2,4-Dichloro-5-(iodomethyl)pyrimidine
- Product Name
- 2,4-Dichloro-5-(iodomethyl)pyrimidine
- CAS No.
- 7627-44-3
- Chemical Name
- 2,4-Dichloro-5-(iodomethyl)pyrimidine
- Synonyms
- 2,4-Dichloro-5-(iodomethyl);2,4-Dichloro-5-(iodomethyl)pyrimidine;Pyrimidine, 2,4-dichloro-5-(iodomethyl)-;2,4-Dichloro-5-(iodomethyl)pyrimidine 95%
- CBNumber
- CB72482391
- Molecular Formula
- C5H3Cl2IN2
- Formula Weight
- 288.9
- MOL File
- 7627-44-3.mol
2,4-Dichloro-5-(iodomethyl)pyrimidine Property
- Melting point:
- 78-79°
- Boiling point:
- 327.4±32.0 °C(Predicted)
- Density
- 2.141±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Solid
- pka
- -3.39±0.29(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C5H3Cl2IN2/c6-4-3(1-8)2-9-5(7)10-4/h2H,1H2
- InChIKey
- NEIMQFSSWKAYTR-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(CI)C(Cl)=N1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H272May intensify fire; oxidizer
H314Causes severe skin burns and eye damage
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P221Take any precaution to avoid mixing with combustibles/…
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P331Do NOT induce vomiting.
P363Wash contaminated clothing before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- C384245
- Product name
- ChloromethylPropylEther
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FD145166
- Product name
- 2,4-Dichloro-5-(iodomethyl)pyrimidine
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- OR18550
- Product name
- 2,4-Dichloro-5-(iodomethyl)pyrimidine
- Purity
- 95%
- Packaging
- 500mg
- Price
- $182
- Updated
- 2021/12/16
- Product number
- 3H32-M-17
- Product name
- 2,4-Dichloro-5-(iodomethyl)pyrimidine
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 3H32-M-17
- Product name
- 2,4-Dichloro-5-(iodomethyl)pyrimidine
- Packaging
- 5G
- Price
- $1114
- Updated
- 2021/12/16
2,4-Dichloro-5-(iodomethyl)pyrimidine Chemical Properties,Usage,Production
Synthesis
7627-38-5
7627-44-3
General procedure for the synthesis of 2,4-dichloro-5-(chloromethyl)pyrimidine from 2,4-dichloro-5-(iodomethyl)pyrimidine: A mixture of 2,4-dichloro-5-(chloromethyl)pyrimidine (15.0 g, 76.0 mmol) and sodium iodide (13.7 g, 91.4 mmol) in acetone was stirred for 45 min at 60 °C. After completion of the reaction, the resulting sodium chloride precipitate was removed by filtration and the precipitate was washed with acetone. The filtrates were combined and concentrated under reduced pressure to give a light yellow solid crude product. The crude product was purified by silica gel column chromatography using dichloromethane as eluent to afford 2,4-dichloro-5-(iodomethyl)pyrimidine as a light yellow solid (30.8 g, 96% yield).LC-MS (m/z): 289.3 [M + H]+.
References
[1] Patent: WO2007/136465, 2007, A2. Location in patent: Page/Page column 43-44
[2] Patent: WO2018/53373, 2018, A1. Location in patent: Paragraph 00485; 00486
[3] Patent: WO2018/160774, 2018, A1. Location in patent: Paragraph 00377; 00378
[4] Patent: WO2018/25043, 2018, A1. Location in patent: Page/Page column 24
[5] Patent: US2016/75720, 2016, A1. Location in patent: Paragraph 0323
2,4-Dichloro-5-(iodomethyl)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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