP1502916, 2005, A1. Location in patent: Page 440
[2] Patent: WO2007/69053, 2007, A1. Location in patent: Page/Page column 34
[3] Patent: WO2008/65508, 2008, A1. Location in patent: Page/Page column 32-33; 38-40
[4] Patent: WO2017/147102, 2017, A1. Location in patent: Paragraph 00126-00127
[5] Patent: WO2017/100594, 2017, A1. Location in patent: Paragraph 00132
Methyl 3-amino-4-(methylamino)benzenecarboxylate Preparation Products And Raw materials
Raw materials
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