Methyl 1-methyl-indazole-5-carboxylate
- Product Name
- Methyl 1-methyl-indazole-5-carboxylate
- CAS No.
- 1092351-82-0
- Chemical Name
- Methyl 1-methyl-indazole-5-carboxylate
- Synonyms
- Methyl 1-methyl-indazole-5-carboxylate;1-METHYL-1H-INDAZOLE-5-CARBOXYLIC ACID M;Methyl 1-Methyl-1H-indazol-5-carboxylate;5-(Methoxycarbonyl)-1-methyl-1H-indazole;methyl 1-methyl-1H-indazole-5-carboxylate;1-Methyl-1H-indazol-5-carboxylic acid methyl ester;1-Methyl-1H-indazole-5-carboxylic acid methyl ester;1H-Indazole-5-carboxylic acid, 1-methyl-, methyl ester;1-METHYL-1H-INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER(WX618113)
- CBNumber
- CB72485600
- Molecular Formula
- C10H10N2O2
- Formula Weight
- 190.2
- MOL File
- 1092351-82-0.mol
Methyl 1-methyl-indazole-5-carboxylate Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M338733
- Product name
- Methyl1-Methyl-1H-indazole-5-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H23-1-P1
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- OR30719
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $142
- Updated
- 2021/12/16
- Product number
- 187946
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $245
- Updated
- 2021/12/16
- Product number
- 4H23-1-P1
- Product name
- Methyl 1-methyl-1H-indazole-5-carboxylate
- Packaging
- 1g
- Price
- $168
- Updated
- 2021/12/16
Methyl 1-methyl-indazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
473416-12-5
74-88-4
1092351-82-0
Methyl 1H-indazole-5-carboxylate (22 g, 0.13 mol) and iodomethane (62 g, 0.44 mol) were added to potassium carbonate (60 g, 0.44 mol) in N,N-dimethylformamide (200 mL). Subsequently, iodomethane was added dropwise at room temperature and the reaction mixture was stirred for 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (200 mL) and extracted with ethyl acetate (4 x 200 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. Purification by silica gel column chromatography using a petroleum ether solution containing 2% ethyl acetate as eluent gave methyl 1-methyl-1H-indazole-5-carboxylate as an orange solid (13 g, 55% yield). The product was analyzed by LC-MS (ES, m/z): [M + H]+ 191.0. 1H NMR (300 MHz, DMSO-d6) δ: 8.48 (s, 1H), 8.24 (s, 1H), 7.97-7.94 (dd, J = 1.50, 8.70 Hz, 1H), 7.77-7.72 (m, 1H), 4.09 (s. 3H), 3.88 (s, 3H).
References
[1] Journal of Organic Chemistry, 2014, vol. 79, # 16, p. 7286 - 7293
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[3] Patent: WO2009/144554, 2009, A1. Location in patent: Page/Page column 48
Methyl 1-methyl-indazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 1-methyl-indazole-5-carboxylate Suppliers
- Tel
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- Fax
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
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View Lastest Price from Methyl 1-methyl-indazole-5-carboxylate manufacturers
- Product
- Methyl 1-methyl-indazole-5-carboxylate 1092351-82-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09