5-Nitro-1H-pyrazolo[3,4-b]pyridine
- Product Name
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine
- CAS No.
- 63572-73-6
- Chemical Name
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine
- Synonyms
- 5-Nitro-1H-pyrazolo[3,4-b...;5-Nitro-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridine,5-nitro-
- CBNumber
- CB72485554
- Molecular Formula
- C6H4N4O2
- Formula Weight
- 164.12
- MOL File
- 63572-73-6.mol
5-Nitro-1H-pyrazolo[3,4-b]pyridine Property
- Melting point:
- 212-213℃
- Boiling point:
- 233.4±50.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.83±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H4N4O2/c11-10(12)5-1-4-2-8-9-6(4)7-3-5/h1-3H,(H,7,8,9)
- InChIKey
- RXLQRSOJODHPES-UHFFFAOYSA-N
- SMILES
- C12NN=CC1=CC([N+]([O-])=O)=CN=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N497145
- Product name
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0043846
- Product name
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- CS-0043846
- Product name
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- W7549
- Product name
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 1g
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CS-0043846
- Product name
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $335
- Updated
- 2021/12/16
5-Nitro-1H-pyrazolo[3,4-b]pyridine Chemical Properties,Usage,Production
Synthesis
34461-00-2
1225387-53-0
63572-73-6
The general procedure for the synthesis of 5-nitro-7-azaindazole from the sodium salt of nitromalonaldehyde and 3H-pyrazol-3-amine was as follows: 3H-pyrazol-3-amine (0.804 g, 9.48 mmol) and nitromalonaldehyde monohydrate (1.56 g, 9.96 mmol) were suspended in acetic acid (12 mL), and the mixture was heated to 90 °C and stirred overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into water (50 mL). The resulting solid product was collected by filtration and the solid was washed with distilled water (3 x 20 mL). Finally, the solid was dried under vacuum to afford 5-nitro-1H-pyrazolo[3,4-b]pyridine (1.40 g, 84% yield) as a solid product.
References
[1] Patent: WO2011/25968, 2011, A1. Location in patent: Page/Page column 49
[2] Patent: WO2009/111279, 2009, A1. Location in patent: Page/Page column 96
[3] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1992, vol. 28, # 11, p. 1335 - 1339
[4] Khimiya Geterotsiklicheskikh Soedinenii, 1992, # 11, p. 1560 - 1564
[5] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 5, p. 342 - 347
5-Nitro-1H-pyrazolo[3,4-b]pyridine Preparation Products And Raw materials
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View Lastest Price from 5-Nitro-1H-pyrazolo[3,4-b]pyridine manufacturers
- Product
- 5-Nitro-1H-pyrazolo[3,4-b]pyridine 63572-73-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-25