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Methyl 1-methyl-indazole-5-carboxylate

Product Name
Methyl 1-methyl-indazole-5-carboxylate
CAS No.
1092351-82-0
Chemical Name
Methyl 1-methyl-indazole-5-carboxylate
Synonyms
Methyl 1-methyl-indazole-5-carboxylate;1-METHYL-1H-INDAZOLE-5-CARBOXYLIC ACID M;Methyl 1-Methyl-1H-indazol-5-carboxylate;5-(Methoxycarbonyl)-1-methyl-1H-indazole;methyl 1-methyl-1H-indazole-5-carboxylate;1-Methyl-1H-indazol-5-carboxylic acid methyl ester;1-Methyl-1H-indazole-5-carboxylic acid methyl ester;1H-Indazole-5-carboxylic acid, 1-methyl-, methyl ester;1-METHYL-1H-INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER(WX618113)
CBNumber
CB72485600
Molecular Formula
C10H10N2O2
Formula Weight
190.2
MOL File
1092351-82-0.mol
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Methyl 1-methyl-indazole-5-carboxylate Property

storage temp. 
Sealed in dry,Room Temperature
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M338733
Product name
Methyl1-Methyl-1H-indazole-5-carboxylate
Packaging
50mg
Price
$45
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-P1
Product name
Methyl 1-methyl-1H-indazole-5-carboxylate
Packaging
250mg
Price
$95
Updated
2021/12/16
Apolloscientific
Product number
OR30719
Product name
Methyl 1-methyl-1H-indazole-5-carboxylate
Packaging
1g
Price
$142
Updated
2021/12/16
SynQuest Laboratories
Product number
4H23-1-P1
Product name
Methyl 1-methyl-1H-indazole-5-carboxylate
Packaging
1g
Price
$168
Updated
2021/12/16
Matrix Scientific
Product number
187946
Product name
Methyl 1-methyl-1H-indazole-5-carboxylate
Packaging
1g
Price
$245
Updated
2021/12/16
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Methyl 1-methyl-indazole-5-carboxylate Chemical Properties,Usage,Production

Synthesis

473416-12-5

74-88-4

1092351-82-0

Methyl 1H-indazole-5-carboxylate (22 g, 0.13 mol) and iodomethane (62 g, 0.44 mol) were added to potassium carbonate (60 g, 0.44 mol) in N,N-dimethylformamide (200 mL). Subsequently, iodomethane was added dropwise at room temperature and the reaction mixture was stirred for 5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (200 mL) and extracted with ethyl acetate (4 x 200 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. Purification by silica gel column chromatography using a petroleum ether solution containing 2% ethyl acetate as eluent gave methyl 1-methyl-1H-indazole-5-carboxylate as an orange solid (13 g, 55% yield). The product was analyzed by LC-MS (ES, m/z): [M + H]+ 191.0. 1H NMR (300 MHz, DMSO-d6) δ: 8.48 (s, 1H), 8.24 (s, 1H), 7.97-7.94 (dd, J = 1.50, 8.70 Hz, 1H), 7.77-7.72 (m, 1H), 4.09 (s. 3H), 3.88 (s, 3H).

References

[1] Journal of Organic Chemistry, 2014, vol. 79, # 16, p. 7286 - 7293
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[3] Patent: WO2009/144554, 2009, A1. Location in patent: Page/Page column 48

Methyl 1-methyl-indazole-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 1-methyl-indazole-5-carboxylate Suppliers

China 50 India 1 United Kingdom 1 United States 4 Global 56
Aladdin Scientific
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tp@aladdinsci.com
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United States
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52923
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Combi-Blocks Inc.
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sales@combi-blocks.com
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United States
ProdList
6618
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SynQuest Laboratories, Inc.
Tel
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Email
info@synquestlabs.com
Country
United States
ProdList
6871
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Frontier Scientific, Inc.
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Email
sales@frontiersci.com
Country
United States
ProdList
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View Lastest Price from Methyl 1-methyl-indazole-5-carboxylate manufacturers

Career Henan Chemical Co
Product
Methyl 1-methyl-indazole-5-carboxylate 1092351-82-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

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  • 1092351-82-0