Bardoxolone
- Product Name
- Bardoxolone
- CAS No.
- 218600-44-3
- Chemical Name
- Bardoxolone
- Synonyms
- CCDO;CDDO;CS-321;RTA 401;Bardoxolone;RTA-401;RTA401;CDDO(Bardoxolone);Bardoxolone (CDDO);bardoxolone RTA 401;BARDOXOLONE;CDDO;RTA 401
- CBNumber
- CB72484825
- Molecular Formula
- C31H41NO4
- Formula Weight
- 491.66
- MOL File
- 218600-44-3.mol
Bardoxolone Property
- Melting point:
- 180-182 °C
- Boiling point:
- 632.9±55.0 °C(Predicted)
- Density
- 1.18
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- ≥49.2 mg/mL in DMSO; insoluble in H2O; ≥2.682 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- 4.52±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 81035
- Product name
- CDDO
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 81035
- Product name
- CDDO
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $270
- Updated
- 2024/03/01
- Product number
- 81035
- Product name
- CDDO
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- B118660
- Product name
- Bardoxolone
- Packaging
- 25mg
- Price
- $700
- Updated
- 2021/12/16
- Product number
- B118660
- Product name
- Bardoxolone
- Packaging
- 100mg
- Price
- $1355
- Updated
- 2021/12/16
Bardoxolone Chemical Properties,Usage,Production
Chemical Properties
Tan Solid
Uses
Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription fa ctor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.
Definition
ChEBI: Bardoxolone is a member of cyclohexenones.
Biological Activity
bardoxolone methyl, previously known as rta 402, is the lead molecule in reata's portfolio of antioxidant inflammation modulators (aims). the aims are potent inducers of the transcription factor nrf2, an important biological target that controls the production of many of the body's antioxidant and detoxification enzymes. because oxidative stress and inflammation occur throughout the course of chronic kidney disease (ckd) and are known to contribute to loss of kidney function, agents that activate the nrf2 pathway in patients with ckd may provide a novel method for preserving or improving kidney function. bardoxolone methyl is currently being investigated as a potential oral once-a-day treatment for ckd.
Bardoxolone Preparation Products And Raw materials
Raw materials
Preparation Products
Bardoxolone Suppliers
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