ChemicalBook > CAS DataBase List > 1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride
1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride
- Product Name
- 1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride
- CAS No.
- 432037-57-5
- Chemical Name
- 1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride
- Synonyms
- EB-1627;Gmx1777;Gmx 1777;Teglarinad;Teglarinad chloride;GMX1777;GMX 1777;GMX-1777;DAHMXVAETAAQOZ-UHFFFAOYSA-N;Teglarinad chloride (GMX1777);1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride;1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride ISO 9001：2015 REACH
- CBNumber
- CB72484643
- Molecular Formula
- C30H43ClN5O8.Cl
- Formula Weight
- 672.61
- MOL File
- 432037-57-5.mol
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1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride Property
- Melting point:
- 158-159℃
- solubility
- DMSO: 200 mg/mL (297.35 mM)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0002438
- Product name
- Teglarinad(chloride)
- Purity
- 98.07%
- Packaging
- 5mg
- Price
- $400
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0007172
- Product name
- TEGLARINAD CHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.22
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0002438
- Product name
- Teglarinad(chloride)
- Purity
- 98.07%
- Packaging
- 10mg
- Price
- $680
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0002438
- Product name
- Teglarinad(chloride)
- Purity
- 98.07%
- Packaging
- 25mg
- Price
- $1350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0002438
- Product name
- Teglarinad(chloride)
- Purity
- 98.07%
- Packaging
- 50mg
- Price
- $2200
- Updated
- 2021/12/16
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1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride Chemical Properties,Usage,Production
Uses
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis[1][2].
in vivo
GMX1777 (75 mg/kg; 24 h intravenous infusion) causes tumor regression in the IM-9 model, a small-cell lung cancer (SHP-77) model, and a colon carcinoma (HCT-116) model[2].
GMX1777 (50-100 mg/kg/d, i.m. for 5 d) with or without local tumor radiotherapy is effective for both FaDu and C666-1 tumors in vivo[1].
GMX1777 (25-400 mg/kg; 24 h intravenous infusion) is quickly converted to GMX1778 in plasma of mice with a half-life of GMX1777 less than 0.7 h[2].
| Animal Model: | CB17 SCID/SCID female mice bearing subcutaneous IM-9 multiple myeloma tumors[2] |
| Dosage: | 18.75, 35, 75 mg/kg |
| Administration: | A 24 h intravenous infusion |
| Result: | Induced a nearly complete regression of the tumors and a significant tumor growth delay at the dose of 75 mg/kg. Reduced IM-9 tumor growth moderately at 37.5 mg/kg. |
References
[1] Kato H, et, al. Efficacy of combining GMX1777 with radiation therapy for human head and neck carcinoma. Clin Cancer Res. 2010 Feb 1;16(3):898-911. DOI:10.1158/1078-0432.CCR-09-1945
[2] Beauparlant P, et, al. Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anticancer Drugs. 2009 Jun;20(5):346-54. DOI:10.1097/CAD.0b013e3283287c20
1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride Suppliers
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View Lastest Price from 1-[[[[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]carbonyl]oxy]methyl]-4-[N'-cyano-N''-[6-[4-chlorophenoxy]hexyl]guanidino]pyridinium chloride manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- GMX1777 432037-57-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26