Methyl 1-methyl-indazole-5-carboxylate
- Product Name
- Methyl 1-methyl-indazole-5-carboxylate
- CAS No.
- 1092351-82-0
- Chemical Name
- Methyl 1-methyl-indazole-5-carboxylate
- Synonyms
- Methyl 1-methyl-indazole-5-carboxylate;1-METHYL-1H-INDAZOLE-5-CARBOXYLIC ACID M;Methyl 1-Methyl-1H-indazol-5-carboxylate;5-(Methoxycarbonyl)-1-methyl-1H-indazole;methyl 1-methyl-1H-indazole-5-carboxylate;1-Methyl-1H-indazol-5-carboxylic acid methyl ester;1-Methyl-1H-indazole-5-carboxylic acid methyl ester;1H-Indazole-5-carboxylic acid, 1-methyl-, methyl ester;1-METHYL-1H-INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER(WX618113)
- CBNumber
- CB72485600
- Molecular Formula
- C10H10N2O2
- Formula Weight
- 190.2
- MOL File
- 1092351-82-0.mol
Methyl 1-methyl-indazole-5-carboxylate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M338733
- Product name
- Methyl1-Methyl-1H-indazole-5-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H23-1-P1
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- OR30719
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $142
- Updated
- 2021/12/16
- Product number
- 187946
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $245
- Updated
- 2021/12/16
- Product number
- 4H23-1-P1
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
Methyl 1-methyl-indazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
473416-12-5
74-88-4
1092351-82-0
Methyl 1H-indazole-5-carboxylate (22 g, 0.13 mol) and iodomethane (62 g, 0.44 mol) were added to potassium carbonate (60 g, 0.44 mol) in N,N-dimethylformamide (200 mL). Subsequently, iodomethane was added dropwise at room temperature and the reaction mixture was stirred for 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (200 mL) and extracted with ethyl acetate (4 x 200 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. Purification by silica gel column chromatography using a petroleum ether solution containing 2% ethyl acetate as eluent gave methyl 1-methyl-1H-indazole-5-carboxylate as an orange solid (13 g, 55% yield). The product was analyzed by LC-MS (ES, m/z): [M + H]+ 191.0. 1H NMR (300 MHz, DMSO-d6) δ: 8.48 (s, 1H), 8.24 (s, 1H), 7.97-7.94 (dd, J = 1.50, 8.70 Hz, 1H), 7.77-7.72 (m, 1H), 4.09 (s. 3H), 3.88 (s, 3H).
References
[1] Journal of Organic Chemistry, 2014, vol. 79, # 16, p. 7286 - 7293
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[3] Patent: WO2009/144554, 2009, A1. Location in patent: Page/Page column 48
Methyl 1-methyl-indazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 1-methyl-indazole-5-carboxylate Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1370
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 3995
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- 010-60400365-8001 15910885229
- Fax
- 010-60400361
- service@bellenchem.com
- Country
- China
- ProdList
- 4514
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66096098 3165145969
- Fax
- QQ3165145969
- sales@accoronpharm.com
- Country
- China
- ProdList
- 3924
- Advantage
- 55
- Tel
- 18066080842 13952020641
- Fax
- 025-58912720
- bamd@foxmail.com
- Country
- China
- ProdList
- 759
- Advantage
- 55
- Tel
- 13062833949; 4006653949 4006653949
- Fax
- QQ: 2136646215
- fred.wen@crcorporation.cn
- Country
- China
- ProdList
- 9757
- Advantage
- 58
View Lastest Price from Methyl 1-methyl-indazole-5-carboxylate manufacturers
- Product
- Methyl 1-methyl-indazole-5-carboxylate 1092351-82-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09