2-CHLORO-3-QUINOLINECARBOXYLIC ACID
- Product Name
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
- CAS No.
- 73776-25-7
- Chemical Name
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
- Synonyms
- AKOS BBS-00007300;VITAS-BB TBB000076;RARECHEM AL BE 0745;IFLAB-BB F1973-0014;3-Carboxy-2-chloroquinoline;2-chloro-3-quinolinecarboxylate;2-chloroquinoline-3-carboxylate;2-CHLORO-3-QUINOLINECARBOXYLIC ACID;2-CHLORO-QUINOLINE-3-CARBOXYLIC ACID;2-Chloroquinoline-3-carboxylicacid95%
- CBNumber
- CB7248560
- Molecular Formula
- C10H6ClNO2
- Formula Weight
- 207.61
- MOL File
- 73776-25-7.mol
2-CHLORO-3-QUINOLINECARBOXYLIC ACID Property
- Melting point:
- 199-240 °C
- Boiling point:
- 363.8±27.0 °C(Predicted)
- Density
- 1.469±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- 2.06±0.30(Predicted)
- form
- solid
- color
- Grey
- InChI
- InChI=1S/C10H6ClNO2/c11-9-7(10(13)14)5-6-3-1-2-4-8(6)12-9/h1-5H,(H,13,14)
- InChIKey
- XFSORZYTTCOBFN-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2)C=C(C(O)=O)C=1Cl
- CAS DataBase Reference
- 73776-25-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2933491090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 688517
- Product name
- 2-Chloroquinoline-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $95
- Updated
- 2023/06/20
- Product number
- B419320
- Product name
- 2-Chloroquinoline-3-carboxylic acid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H21-5-W9
- Product name
- 2-Chloroquinoline-3-carboxylic acid
- Purity
- 95.0%
- Packaging
- 5G
- Price
- $557
- Updated
- 2021/12/16
- Product number
- HCH0019135
- Product name
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $765.23
- Updated
- 2021/12/16
- Product number
- HCH0019135
- Product name
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
2-CHLORO-3-QUINOLINECARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
Useful quinolinecarboxylic acid for quinoline chemistry.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 32, p. 2178, 1989 DOI: 10.1021/jm00129a026
Journal of Heterocyclic Chemistry, 26, p. 1589, 1989
Synthesis
73568-25-9
73776-25-7
General procedure for the synthesis of 2-chloro-3-quinolinecarboxylic acid from 2-chloro-3-quinolinecarboxaldehyde: General method: a mixed solution of 2-chloro-3-quinolinecarboxaldehyde (0.5 mmol), tert-butylhydrogen peroxide (TBHP, 4.0 eq.), and dichloroethane (DCE, 2.0 mL) was placed under aerobic environment and heated at 80°C for 6 to 8 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the reaction mixture and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and saturated saline and subsequently dried over anhydrous sodium sulfate (Na2SO4). The organic solvent was removed by concentration under reduced pressure, and the resulting crude product was purified by column chromatography (eluent ratio: hexane:ethyl acetate=15:5) to afford the target product 2-chloro-3-quinolinecarboxylic acid.
References
[1] Tetrahedron Letters, 2018, vol. 59, # 11, p. 1019 - 1022
[2] Green Chemistry, 2012, vol. 14, # 6, p. 1649 - 1656
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 24, p. 10329 - 10342
[4] Australian Journal of Chemistry, 2017, vol. 70, # 10, p. 1082 - 1092
[5] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 5, p. 1339 - 1340
2-CHLORO-3-QUINOLINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-3-QUINOLINECARBOXYLIC ACID manufacturers
- Product
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID 73776-25-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-27
- Product
- 2-CHLORO-3-QUINOLINECARBOXYLIC ACID 73776-25-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 90%-99.9%
- Supply Ability
- 1000kg
- Release date
- 2019-07-04