Difluoromethyl phenyl sulfone
- Product Name
- Difluoromethyl phenyl sulfone
- CAS No.
- 1535-65-5
- Chemical Name
- Difluoromethyl phenyl sulfone
- Synonyms
- PhSO2CF2H;[(Difluoromethyl)sulfonyl]benzene;Difluoromethyl phenyl sul;Phenyl difluoromethyl sulfone;Difluoromethyl phenyl sulfone;Difluoromethylphenylsulfone,95%;1-(difluoroMethylsulfonyl)benzene;Difluoromethyl Phenyl Sulfone >Difluoromethyl phenyl sulfone >=97%;Benzene, [(difluoroMethyl)sulfonyl]-
- CBNumber
- CB72485024
- Molecular Formula
- C7H6F2O2S
- Formula Weight
- 192.18
- MOL File
- 1535-65-5.mol
Difluoromethyl phenyl sulfone Property
- Melting point:
- 24-25℃
- Boiling point:
- 115-120 °C(Press: 7 Torr)
- Density
- 1.348
- refractive index
- 1.5000
- Flash point:
- 128℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- liquid
- color
- colorless
- Water Solubility
- Soluble in chloroform and water.
- BRN
- 2259218
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 742600
- Product name
- Difluoromethyl phenyl sulfone
- Purity
- ≥97%
- Packaging
- 1g
- Price
- $82.3
- Updated
- 2024/03/01
- Product number
- 742600
- Product name
- Difluoromethyl phenyl sulfone
- Purity
- ≥97%
- Packaging
- 10g
- Price
- $478
- Updated
- 2024/03/01
- Product number
- D4764
- Product name
- Difluoromethyl Phenyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $71
- Updated
- 2024/03/01
- Product number
- D4764
- Product name
- Difluoromethyl Phenyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $248
- Updated
- 2024/03/01
- Product number
- H64760
- Product name
- Difluoromethyl phenyl sulfone, 95%
- Packaging
- 1g
- Price
- $65.65
- Updated
- 2024/03/01
Difluoromethyl phenyl sulfone Chemical Properties,Usage,Production
Description
Difluoromethyl phenyl sulfone is a powerful nucleophilic difluoromethylation reagent due to the high reactivity of the sulfonyl-stabilized difluoromethyl anion towards many electrophiles including carbonyls, imines, alkyl halides, and cyclic sulfates and sulfamidates. In the nucleophilic reaction step, depending on the substrate structure, strong bases are used to generate the nucleophilic (phenylsulfonyl)difluoromethyl anion in situ. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the (phenylsulfonyl)difluoromethylated compounds can undergo β-elimination to afford gem-difluoroalkenes.
Chemical Properties
light yellow liquid
Uses
Efficient reagent for difluoromethylation of carbonyls and aldehydes.
Uses
Difluoromethyl Phenyl Sulfone has been used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls
Reactions
(1) Difluoromethylation of alkyl halides.
(2) Difluoromethylation of aldehydes and ketones.
(3) Difluoromethylenation of aldimines and ketimines.
(4) Difluoromethylation of cyclic sulfates and sulfamidates.
(5) (Phenylsulfonyl)difluoromethylation of carboxylic acid esters.
(6) Difluoromethylenation of alkyl halides.
(7) Difluoromethylenation of aromatic aldehydes.
References
[1] G. PRAKASH. Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion equivalent.[J]. Organic Letters, 2004. DOI:10.1002/CHIN.200509059.
[2] G. K. SURYA PRAKASH. Difluoromethyl Phenyl Sulfone, a Difluoromethylidene Equivalent: Use in the Synthesis of 1,1-Difluoro-1-alkenes.[J]. ChemInform, 2005. DOI:10.1002/chin.200504098.
[3] G. K. SURYA PRAKASH. Nucleophilic Difluoromethylation of Primary Alkyl Halides Using Difluoromethyl Phenyl Sulfone as a Difluoromethyl Anion Equivalent[J]. Organic Letters, 2004, 6 23: 4315-4317. DOI:10.1021/ol048166i.
Difluoromethyl phenyl sulfone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Difluoromethyl phenyl sulfone manufacturers
- Product
- Difluoromethyl phenyl sulfone 1535-65-5
- Price
- US $0.10/kg
- Min. Order
- 0.005kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-15
- Product
- [(Difluoromethyl)sulfonyl]benzene 1535-65-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24