(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid
- Product Name
- (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid
- CAS No.
- 943134-39-2
- Chemical Name
- (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid
- Synonyms
- ZP1609;ZP-1609;GAP-134;ZP 1609;Danegaptide;danegaptide,ZP1609;Danegaptide free base;GAP-134 (Danegaptide);L-Proline, glycyl-4-(benzoylamino)-, (4R)-;DANEGAPTIDE;ZP1609;GAP134;GAP 134;ZP-1609;ZP 1609
- CBNumber
- CB72485004
- Molecular Formula
- C14H17N3O4
- Formula Weight
- 291.3
- MOL File
- 943134-39-2.mol
(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid Property
- Boiling point:
- 642.4±55.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO
- form
- Powder
- pka
- 2.93±0.40(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FA151343
- Product name
- (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylicacid
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FA151343
- Product name
- (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylicacid
- Packaging
- 5mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 2862AH
- Product name
- (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylicacid
- Packaging
- 2mg
- Price
- $129
- Updated
- 2021/12/16
- Product number
- FA151343
- Product name
- (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylicacid
- Packaging
- 10mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- 2862AH
- Product name
- (2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylicacid
- Packaging
- 5mg
- Price
- $207
- Updated
- 2021/12/16
(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid Chemical Properties,Usage,Production
Uses
Danegaptide (GAP-134) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].
Definition
ChEBI: Danegaptide is a dipeptide.
in vivo
Danegaptide (GAP-134, compound 9f) is evaluated for in vivo efficacy in the mouse CaCl2 model after oral administration. For doses of 5-20 mg/kg po, Danegaptide significantly prolongs the time to conduction block in mice after the infusion of CaCl2[1].
Danegaptide (GAP-134) is biologically active upon oral administration at an average plasma concentration of 250 nM, and reduces atrial fibrillation in a dog model. Danegaptide has no effect on heart rate, arterial blood pressure or other electrocardiogram (ECG) parameters. Danegaptide is an effective antiarrhythmic compound in the setting of ischaemia/reperfusion-induced arrhythmogenesis in barbiturate-anesthetized, open-chest beagles[2].
References
[1] John A Butera, et al. Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. J Med Chem. 2009 Feb 26;52(4): DOI:10.1021/jm801558d
[2] Elke De Vuyst, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. DOI:10.1111/j.1476-5381.2011.01244.x
(2S,4R)-1-(2-Aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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