2-Chlorophenylboronic acid
- Product Name
- 2-Chlorophenylboronic acid
- CAS No.
- 3900-89-8
- Chemical Name
- 2-Chlorophenylboronic acid
- Synonyms
- 2-CHLOROBENZENEBORONIC ACID;2-CHLOROPHENYLBORNIC ACID;AKOS BRN-0009;RARECHEM AH PB 0177;2-Chlorophenylboroni;2-Chlorophenylboronic;2-chlorobenzeneboronic;Chlorophenylboronicacid;2-CHLORPHENYLBORONSAEURE;2- Chlorobenboronic acid
- CBNumber
- CB7248469
- Molecular Formula
- C6H6BClO2
- Formula Weight
- 156.37
- MOL File
- 3900-89-8.mol
2-Chlorophenylboronic acid Property
- Melting point:
- 92-102 °C (lit.)
- Boiling point:
- 306.3±44.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO, Methanol.
- form
- Crystalline Powder
- pka
- 8.23±0.58(Predicted)
- color
- White
- BRN
- 3030414
- InChI
- InChI=1S/C6H6BClO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H
- InChIKey
- RRCMGJCFMJBHQC-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC=C1Cl)(O)O
- CAS DataBase Reference
- 3900-89-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- TSCA
- No
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 445215
- Product name
- 2-Chlorophenylboronic acid
- Purity
- ≥95.0%
- Packaging
- 1g
- Price
- $36.68
- Updated
- 2025/07/31
- Product number
- 445215
- Product name
- 2-Chlorophenylboronic acid
- Purity
- ≥95.0%
- Packaging
- 5g
- Price
- $98.03
- Updated
- 2025/07/31
- Product number
- C1705
- Product name
- 2-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
- Product number
- C1705
- Product name
- 2-Chlorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- C376510
- Product name
- 2-Chlorophenylboronic acid
- Packaging
- 25g
- Price
- $350
- Updated
- 2021/12/16
2-Chlorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
white crystalline powder
Uses
suzuki reaction
Uses
2-Chlorophenylboronic Acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
Synthesis
694-80-4
3900-89-8
Step (f): n-BuLi (2.5 M, n-hexane solution, 2.5 mL, 1.2 eq., 6.3 mmol) was slowly added dropwise under nitrogen protection to a solvent mixture of toluene and THF (4: 1, 10 mL, 10 mL) containing 2-bromo chlorobenzene (I) (1 g, 0.6 mL, 5.2 mmol) and triisopropyl borate (1.44 mL, 1.2 eq., 6.27 mmol). 1, 10 mL) in a reaction temperature of -70°C and a dropwise addition time of 1 hour. After the dropwise addition, the reaction mixture was continued to be stirred at -70°C for 0.5 hr. Subsequently, the reaction system was slowly warmed to -20 °C and the reaction was quenched by the addition of 2N HCl solution (5 mL). After the reaction mixture was brought to room temperature, it was extracted with dichloromethane. The organic phases were combined, dried and concentrated to give a white solid. The solid was purified by recrystallization from acetonitrile to give the target product 2-chlorophenylboronic acid in 98% yield (800 mg).
References
[1] Patent: WO2013/90725, 2013, A1. Location in patent: Page/Page column 68
[2] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 590 - 603
[3] Journal of Organic Chemistry, 2002, vol. 67, # 15, p. 5394 - 5397
2-Chlorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chlorophenylboronic acid manufacturers
- Product
- 2-Chlorophenylboronic acid 3900-89-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 5000kg/month
- Release date
- 2021-10-28
- Product
- 2-Chlorophenylboronic acid 3900-89-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28
- Product
- 2-Chlorophenylboronic acid 3900-89-8
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-21