Methyl 5-bromo-7-azaindole-3-carboxylate
- Product Name
- Methyl 5-bromo-7-azaindole-3-carboxylate
- CAS No.
- 872619-43-7
- Chemical Name
- Methyl 5-bromo-7-azaindole-3-carboxylate
- Synonyms
- Methyl 5-bromo-7-azaindole-3-carboxylate;Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylate;5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-, Methyl ester
- CBNumber
- CB72485620
- Molecular Formula
- C9H7BrN2O2
- Formula Weight
- 255.07
- MOL File
- 872619-43-7.mol
Methyl 5-bromo-7-azaindole-3-carboxylate Property
- Density
- 1.709±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.33±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M296570
- Product name
- Methyl5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-B0568
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxylicacid,5-bromo-,methylester
- Purity
- 96.95%
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- CS-B0568
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxylicacid,5-bromo-,methylester
- Purity
- 96.95%
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 3838AH
- Product name
- Methyl5-bromo-1H-pyrrolo[2,3-B]pyridine-3-carboxylate
- Packaging
- 100mg
- Price
- $163
- Updated
- 2021/12/16
- Product number
- CS-B0568
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxylicacid,5-bromo-,methylester
- Purity
- 96.95%
- Packaging
- 1g
- Price
- $172
- Updated
- 2021/12/16
Methyl 5-bromo-7-azaindole-3-carboxylate Chemical Properties,Usage,Production
Uses
Methyl 5-bromo-7-azaindole-3-carboxylate is an organic synthesis intermediate, mainly used in the synthesis of biologically active compounds as a key building block in the synthesis process.
Synthesis
67-56-1
849068-61-7
872619-43-7
5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (480 mg, 2 mmol, 1.0 eq.) was used as a starting material and mixed with concentrated hydrochloric acid. A methanol solution containing sulfuric acid (0.5 mL, catalytic amount) was added to the mixture and the reaction mixture was subsequently refluxed for 24 hours. Upon completion of the reaction, the solvent was removed by concentration via rotary evaporator. The obtained residue was dissolved in ethyl acetate and subsequently washed with saturated aqueous sodium bicarbonate solution. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (450 mg, 85% yield) as a white solid.LCMS analysis showed (M+H)+ m/z calculated value of 256.1 and measured value of 256.1.
References
[1] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00694
[2] Patent: WO2016/178110, 2016, A1. Location in patent: Page/Page column 150
[3] Patent: WO2006/1754, 2006, A1. Location in patent: Page/Page column 21-22
Methyl 5-bromo-7-azaindole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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